Deep K_s-near-infrared Surface Photometry of 80 Dwarf Irregular Galaxies in the Local Volume

We present deep near-infrared (K_s) images and surface photometry for 80 dwarf irregular galaxies (dIs) within ~5 Mpc of the Milky Way. The galaxy images were obtained at five different facilities between 2004 and 2006. The image reductions and surface photometry have been performed using methods specifically designed for isolating faint galaxies from the high and varying near-infrared sky level. Fifty-four of the 80 dIs have surface brightness profiles which could be fit to a hyperbolic-secant (sech) function, while the remaining profiles could be fit to the sum of a sech and a Gaussian function. From these fits, we have measured central surface brightnesses, scale lengths, and integrated magnitudes. This survey is part of a larger study of the connection between large-scale structure and the global properties of dIs, the hypothesized building-blocks of more massive galaxies

Cost-effectiveness of alternative methods of surgical repair of inguinal hernia

Objectives: To assess the relative cost-effectiveness of laparoscopic methods of inguinal hernia repair compared with open flat mesh and open non-mesh repair. Methods: Data on the effectiveness of these alternatives came from three systematic reviews comparing: (i) laparoscopic methods with open flat mesh or non-mesh methods; (ii) open flat mesh with open non-mesh repair; and (iii) methods that used synthetic mesh to repair the hernia defect with those that did not. Data on costs were obtained from the authors of economic evaluations previously conducted alongside trials included in the reviews. A Markov model was used to model cost-effectiveness for a five-year period after the initial operation. The outcomes of the model were presented using a balance sheet approach and as cost per hernia recurrence avoided and cost per extra day at usual activities. Results: Open flat mesh was the most cost-effective method of preventing recurrences. Laparoscopic repair provided a shorter period of convalescence and less long-term pain compared with open flat mesh but was more costly. The mean incremental cost per additional day back at usual activities compared with open flat mesh was €38 and €80 for totally extraperitoneal and transabdominal preperitoneal repair, respectively. Conclusions: Laparoscopic repair is not cost-effective compared with open flat mesh repair in terms of cost per recurrence avoided. Decisions about the use of laparoscopic repair depend on whether the benefits (reduced pain and earlier return to usual activities) outweigh the extra costs and intraoperative risks. On the evidence presented here, these extra costs are unlikely to be offset by the short-term benefits of laparoscopic repair.Luke Vale, Adrian Grant, Kirsty McCormack, Neil W. Scott and the EU Hernia Trialists Collaboratio

Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo

The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the treatment of monogenetic diseases. Symptomatic treatment is now replaced by a causal pharmacological therapy correcting misfolding of the defective phenylalanine hydroxylase (PAH) in numerous patients. Here, we disclose BH4 responsiveness in Pahenu1, a mouse model for PAH deficiency. Loss of function resulted from loss of PAH, a consequence of misfolding, aggregation, and accelerated degradation of the enzyme. BH4 attenuated this triad by conformational stabilization augmenting the effective PAH concentration. This led to the rescue of the biochemical phenotype and enzyme function in vivo. Combined in vitro and in vivo analyses revealed a selective pharmaceutical action of BH4 confined to the pathological metabolic state. Our data provide new molecular-level insights into the mechanisms underlying protein misfolding with loss of function and support a general model of pharmacological chaperone-induced stabilization of protein conformation to correct this intracellular phenotype. Pahenu1 will be essential for pharmaceutical drug optimization and to design individually tailored therapie

The Extinction and Distance of Maffei 1

We have obtained low- and high-resolution spectra of the core of the highly-reddened elliptical galaxy Maffei 1. From these data, we have obtained the first measurement of the Mg2 index, and have measured the velocity dispersion and radial velocity with improved accuracy. To evaluate the extinction, a correlation between the Mg2 index and effective V-I colour has been established for elliptical galaxies. Using a new method for correcting for effective wavelength shifts, we find A_V = 4.67 +/- 0.19 mag, which is lower by 0.4 mag than previously thought. To establish the distance, the Fundamental Plane for elliptical galaxies has been constructed in I. The velocity dispersion of Maffei 1, measured to be 186.8 +/- 7.4 km/s, in combination with modern wide-field photometry in I, leads to a distance of 2.92 +/- 0.37 Mpc. The Dn-sigma relation, which is independently calibrated, gives 3.08 +/- 0.85 Mpc and 3.23 +/- 0.67 Mpc from photometry in B and K`, respectively. The weighted mean of the three estimates is 3.01 +/- 0.30 Mpc. The distance and luminosity make Maffei 1 the nearest giant elliptical galaxy. The radial velocity of Maffei 1 is +66.4 +/- 5.0 km/s, significantly higher than the accepted value of -10 km/s. The Hubble distance corresponding to the mean velocity of Maffei 1, Maffei 2 and IC342 is 3.5 Mpc. Thus, it is unlikely that Maffei 1 has had any influence on Local Group dynamics