Old Slow Town : Detroit During the Civil War

Dissent, Opportunity, and Transformation in Civil War Detroit Over the past quarter-century, Civil War historians have turned away from simply focusing on the fighting on the battlefield and politics and strategy in Washington, Richmond, and various state capitals, giving substantial atten...

Ohio History Spring 2016

https://kent-islandora.s3.us-east-2.amazonaws.com/node/10126/OH-v123n1-thumb.jpgOHIO HISTORY Contents for Volume 123, Number 1, Spring 2016 Contributors ...... 4 Editor’s Note ...... 5 &nbsp; Love and Danger on the Underground Railroad: George and Edy Duncan’s Journey to Freedom, 1820 Roy E. Finkenbine&nbsp;...... 7 From Places Between to Industrialized Countryside: Creating Enriched Uranium and Coal-Fired Energy in the Ohio Valley in the Early Cold War Era, 1952–65 Megan Chew ...... 26 President William T. Jerome III: Why Bowling Green State University Remained Open after the Kent State Shootings Joshua Casmir Catalano ...... 51 The Wright Brothers’ Early Photography: A Research Note Casey Huegel ...... 73 Exhibit Review: The John P. Parker House, Ripley, Ohio ...... 88 &nbsp; Book Reviews ...... 91 On the cover: Daniel Henderson, a young neighbor of the Wright brothers, poses with arms crossed outside the Wright family home at 7 Hawthorn Street, Dayton, 1899‒1901. (Source: Library of Congress, Prints and Photographs Division, LC-W85-28)</p

Low-molecular-weight heparin in the treatment of patients with venous thromboembolism

Background Low-molecular-weight heparin is known to be safe and effective for the initial Treatment of patients with proximal deep-vein thrombosis. However, its application to patients with pulmonary embolism or previous episodes of thromboembolism has not been studied. Methods We randomly assigned 1021 patients with symptomatic venous thromboembolism to fixed-dose, subcutaneous low-molecular-weight heparin (reviparin sodium) or adjusted-dose, intravenous unfractionated heparin. Oral anticoagulant therapy with a coumarin derivative was started concomitantly and continued for 12 weeks, Approximately one third of the patients had associated pulmonary embolism, The outcome events studied over the 12 weeks were symptomatic recurrent venous thromboembolism, major bleeding, and death. We sought to determine whether low-molecular-weight heparin is at least equivalent to unfractionated heparin in patients with venous thromboembolism. Results Twenty-seven of the 510 patients assigned to low-molecular-weight heparin (5.3 percent) had recurrent thromboembolic events, as compared with 25 of the 511 patients assigned to unfractionated heparin (4.9 percent). The difference of 0.4 percentage point indicates that the two therapies have equivalent value according to our predetermined definition of equivalence. Sixteen patients assigned to low-molecular-weight heparin (3.1 percent) and 12 patients assigned to unfractionated heparin (2.3 percent) had episodes of major bleeding (P=0.63), and the mortality rates in the two groups were 7.1 percent and 7.6 percent, respectively (P=0.89). Conclusions Fixed-dose, subcutaneous low-molecular-weight heparin is as effective and safe as adjusted-dose, intravenous unfractionated heparin for the initial management of venous thromboembolism, regardless of whether the patient has pulmonary embolism or a history of venous thromboembolism. (C) 1997, Massachusetts Medical Society