Contra-referência e renovação de receituário de medicações psiquiátricas: projeto de intervenção

O objetivo do presente trabalho é elaborar um projeto de intervenção para o estabelecimento de uma de rede de atenção resolutiva no cuidado dos pacientes psiquiátricos. Foi realizada uma revisão narrativa de literatura baseada em busca na Biblioteca Virtual em Saúde com os descritores: Transtornos Mentais, Atenção Primária à Saúde e Prescrições

Association of alpha-thalassemia, TNF-alpha (-308GNA) and VCAM-1 (c.1238GNC) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia.

Cerebrovascular disease (CVD) is a severe complication associatedwith sickle cell anemia. Abnormal transcranial Doppler (TCD) identifies some children at high risk, but other markers would be helpful. This cohort study was aimed at evaluating the effects of genetic biomarkers on the risk of developing CVDin children fromMinasGerais, Brazil. Clinical and hematological data were retrieved from children's records. Outcomes studied were overt ischemic stroke and CVD (overt ischemic stroke, transient ischemic attack, abnormal TCD, or abnormal cerebral angiography). Out of 411 children, 386 (93.9%) had SS genotype, 23 (5.6%) had Sβ0-thal and two had severe Sβ+-thal (0.5%). Frequency of CVD was lower in Sβ-thal group (p= 0.05).NoeffectofVCAM-1polymorphism on stroke or CVD risks was detected. Cumulative incidence of stroke was significantly higher for children with TNF-α A allele (p = 0.02) and lower for children with HBA deletion (p = 0.02). However, no association between CVD and TNF-α -308GNA was found. CVD cumulative incidence was significantly lower for children with HBA deletion (p= 0.004). This study found no association between VCAM1 c.1238GNC and stroke. An association between stroke and TNF-α -308A allele has been suggested. Our results have confirmed the protective role of HBA deletion against stroke and CVD

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data