Türkiye’de ulusal akne haftasında yapılan bilgilendirme seminerlerinin katılımcıların akne hakkındaki bilgi düzeylerine etkisi

Background and Design: To investigate the contribution of informative presentations about acne vulgaris and questionnaires administered before and after informative meetings on patients' awareness and consciousness. Materials and Methods: Participants were asked to fill out a 20-question survey before and after informative seminars in hospitals and secondary and high schools as part of National Acne Week. The level of statistical significance was set as p <= 0.05. Results: A total of 466 participants completed the survey before and after the seminar, and the mean age of the participants was 17.4 +/- 6.9. Before the seminar, 31.1% of participants thought that acne is originated from the liver, whereas this figure decreased to 16.7% after the seminar. In all, 47.6% of participants consulted doctors and 23.9% consulted social media to seek information about acne; however, after receiving training, 77% preferred to consult a doctor. Of the participants, 51.1% were expecting to see the results of acne treatment in 1 or 2 weeks, whereas 83.3% stated that the effects would be seen in 2 or 3 months after the seminar. When the participants' educational background was grouped as "secondary-high school-other," a statistically significant difference was obtained (p<0.05). Conclusion: Our study features both patients' misconceptions and their incorrect attitudes about acne, and their level of knowledge improved significantly as a result of educational seminars. The relative benefit derived from educational seminars was positively related to the participants' highest level of education.Amaç: Akne vulgaris ile ilgili bilgilendirme toplantısı öncesi ve sonrasında uygulanan anket formları ile bilgilendirici sunumların akne hakkındaki farkındalık ve bilinç düzeylerine katkısını incelemek amaçlanmaktadır. Gereç ve Yöntem: Ulusal Akne Haftası kapsamında hastane, ortaokul ve lise dengi okullarda verilen bilinçlendirme eğitimi öncesi ve sonrasında katılımcılardan 20 soruluk bir anket doldurmaları istendi. İstatistiksel anlamlılık düzeyi p≤0,05 olarak kabul edildi. Bulgular: Eğitim öncesi ve sonrasında anket formunu dolduran 466 kişinin yaş ortalaması 17,4±6,9 idi. Eğitim öncesi katılımcıların %31,1’i aknenin karaciğer kaynaklı olduğunu düşünürken, eğitim sonrası bu oran %16,7’ye indi. Akne hakkında bilgi almak için eğitim öncesi katılımcıların %47,6’sı doktora, %23,9’u sosyal medyaya başvururken, eğitim sonrası %77’si doktora başvurmayı tercih edeceğini belirtti. Katılımcıların %51,1’i akne tedavisinin 1-2 hafta içerisinde etkisini göstereceğini beklerken, eğitim sonrası %83,3’ü 2-3 ay kullandıktan sonra yanıt alınabileceğini belirtti. Kişilerin öğrenim durumları, “ortaokul-lise-diğer” olarak gruplandırıldığında, eğitim sonrası gruplar arasında öğrenim durumlarına göre istatistiksel olarak anlamlı bir farklılık saptandı (p=0,005). Sonuç: Çalışmamız bireylerin hem akne hakkındaki yanlış bilgi ve tutumlarını ön plana çıkarmakta, hem de hekimlerin vereceği eğitim seminerleri ve bilgilendirme toplantıları ile bilgi düzeylerinde kayda değer bir gelişme sağlanacağını göstermektedir

Angio-seal used as a bailout for incomplete hemostasis after dual perclose ProGlide deployment in transcatheter aortic valve implantation

Background: The failure rate of vascular closure devices remains a significant cause of major vascular complications in contemporary transcatheter aortic valve implantation practice. Methods: This research aimed to evaluate use of the Angio-Seal device in a bailout context in the setting of incomplete hemostasis following use of dual Perclose ProGlide devices in patients undergoing transfemoral transcatheter aortic valve implantation. A total of 185 patients undergoing transfemoral transcatheter aortic valve implantation with either dual Per-close ProGlide (n = 139) or a combination of dual Perclose ProGlide and Angio-Seal (n = 46) were retrospectively analyzed. The baseline, procedural characteristics, and all outcomes (defined according to Valve Academic Research Consortium-2 criteria) were compared. Results: No significant differences were seen between the dual Perclose ProGlide vs dual Perclose ProGlide+Angio-Seal groups with regard to the in-hospital Valve Academic Research Consortium-2 primary end points of major vascular complications (n = 13 [9.4%] vs n = 2 [4.3%]; P =.36), minor vascular complications (n = 13 [9.4%] vs n = 8 [14.7%]; P =.14), major bleeding (n = 16 [11.5%] vs n = 2 [4.3%]; P =.25), and minor bleeding (n = 9 [6.5%] vs n = 5 [10.9%]; P =.34), with higher rates of hematoma in the dual Perclose ProGlide+Angio-Seal group (n = 4 [2.9%] vs n = 5 [10.9%]; P =.044). Conclusion: Finding from the current study suggest that adjunctive Angio-Seal deployment may be feasible and safe, especially in patients with incomplete hemostasis following dual Perclose ProGlide use, and can be an optimal “bailout” procedure. (Tex Heart Inst J. 2022;49(6):e217684)

