Differential expression of ARIA isoforms in the rat brain

AbstractARIA, heregulin, neu differentiation factor, and glial growth factor are members of a new family of growth and differentiation factors whose effects have been assayed on Schwann cells, skeletal muscle cells, and mammary tumor cell lines. To gain insight into their roles in the CNS, we studied the expression of ARIA in the rat brain. We found ARIA mRNA in all cholinergic neurons throughoutthe CNS, including motor neurons and cells of the medial septal nucleus and the nucleus basalis of Meynert. We also found that ARIA induces tyrosine phosphorylation of a 185 kDa protein in central and peripheral targets of these cholinergic neurons. ARIA mRNA, however, is not restricted to cholinergic neurons, suggesting that it may also play a role at other types of synapses. Its distribution in germinal layers of the telencephalon and cerebellum suggests that it may also play a role in the proliferation and/or migration of neuronal and glial precursor cells

Use of a Single Coil Transvenous Electrode with an Abdominally Placed Implantable Cardioverter Defibrillator in Children

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73702/1/j.1540-8159.2000.tb00859.x.pd

Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation

AbstractBoth theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output. We report here that inhibition of excitatory synaptic transmission in cultured spinal neurons leads to an increase in mEPSC amplitudes, accompanied by an equivalent increase in the accumulation of AMPA receptors at synapses. Conversely, increasing excitatory synaptic activity leads to a decrease in synaptic AMPA receptors and a decline in mEPSC amplitude. The time course of this synaptic remodeling is slow, similar to the metabolic half-life of neuronal AMPA receptors. Moreover, inhibiting excitatory synaptic transmission significantly prolongs the half-life of the AMPA receptor subunit GluR1, suggesting that synaptic activity modulates the size of the mEPSC by regulating the turnover of postsynaptic AMPA receptors

Implantable Cardioverter Defibrillator Therapy for Life-Threatening Arrhythmias in Young Patients

Objectives: This study examined the indications, efficacy and outcomes of implantable cardioverter defibrillator (ICD) use in the pediatric population.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46402/1/10840_2004_Article_5092105.pd

Effects of eight neuropsychiatric copy number variants on human brain structure

Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date neuroimaging studies have typically been carried out one mutation at a time, showing that CNVs have large effects on brain anatomy. Here, we aimed to characterize and quantify the distinct brain morphometry effects and latent dimensions across 8 neuropsychiatric CNVs. We analyzed T1-weighted MRI data from clinically and non-clinically ascertained CNV carriers (deletion/duplication) at the 1q21.1 (n = 39/28), 16p11.2 (n = 87/78), 22q11.2 (n = 75/30), and 15q11.2 (n = 72/76) loci as well as 1296 non-carriers (controls). Case-control contrasts of all examined genomic loci demonstrated effects on brain anatomy, with deletions and duplications showing mirror effects at the global and regional levels. Although CNVs mainly showed distinct brain patterns, principal component analysis (PCA) loaded subsets of CNVs on two latent brain dimensions, which explained 32 and 29% of the variance of the 8 Cohen’s d maps. The cingulate gyrus, insula, supplementary motor cortex, and cerebellum were identified by PCA and multi-view pattern learning as top regions contributing to latent dimension shared across subsets of CNVs. The large proportion of distinct CNV effects on brain morphology may explain the small neuroimaging effect sizes reported in polygenic psychiatric conditions. Nevertheless, latent gene brain morphology dimensions will help subgroup the rapidly expanding landscape of neuropsychiatric variants and dissect the heterogeneity of idiopathic conditions

Halloween mystery music!, October 31, 1974 : Gerald Fischbach, violinist

Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, October 31, 1974, program no. 37 of the Department of Music's 1974-1975 season.Gerald Fischbach, violin ; with various instrumentalists.Reel 1: Introduction by Gerald Fischbach -- (9:32) Halloween, from Three outdoor scenes: for piano quintet and maybe drum / Charles Ives -- (19:16) Piano trio in D, op. 70, no. 1 ""Ghost"". Duo for violin and cello. Allegro vivace e con brio ; (23:59) Largo assai ed espressivo ; (31:02) Presto / Ludwig van Beethoven.Reel 2: Duo for violin and cello. Preludium ; (4:55) Rondo / Bohuslav Martinu -- (16:45) ""Devil's trill"" sonata / Giuseppe Tartini -- (31:12) Gerald Fischbach comments -- (31:45) Baal Shem. Nigun / Ernest Bloch

Faculty recital, February 24, 1979 : Gerald Fischbach, violinist; Terry Turner-Jones, pianist.

Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, October 24, 1979, program no. 166 of the Department of Music's 1978-1979 season.Gerald Fischbach, violin ; Terry Turner-Jones, piano ; Western Chamber Strings (2nd work).Information from performance program.Reel 1: Sonata no. 2. Autumn ; In the barn ; The revival / Charles Ives -- Rondo in A major for violin and strings, D. 438 / Franz SchubertReel 2: Sonata in G major, K. 379 / Wolfgang Amadeus Mozart -- Sonata in A major, op. 13 / Gabriel Fauré