Histochemical polymorphism of keratin pearls in squamous cell carcinoma of the lung

The aim of the research is to study histochemical features of keratin pearls in keratinizing squamous cell carcinoma of lung irrespective of its localization. Methods: histochemical methods of staining have been also used during the investigation: neutral fats stained with Sudan III and with finish hematoxylin staining. Combined histochemical staining has been also used: neutral mucoproteins and acid glycosaminoglycans with PASreaction- alcian blue and PAS-reaction with tionine blue. The results of histological and histochemical analyses detected three types of keratin pearls of different structures and tinctorial features: eosinophilic or tionine-positive, PAS-positive (containing glycogen) and light or sudanophilic (containing lipids). Taking into consideration the obtained data, it can be assumed that tumor clusters with heterogenous keratin pearls by tinctorial features are differed according to the degree of cells’ differentiation, keratinization and related to various stages of tumor progression. Histochemical analyses of keratin pearls are not normally taken into consideration during morphological studies and it is regarded as differentiated keratinizing cancer. However, the results of morphological investigations show that it is necessary to consider histochemical features of cancerous clusters for adequate morphological analysis of tumor progression

The use of torasemide as a stres protector in morphological research of hepatic reaction

Nowadays the negative impact of stress factors on the liver is well-studied and substantiated. However, this issue remains open and priority for medicine, particular attention being paid to the stress protective effect of torasemide saluretics. The use of torasemide as a stress protector in acute stress reactions on the example of the liver has shown the feasibility of its use, as a result of morphological studies

Morfofunzionale sperimentali principi base trattamento di pulpite

Riassumendo i risultati della ricerca si può concludere che i processi di carie superficiali di cambiamento nella polpa sono reversibili e possono scomparire al trattamento terapeutico normale della carie dentale. Decadimento medio caratterizzata dallo sviluppo di reazioni di adattamento della polpa e cambiamenti condizionale reversibili, tattiche terapeutiche in cui devono essere affrontati nel caso specifico con prove cliniche. Con carie profonda sviluppano cambiamenti irreversibili, che possono essere eliminati con l'aiuto di pulpotomia. Carie profonda con perforazione della camera pulpare è caratterizzata da cambiamenti irreversibili in tutte le parti della camera di polpa, che è un'indicazione per pulpectomia

Gastric cancer with multiple metastases in pregnancy: a case report

The mortality rate in gastric cancer during pregnancy is very high, which dictates the need to research and improve the methods of early diagnosis of malignancies, as well as studying the pathogenesis of malignant tumors in pregnant women. We report a lethal case of gastric cancer in a pregnant woman. The findings of the autopsy, histological, histochemical and immunohistochemical examinations verified gastric signet ring cells carcinoma with multiple metastases and infiltration of the placental intervillous space. The possible pathogenesis of cancer with changes in the hormonal background occurring in pregnant women is discussed. Understanding the endocrine mechanisms of carcinoma pathogenesis will be useful for developing new therapies for gastric cancer

Методи оптимізації збереження ланцюжка спадкоємності між викладанням патоморфології та топографічної анатомії в умовах кредитно-модульної системи

Міждисциплінарна інтеграція – один з найважливіших напрямків вдосконалення підготовки студентів в сучасному вузі. Суть її полягає у зростаючій ролі знань людини в області суміжних з майбутньою спеціальністю науках і вміння комплексно застосовувати їх при вирішенні професійних завдань, що дозволить акцентування уваги на головному. Майбутній фахівець повинен володіти вміннями та професійною мобільністю оперативно реагувати на постійно виникаючі зміни в практичній і науковій діяльності. Використання в умовах кредитно - модульної системи інноваційних методів навчання, інтеграційного зв’язку між базовими та клінічними дисциплінами, удосконалення методів контролю теоретичних знань та практичних навичок, отриманих студентами, дозволить сформувати творчу особистість, здатну до самостійної відповідальної праці

Aktualne prace badaczy ukrainskich na temat wplywu stresu na narzady klatki piersiowej: przeglad literatury

