Obstacle Avoidance Cell Discovery using mm-waves Directive Antennas in 5G Networks

With the advent of next-generation mobile devices, wireless networks must be upgraded to fill the gap between huge user data demands and scarce channel capacity. Mm-waves tech- nologies appear as the key-enabler for the future 5G networks design, exhibiting large bandwidth availability and high data rate. As counterpart, the small wave-length incurs in a harsh signal propagation that limits the transmission range. To overcome this limitation, array of antennas with a relatively high number of small elements are used to exploit beamforming techniques that greatly increase antenna directionality both at base station and user terminal. These very narrow beams are used during data transfer and tracking techniques dynamically adapt the direction according to terminal mobility. During cell discovery when initial synchronization must be acquired, however, directionality can delay the process since the best direction to point the beam is unknown. All space must be scanned using the tradeoff between beam width and transmission range. Some support to speed up the cell search process can come from the new architectures for 5G currently being investigated, where conventional wireless network and mm-waves technologies coexist. In these architecture a functional split between C-plane and U-plane allows to guarantee the continuous availability of a signaling channel through conventional wireless technologies with the opportunity to convey context information from users to network. In this paper, we investigate the use of position information provided by user terminals in order to improve the performance of the cell search process. We analyze mm-wave propagation environment and show how it is possible to take into account of position inaccuracy and reflected rays in presence of obstacle

The role of autophagy in osteoclast differentiation and bone resorption function

Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue

Monitoramento Sócio Ambiental da Bacia da Lagoa Mirim (1997 - 2006).

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Runtime Management of Artificial Intelligence Applications for Smart Eyewears

Artificial Intelligence (AI) applications are gaining popularity as they seamlessly integrate into end-user devices, enhancing the quality of life. In recent years, there has been a growing focus on designing Smart EyeWear (SEW) that can optimize user experiences based on specific usage domains. However, SEWs face limitations in computational capacity and battery life. This paper investigates SEW and proposes an algorithm to minimize energy consumption and 5G connection costs while ensuring high Quality-of-Experience. To achieve this, a management software, based on Q-learning, offloads some Deep Neural Network (DNN) computations to the user’s smartphone and/or the cloud, leveraging the possibility to partition the DNNs. Performance evaluation considers variability in 5G and WiFi bandwidth as well as in the cloud latency. Results indicate execution time violations below 14%, demonstrating that the approach is promising for efficient resource allocation and user satisfaction

Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells

In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoforms are known to be more expressed in CSC and metastatic cells than CD44 standard isoform. In agreement, functional analysis of the two sorted and cultured subpopulations has shown that the CD44v8-10pos PC3 cells, resulting from the conversion of the CD44neg subpopulation, were more invasive in vitro and had a higher clonogenic potential than the sorted CD44high cells, in that they produced mainly holoclones, known to be enriched in stem-like cells. Of interest, the CD44v8-10 is more expressed in human PCa biopsies than in normal gland. The discovery of CD44v8-10pos cells with stem-like and invasive features, derived from a minoritarian CD44neg cell population in PCa, alerts on the high plasticity of stem-like markers and urges for prudency on the approaches to targeting the putative CSC

fish freshness decay measurement with a colorimetric artificial olfactory system

Abstract This paper reports about the application of an artificial olfactory system based on optical imaging technology. This arrangement is formed by a distributed layer of chemical indicators illuminated by a computer screen and imaged by a digital camera. The system has been applied to monitor the freshness decay in fish. The set of indicators is formed by porphyrinoids and acid–base indicators, this combination provides an optimal capture of the process with some of the indicators sensitive to first stage, when the product is still fresh, and others more sensitive to the last part of the freshness deca

Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination

Influenza vaccination has been implicated in Guillain Barré Syndrome (GBS) although the evidence for this link is controversial. A case–control study was conducted between October 2010 and May 2011 in seven Italian Regions to explore the relation between influenza vaccination and GBS. The study included 176 GBS incident cases aged ≥18 years from 86 neurological centers. Controls were selected among patients admitted for acute conditions to the Emergency Department of the same hospital as cases. Each control was matched to a case by sex, age, Region and admission date. Two different analyses were conducted: a matched case–control analysis and a self-controlled case series analysis (SCCS). Case–control analysis included 140 cases matched to 308 controls. The adjusted matched odds ratio (OR) for GBS occurrence within 6 weeks after influenza vaccination was 3.8 (95 % CI: 1.3, 10.5). A much stronger association with gastrointestinal infections (OR = 23.8; 95 % CI 7.3, 77.6) and influenza-like illness or upper respiratory tract infections (OR = 11.5; 95 % CI 5.6, 23.5) was highlighted. The SCCS analysis included all 176 GBS cases. Influenza vaccination was associated with GBS, with a relative risk of 2.1 (95 % CI 1.1, 3.9). According to these results the attributable risk in adults ranges from two to five GBS cases per 1,000,000 vaccinations