Threading salen-type Cu- and Ni-complexes into one-dimensional coordination polymers: solution versus solid state and the size effect of the alkali metal ion

Compartmentalization of metal ions is crucial in biology as well as in materials science. For the synthesis of single source precursors, the preorganization of different metal ions is of particular interest for the low-temperature generation of mixed metal oxides. On the basis of a potentially Ω-shaped salen-type ligand providing an N2O2 as well as an O2O2 coordination site, mixed metal coordination compounds with Cu(II) or Ni(II) and alkali metal ions have been studied for their structural and optical properties. UV–vis and 1H NMR titrations show that the obtained compounds adopt partially different structures in solution compared to the solid state. In the latter case, the coordination geometry is mainly governed by the size of the alkali metal ion as well as the transition metal ion used

Compartmentalization of alkaline-earth metals in salen-type Cu- and Ni-complexes in solution and in the solid state

The precise arrangement of metal ions in type and number by a ligand represents an important challenge in biology as well as in materials science. The preorganization of different metal ions such as alkaline-earth and transition-metal ions is of particular interest for the design of catalysts or precursors of oxides. This study is based on a Ω- shaped salen-derived ligand comprising N2O2 and O2O2 coordination sites. The selective binding of Cu(II) and Ni(II) and alkaline-earth-metal ions is influenced by many factors such as the size of the cation, the solvent, or the counterion. UV–vis and 1H NMR titrations and single-crystal X-ray structures reveal that the obtained complexes tend to adopt different structures in solution compared to the solid state. Mainly discrete motifs with a stoichiometry 1:1 (LM1 to alkaline-earth-metal ions) have been shown to form in the solid state, whereas in solution, the 2:1 complexes are predominant

Sequential multiple-target sensor: In3+, Fe2+, and Fe3+ discrimination by an anthracene-based probe

Indium is a nonphysiological toxic metal widely used in industry. While misunderstood, its toxicity is proposed to be linked to a perturbation of Fe3+ homeostasis through the binding of In3+ ions to essential iron metalloproteins such as transferrins. Therefore, the monitoring of In3+ and Fe3+ in biological environments is of prime interest for both basic research and diagnosis. Here we report the design of a salen-type anthracene- based probe able to selectively sense and discriminate In3+ and Fe2+/3+ ions by fluoro-colorimetry

Bimetallic salen-based compounds and their potential applications

The new bimetallic coordination compounds [LNiAg(NO3)], [LCuMn(NO3)2], [LCuCu(NO3)2], [LCuZn(NO3)2], and [{LCuBi(NO3)3}(ACN)] have been synthesized from a salen-type ligand L containing two distinct coordination sites to accommodate (different) metal ions M1 and M2. In the solid state, the formation of 1:1 compounds (LCu:M2) is always observed, but interactions between the compounds lead to differences in packing. For example, a head-to-tail arrangement along the crystallographic b-axis is observed in the case of the LCuBi compound, and the LNiAg compound is polymeric, while its Cu homologue LCuAg forms a discrete dimer. Given the inherent potential of the preorganizing, two metal ions using L could be used to synthesize nanoscale copper–bismuth and −manganese mixed metal oxides as a function of the temperature. The combination of different bioactive metal ions within one ligand system was furthermore explored for antimicrobial efficiency

Threading Salen-type Cu- and Ni-Complexes into One-Dimensional Coordination Polymers: Solution versus Solid State and the Size Effect of the Alkali Metal Ion

Compartmentalization of metal ions is crucial in biology as well as in materials science. For the synthesis of single source precursors, the preorganization of different metal ions is of particular interest for the low-temperature generation of mixed metal oxides. On the basis of a potentially Ω-shaped salen-type ligand providing an N₂O₂ as well as an O₂O₂ coordination site, mixed metal coordination compounds with Cu­(II) or Ni­(II) and alkali metal ions have been studied for their structural and optical properties. UV–vis and ¹H NMR titrations show that the obtained compounds adopt partially different structures in solution compared to the solid state. In the latter case, the coordination geometry is mainly governed by the size of the alkali metal ion as well as the transition metal ion used

Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults

BACKGROUND: Respiratory syncytial virus (RSV) causes severe respiratory illnesses in infants and older adults. Older adults are frequently hospitalized with RSV illness and may experience loss of function. This study evaluated longitudinal changes in function associated with RSV hospitalization in older adults. METHODS: Adults ≥ 60 years hospitalized with laboratory-confirmed RSV were enrolled (N = 302). Demographics and comorbidities were collected. Functional status was assessed 2 weeks pre-hospitalization by recall, at enrollment, hospital discharge and 2, 4, and 6 months post-discharge using the Lawton-Brody Instrumental Activities of Daily Living (IADL) (scale 0-8) and Barthel ADL Index (scale 0-100). RESULTS: RSV-associated hospitalization resulted in acute functional loss. Median IADL (5 vs. 3, p \u3c 0.0001) and ADL (90 vs. 70, p \u3c 0.0001) scores decreased significantly from pre-hospitalization to admission and remained decreased at discharge. There were no statistically significant differences between pre-hospitalization and 2-, 4-, or 6-month scores. However, 33% and 32% of subjects experienced decreased 6-month IADL and ADL scores, respectively. Additionally, 14% required a higher level of care at discharge. When stratified by pre-hospitalization living situation, 6-month IADL scores declined significantly for those admitted from a skilled nursing facility (3 vs. 1, p = 0.001). In multivariate analysis, male sex and diabetes were associated with a 6-month decline in ADL score of ≥ 10. CONCLUSIONS: Older adults hospitalized with RSV demonstrate acute functional decline that may become prolonged. Pre-hospitalization living situation may predict patient outcomes. Further study is needed with hospitalized age-matched controls and refined measurement tools to better define the specific impact of RSV on function

Clinical impact of healthcare-associated respiratory syncytial virus in hospitalized adults

Objective: To describe the clinical impact of healthcare-associated (HA) respiratory syncytial virus (RSV) in hospitalized adults. Design: Retrospective cohort study within a prospective, population-based, surveillance study of RSV-infected hospitalized adults during 3 respiratory seasons: October 2017-April 2018, October 2018-April 2019, and October 2019-March 2020. Setting: The study was conducted in 2 academically affiliated medical centers. Patients: Each HA-RSV patient (in whom RSV was detected by PCR test ≥ 4 days after hospital admission) was matched (age, sex, season) with 2 community-onset (CO) RSV patients (in whom RSV was detected ≤ 3 days of admission). Methods: Risk factors and outcomes were compared among HA-RSV versus CO-RSV patients using conditional logistic regression. Escalation of respiratory support associated with RSV detection (day 0) from day - 2 to day + 4 was explored among HA-RSV patients. Results: In total, 84 HA-RSV patients were matched to 160 CO-RSV patients. In HA-RSV patients, chronic kidney disease was more common, while chronic respiratory conditions and obesity were less common. HA-RSV patients were not more likely to be admitted to an ICU or require mechanical ventilation, but they more often required a higher level of care at discharge compared with CO-RSV patients (44% vs 14%, respectively). Also, 29% of evaluable HA-RSV patients required respiratory support escalation; these patients were older and more likely to have respiratory comorbidities, to have been admitted to intensive care, and to die during hospitalization. Conclusions: HA-RSV in adults may be associated with escalation in respiratory support and an increased level of support in living situation at discharge. Infection prevention and control strategies and RSV vaccination of high-risk adults could mitigate the risk of HA-RSV

Ligand aspect ratio as a decisive factor for the self-assembly of coordination cages

It is possible to control the geometry and the composition of metallasupramolecular assemblies via the aspect ratio of their ligands. This point is demonstrated for a series of iron- and palladium-based coordination cages. Functionalized clathrochelate complexes with variable aspect ratios were used as rod-like metalloligands. A cubic FeII8L12 cage was obtained from a metalloligand with an intermediate aspect ratio. By increasing the length or by decreasing the width of the ligand, the self-assembly process resulted in the clean formation of tetrahedral FeII4L6 cages instead of cubic cages. In a related fashion, it was possible to control the geometry of PdII-based coordination cages. A metalloligand with a large aspect ratio gave an entropically favored tetrahedral PdII4L8 assembly, whereas an octahedral PdII6L12 cage was formed with a ligand of the same length but with an increased width. The aspect ratio can also be used to control the composition of dynamic mixtures of PdII cages. Out of two metalloligands with only marginally different aspect ratios, one gave rise to a self-sorted collection of PdII4L8 and PdII6L12 cages, whereas the other did not