15 research outputs found
The significance of the serum leptin, ghrelin, tumor necrosis factor alpha and interleukine-1 levels in patients with non-small cell lung cancer.
Sequential use of bevacizumab and cetuximab in patients with K-RAS wild type advanced colorectal cancer.
The Outcome of Patients with Triple Negative Breast Cancer: The Turkish Oncology Group Experience
Objective:Triple negative breast cancer (TNBC) is generally considered as a poorer prognostic subgroup, with propensity for earlier relapse and visceral involvement. The aim of this study is to evaluate the outcome of non-metastatic TNBC patients from different centers in Turkey and identify clinical and pathologic variables that may effect survival
Baculoviral vector loaded mesenchymal stem cells as efficient gene therapy tools for cancer treatment
Insufficient targeting of the therapeutic genes to tumor cells is one of
the major reasons for failure in cancer gene therapy. Mesenchymal stem
cells (MSCs) seem to be a good candidate as a carrier for gene therapy
because of its selective tumor tissue-homing properties. In the current
study, we constructed baculoviral vectors (BVs) carrying cytosine
deaminase (CD) (BV-CD) or green fluorescence protein (GFP) genes
(BV-GFP) and tested the transduction efficiency of the vectors in tumor
and mesenchymal stem cells. We also tested the in vivo efficacy of the
BV-CD vector in a colon cancer model. Our results showed that the
recombinant baculoviral vectors can efficiently transduce mammalian
cells and express genes of interest. The BV-CD vector treatment caused
significant in vitro cytotoxicity when used with 5-fluorocytosine. MSCs
loaded with the BV-CD vector caused a significant delay in tumor growth
and increased survival when compared to control and MSC alone treated
groups bearing colon cancer.
Our results show that the recombinant BV-CD vector could be used either
alone or loaded into MSCs in the treatment of established tumors