1,106 research outputs found
Force-Velocity Relations of a Two-State Crossbridge Model for Molecular Motors
We discuss the force-velocity relations obtained in a two-state crossbridge
model for molecular motors. They can be calculated analytically in two limiting
cases: for a large number and for one pair of motors. The effect of the
strain-dependent detachment rate on the motor characteristics is studied. It
can lead to linear, myosin-like, kinesin-like and anomalous curves. In
particular, we specify the conditions under which oscillatory behavior may be
found.Comment: 5 pages, 4 figures, REVTeX; thoroughly revised version; also
available at http://www.physik.tu-muenchen.de/~frey
Fluctuating-friction molecular motors
We show that the correlated stochastic fluctuation of the friction
coefficient can give rise to long-range directional motion of a particle
undergoing Brownian random walk in a constant periodic energy potential
landscape. The occurrence of this motion requires the presence of two
additional independent bodies interacting with the particle via friction and
via the energy potential, respectively, which can move relative to each other.
Such three-body system generalizes the classical Brownian ratchet mechanism,
which requires only two interacting bodies. In particular, we describe a simple
two-level model of fluctuating-friction molecular motor that can be solved
analytically. In our previous work [M.K., L.M and D.P. 2000 J. Nonlinear Opt.
Phys. Mater. vol. 9, 157] this model has been first applied to understanding
the fundamental mechanism of the photoinduced reorientation of dye-doped liquid
crystals. Applications of the same idea to other fields such as molecular
biology and nanotechnology can however be envisioned. As an example, in this
paper we work out a model of the actomyosin system based on the
fluctuating-friction mechanism.Comment: to be published in J. Physics Condensed Matter
(http://www.iop.org/Journals/JPhysCM
Forty years studying British politics : the decline of Anglo-America
The still present belief some 40 years ago that British politics was both exceptional and superior has been replaced by more theoretically sophisticated analyses based on a wider and more rigorously deployed range of research techniques, although historical analysis appropriately remains important. The American influence on the study of British politics has declined, but the European Union dimension has not been fully integrated. The study of interest groups has been in some respects a fading paradigm, but important questions related to democratic health have still to be addressed. Public administration has been supplanted by public policy, but economic policy remains under-studied. A key challenge for the future is the study of the management of expectations
Engaging patients, clinicians and health funders in weight management: the Counterweight Programme.
Background. The Counterweight Programme provides an evidence based and effective approach for weight management in routine primary care. Uptake of the programme has been variable for practices and patients. Aim. To explore key barriers and facilitators of practice and patient engagement in the Counterweight Programme and to describe key strategies used to address barriers in the wider implementation of this weight management programme in UK primary care. Methods. All seven weight management advisers participated in a focus group. In-depth interviews were conducted with purposeful samples of GPs (n = 7) and practice nurses (n = 15) from 11 practices out of the 65 participating in the programme. A total of 37 patients participated through a mixture of in-depth interviews (n = 18) and three focus groups. Interviews and focus groups were analysed for key themes that emerged. Results. Engagement of practice staff was influenced by clinicians beliefs and attitudes, factors relating to the way the programme was initiated and implemented, the programme content and organizational/contextual factors. Patient engagement was influenced by practice endorsement of the programme, clear understanding of programme goals, structured proactive follow-up and perception of positive outcomes. Conclusions. Having a clear understanding of programme goals and expectations, enhancing self-efficacy in weight management and providing proactive follow-up is important for engaging both practices and patients. The widespread integration of weight management programmes into routine primary care is likely to require supportive public policy
Congenital anomalies in low- and middle-income countries: the unborn child of global surgery.
Surgically correctable congenital anomalies cause a substantial burden of global morbidity and mortality. These anomalies disproportionately affect children in low- and middle-income countries (LMICs) due to sociocultural, economic, and structural factors that limit the accessibility and quality of pediatric surgery. While data from LMICs are sparse, available evidence suggests that the true human and financial cost of congenital anomalies is grossly underestimated and that pediatric surgery is a cost-effective intervention with the potential to avert significant premature mortality and lifelong disability
Microblogging, constituency service and impression management â UK MPs and the use of Twitter
Twitter, a microblogging site which allows users to deliver statements, thoughts and links in 140 characters to followers as well as a wider Internet audience, is the latest online communications technology adopted by MPs. Assessing the use of early adopters, this article considers which MPs are most likely to use Twitter (e.g. tweeting), and how. Content analysis of tweeting MPs was conducted, and identified personal and political characteristics which may influence use. The data suggested that of the six characteristics tested, gender, party and seniority had most impact on adoption. Applying Jones and Pittmanâs (1982) typology there is clear evidence that MPs use Twitter as a tool of impression management. Constituency service is a secondary function of the use of Twitter by MPs. Where MPs use Twitter as part of their constituency role it is to promote their local activity. We note that a small group of MPs use Twitter as a regular communication channel, but most are only occasionally dipping their toe into the microbloggersphere
Force and Motion Generation of Molecular Motors: A Generic Description
We review the properties of biological motor proteins which move along linear
filaments that are polar and periodic. The physics of the operation of such
motors can be described by simple stochastic models which are coupled to a
chemical reaction. We analyze the essential features of force and motion
generation and discuss the general properties of single motors in the framework
of two-state models. Systems which contain large numbers of motors such as
muscles and flagella motivate the study of many interacting motors within the
framework of simple models. In this case, collective effects can lead to new
types of behaviors such as dynamic instabilities of the steady states and
oscillatory motion.Comment: 29 pages, 9 figure
'This is what democracy looks like' : New Labour's blind spot and peripheral vision
New Labour in government since 1997 has been roundly criticized for not possessing a clear, coherent and consistent democratic vision. The absence of such a grand vision has resulted, from this critical perspective, in an absence of 'joined-up' thinking about democracy in an evolving multi-level state. Tensions have been all too apparent between the government's desire to exert central direction - manifested in its most pathological form as 'control freakery' - and its democratising initiatives derived from 'third-way' obsessions with 'decentralising', 'empowering' and 'enabling'. The purpose of this article is to examine why New Labour displayed such apparently impaired democratic vision and why it appeared incapable of conceiving of democratic reform 'in the round'. This article seeks to explain these apparent paradoxes, however, through utilising the notion of 'macular degeneration'. In this analysis, the perceived democratic blind spot of New Labour at Westminster is connected to a democratic peripheral vision, which has envisaged innovative participatory and decentred initiatives in governance beyond Westminster
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