Polymorphisms of the DNA repair gene XPD (751) and XRCC1 (399) correlates with risk of hematological malignancies in Turkish population

Polymorphisms that occur in DNA repair genes affect DNA repair capacity and constitute a risk factor in hematological malignancies. This study, was aimed to investigate whether xeroderma pigmentosum complementation group D (XPD) and x-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms were involved in the susceptibility to different hematological malignancies. The genotype and allele frequencies were obtained by analyzing XPD gene codon 751 in a total of 80 patients and XRCC1 gene codon 399 polymorphism in a total of 100 patients with hematological malignancies and 100 healthy controls. Mean age was 45 (range: 16 to 75) and 46 (range: 16 to 82) in the patients groups and 39.5 (range: 18 to 67) in the control group, respectively. Additionally, distribution of genotypes and alleles were compared in the patient and control groups. In the comparison of genotype and allele frequencies in hematological malignancies and healthy controls, XPD-751Gln variant was arranged and compared according to age and sex and Gln/Gln genotype was reported to be a protector, which was decreased significantly in acute myeloblastic leukemia (AML) (p = 0.042). No relationship was determined between allele frequencies (p = 0.054). In XRCC1-399, it was shown that Gln/Gln genotype was decreased significantly in AML (p = 0.014) plus all hematological malignancies (p = 0.033) and that Gln allele was present at a lower ratio in AML (p = 0.046). The distribution of polymorphism of both genes was not statistically significant in terms of age and sex. In leukemia with early relapse, XPD 751 Lys/Lys genotype was determined at a statistically higher ratio (p = 0.042). In the evaluation of both genes together, a decrease was noted in Gln/Gln + Lys/Gln haplotype frequency in hematological malignancies (p = 0.048). In this study, it was demonstrated that a decrease in Gln/Gln genotype and Gln allele acted as a protector in XPD codon 751 and XRCC1 codon 399 polymorphisms in acute myeloblastic leukemia (AML) and that an increase in Lys/Lys genotype in acute leukemia was associated with early relapse

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Effect of dietary lipase and proteaz supplementation on growth performance, and body composition and digestive enzyme activities in gilthead sea bream (Sparus aurata linnaeus 1758).

TEZ10937Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2015.Kaynakça (s. 105-123) var.x, 125 s. : res. (bzs. rnk.), tablo ; 29 cm.Bu çalışma 2 denemeden oluşmuştur. Denemelerde lipit oranı %14 - % 22 olan ve protein oranı %40 - % 50 olan yemlere farklı seviyelerde lipaz ve proteaz (0.5, 1, 1.5 ve 2 g/kg yem) enzimleri ilavesinin çipuraların (Sparus aurata), büyüme performansı, sindirim enzimleri aktivitesi ve vücut kimyasal kompozisyonlarına etkileri araştırılmıştır. Bu amaçla, (ortalama başlangıç ağırlıkları 7.72±0.05 g olan) herbir tanka (450L) otuzbeş adet çipura yavrusu 3 tekerrürlü olacak şekilde stoklanmış ve deneme 60 günlük bir peryotta sürdürülmüştür. I.Deneme sonucunda, DL-0.5 grubunda son canlı ağırlık (SCA) 64.42±1.06 g , spesifik büyüme oranı (SBO) 3.55±0.01, yem çevirim oranı (YÇO) 1.20±0.18, olarak diğer gruplara nazaran daha iyi bulunmuştur (P<0.05). II.Deneme sonucunda ise YP-0.5 grubunda son canlı ağırlık (SCA) 52.38±0.70 g, spesifik büyüme oranı (SBO) 3.18±0.02, yem çevirim oranı (YÇO) 1.17±0.03, olarak diğer gruplara nazaran daha iyi bulunmuştur (P<0.05). Bununla birlikte, sindirim kapasitesi en iyi olan grupların ilk denemede DL-0.5, ikinci deneme de YP-0.5 olduğu gözlenmiştir. Proteaz, Tripsin ve alkalin fosfataz aktiviteleri, büyümeyi destekler nitelikte olup, aktivitelerinde deneme boyunca artış görülmüştür.Amilaz, Lipaz ve Aminopeptidaz aktivitelerinde ise deneme boyunca azalma saptanmıştır. Sonuç olarak, çipura yavrularının yemlerinde lipaz (0.5g / kg, % 14 lipid) ve proteaz enzimlerinin (0.5g/kg, % 50 protein) belirtilen lipit ve protein oranlarında eklenmesi çipura yetiştiriciliği için önerilmektedir.This study is composed by two experiments. Nutrition trials were carried out to investigate the effects of inclusion of lipase and protease enzymes (0.5, 1, 1.5 and 2 g/kg diet) at different dietary lipid levels (%14 and %22) and different protein levels (%40 and % 50) on growth performance, feed utilization body composition, digestive enzyme activity of fingerlings gilthead seabream (Sparus aurata). Thirty-five gilthead sea bream juveniles (average body weight was 7.72±0.05 g ) were stocked into each tanks (450 L) as triplicate and experiments lasted for 60 days. At the end of first the experiment, final body weight (FBW) 64.42±1.06 g, specific growth ratio (SGR) 3.55±0.01, feed conversion rate (FCR) 1.20±0.18, were found better in LL-0.5 than those the other groups (P<0.05). At the end of second the experiment final body weight (FBW) 52.38±0.70 g, specific growth ratio (SGR) 3.18±0.02, feed conversion rate (FCR) 1.17±0.03, were found better in HP-0.5 than those the other groups (P<0.05). In addition, whole-body protein, dry matter and fat levels were statistically different in the LL-0.5 and HP-0.5 groups at two experiments (P<0.05). LL-0.5 and HP-0.5 groups showed the best digestive capacity compared to averages of the treatment groups (P<0.05). An increase in Protease, Trypsine and Alkaline Phosphatase enzyme activity were observed as a function of growth from the until the end of the experiments at LL- 0.5 and HP-0.5 groups. Amilase, Lipase and Aminopeptidase activities observed in the LL-0.5 and HP-0.5 groups were lower than those the other groups. The using of lipaz (0.5g / kg, % 14 lipid) and protease enzyme (0.5g/kg, % 50 protein) in sea bream juveniles diets could be recommended for intensive sea bream culture.Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: SÜF2011D6