Introduction: Stress reactions allow the body to adapt to the various environmental factors using the universal complex of neurohumoral reactions. Excessive stress reduces adaptability of the body and can initiate the onset and development of various pathologies. In recent years, Ukrainian scientists have completed a series of studies on the analysis of various aspects of the stress effect on the body. Aim: The paper was aimed at the analysis of the national medical publications, devoted to the study of the impact of stress on the chest organs. Material and Methods: The bibliosemantic method has been used during the study. Findings of the contemporary scientific studies devoted to the effect of stress on the chest organs have been analyzed. Results: The analysis shows that despite a long history of stress-related investigations, the study of the problem of stress remains relevant to date. Scientific researches elicit the new aspects of the impact of stress on the body, particularly on the chest organs. Conclusion: Recent investigations of Ukrainian scientists assist In better understanding of the essence of the stress-related morphofunctional changes that occur in the lungs, heart and esophagus. The findings will be helpful in the search for ways to prevent and treat stress-induced pathological processes, since the problem of stress remains to be solved to date

Aktualny stan wiedzy na temat budowy i funkcji zatoki czolowej: przeglad literatury

Chronic inflammatory diseases of the mucous membranes of the nose, paranasal sinuses, and pharynx are the most common pathology of the upper airways. Pathological processes develop more often in the maxillary and ethmoidal sinuses than in the frontal ones; however, the clinical course of frontitis is more severe. Fundamental understanding of the specific structure of frontal sinuses Is crucial in the awareness of the precursors of the onset and development of its pathology, the choice of methods of diagnostics and treatment. The paper was aimed at the analysis of the publications on current data related to the structure and functions of the human frontal sinus and its structural components. The bibliosemantic method has been used during the study. Findings of the current research works on the study of the human frontal sinus have been analyzed. The resulting analysis shows that despite the significant amount of research works devoted to the study of the structure and functions of the frontal sinus, the morphofunctional features of its mucosa and the state of local immune protection remained unknown for a long time. Conclusions; The resulting literature review showed that the study of the morphofunctional properties of the frontal sinus is relevant to date that is reflected in the number of research works, elucidating its topographoanatomical, histological, physiological and immunohistochemical features

Advanced technology and traditional means of teaching of pathomorphology in present terms

Для покращення ефективності навчального процесу, на нашу думку, необхідно органічне поєднання традиційних методів навчання з новітніми технологіями. Головною метою цих методів повинно бути засвоєння навчального матеріалу та розвиток клінічного мислення.; In order to improve the learning process, we believe it is necessary organic combination of traditional teaching methods with the latest technology. The main goal of these methods should be learning and the development of clinical thinking

Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide

In Paracoccus denitrificans, three CRP/FNR family regulatory proteins, NarR, NnrR and FnrP, control the switch between aerobic and anaerobic (denitrification) respiration. FnrP is a [4Fe-4S] cluster containing homologue of the archetypal O2 sensor FNR from E. coli and accordingly regulates genes encoding aerobic and anaerobic respiratory enzymes in response to O2, and also NO, availability. Here we show that FnrP undergoes O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion that involves up to 2 O2 per cluster, with significant oxidation of released cluster sulfide to sulfane observed at higher O2 concentrations. The rate of the cluster reaction was found to be ~6-fold lower than that of E. coli FNR, suggesting that FnrP can remain transcriptionally active under microaerobic conditions. This is consistent with a role for FnrP in activating expression of the high O2 affinity cytochrome c oxidase under microaerobic conditions. Cluster conversion resulted in dissociation of the transcriptionally active FnrP dimer into monomers. Therefore, along with E. coli FNR, FnrP belongs to the subset of FNR proteins in which cluster type is correlated with association state. Interestingly, two key charged residues, Arg140 and Asp154, that have been shown to play key roles in the monomer-dimer equilibrium in E. coli FNR are not conserved in FnrP, indicating that different protomer interactions are important for this equilibrium. Finally, the FnrP [4Fe-4S] cluster is shown to undergo reaction with multiple NO molecules, resulting in iron nitrosyl species and dissociation into monomers