Küçük Menderes basin in the National Struggle (1919-1923)

Milli Mücadele yıllarında (1919'1922) Küçük Menderes Havzası'nda Yunan işgaline bir başkaldırı olarak ortaya çıkan Kuva-yi Milliye hareketi, bunun nasıl, hangi şartlarda ve kimlerin katılımı ve desteğiyle gerçekleştiği anlatılmaya çalışılmıştır. Ayrıca işgalin ve Kuva-yi Milliye hareketinin bölge halkına etkileri üzerinde durulmuştur. Birinci bölümde Küçük Menderes Havzasının o dönemde içinde bulunduğu sosyal şartlar üç başlık altında incelenerek ortaya konulmuştur. İkinci bölümde mütareke yıllarından başlayarak işgale kadar geçen zamanda İzmir'in içinde bulunduğu durum ve işgalin gerçekleşme süreci hakkında bilgi verilmiştir. Üçüncü bölümde ise işgalin genişlemeye başlaması ve Ödemiş'e doğru ilerlemesiyle burada yapılan çalışmalara değinilmiştir. Çalışma Küçük Menderes Havzasındaki yerleşim birimlerinin faaliyetlerini akademik bir araştırma ile ilk kez ortaya koyarak, o dönem içinde yaşananlara ışık tutmaktadır.In the National Struggle (1919'1922) Küçük Menderes Basin to the Greek occupation as an contumacy emerging movement of the Nationalist Forces, that's how, in what circumstances and who performed with the participation and support has been trying to described it. In addition to the occupation and movement of the Nationalist Forces focused on its impact on local people. In the first chapter Küçük Menderes Basin in that period at three titles review by the social conditions were revealed. In the second chapter the time until the start of the year truce to the process the ocupation, the situation in İzmir and the occupation to the realization of the process are given information about. In the third chapter the occupation to begin to expand and to move towards Odemis of the work here has been stated. Study Küçük Menderes Basin settlements in the activities of an academic research reveals for the first time and enlightens current events in that period

Vertebral kemik metastazı ile tanısı konan papiller tiroit karsinom olgusu

Papillary carcinoma of the thyroid gland is the most common thyroid malignancy with a good prognosis. These tumors remain asymptomatic for a long time and mostly tend to make metastasis to regional lymph nodes. The involvement of distant organs like lungs and bones is rare and the occurrence of distant metastasis at initial presentation is also unusual. In this report, the clinical course of a patient initially diagnosed with vertebral metastasis of papillary thyroid carcinoma who underwent total thyroidectomy combined with additional therapies is presented. Additionally, the literature data obtained on the clinical course of patients presented with metastatic disease at the time of diagnosis are reviewed.Papiller tiroit kanseri, en sık görülen tiroit malignitesi olup, iyi prognoza sahiptir. Uzun süre sessiz kalan bu tümörler daha çok bölgesel lenf nodlarına metastaz yapma eğilimindedir. Akciğer ve kemik gibi uzak organ metastazı nadir görülmekte ve uzak metastaz ile tanı alan olgulara literatürde oldukça az sayıda rastlanmaktadır. Bu olgu sunumunda nörolojik yakınmaları nedeni ile yapılan tetkiklerinde, torakal vertebralarda tiroit karsinom metastazı saptanan 56 yaşında erkek hastada uygulanan kombine tedavi yaklaşımı ve klinik seyir sunulmaktadır. Ayrıca bu olgu dolayısıyla literatür verileri gözden geçirilerek, tanı anında kemik metastazı bulunan iyi differansiye tiroit kanserlerinin, klinik izlem sonuçları gözden geçirilmektedir