Atypical Antipsychotic-Induced Parkinsonism: A Patient Case with CYP Enzyme Implications

Objective: To report a case of Parkinsonism potentially caused by neuroleptic medications. Summary: The case analyzed is that of a 57-year-old male patient referred to a pharmacotherapy service by a neurologist after organic causes of tremor had been ruled out. Iatrogenic cause was suspected and referral expectation was to identify the offending agent or agents and propose alternative therapy. Conclusion: This case illustrates iatrogenic risk associated with neuroleptic medications while illustrating mechanisms of drug interaction via CYP enzymes that can lead to iatrogenic disease. Abbreviations: DIP = Drug-induced Parkinsonism; MTM = Medication Therapy Management; PD = Parkinson’s Disease   Type: Clincial Experienc

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

A joint Fermi-GBM and Swift-BAT analysis of gravitational-wave candidates from the third gravitational-wave observing run

We present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational-wave (GW) candidate events identified during the third observing run of the Advanced LIGO and Advanced Virgo detectors. Using Fermi-GBM onboard triggers and subthreshold gamma-ray burst (GRB) candidates found in the Fermi-GBM ground analyses, the Targeted Search and the Untargeted Search, we investigate whether there are any coincident GRBs associated with the GWs. We also search the Swift-BAT rate data around the GW times to determine whether a GRB counterpart is present. No counterparts are found. Using both the Fermi-GBM Targeted Search and the Swift-BAT search, we calculate flux upper limits and present joint upper limits on the gamma-ray luminosity of each GW. Given these limits, we constrain theoretical models for the emission of gamma rays from binary black hole mergers

Adaptive forward error correction for MPEG streaming video

To achieve optimal performance, streaming video requires a TCP-friendly data rate as well as resistance to lost packets. This project implements an adaptive forward error correction (AFEC) system with temporal scaling for streaming MPEG, which repairs video frames in the event of packet loss. Data is transferred via a TCP-friendly UDP flow which responds to network conditions to reduce congestion and optimize performance. Adaptive FEC is comparable in performance to fixed FEC, and in some test cases, outperforms it

Internet marketing to children.

This project was an examination of the quality of websites that market to children younger than fourteen. After researching the current laws and concerns of the public, we constructed a questionnaire with which we collected data on a large sample of websites. Analysis of the data allowed us to come to some conclusions about the current state of Internet marketing directed at children. From these findings, we created guidelines and recommendations for Internet marketers to more responsibly market to children

Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies

von Figura K, Schmidt B, Dierks T, Heartlein M, Ballabio A, Cosma MP. Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies. 2004

Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis

D'Hooge R, Lüllmann-Rauch R, Beckers T, et al. Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human  α-Mannosidosis. Journal of Neuroscience. 2005;25(28):6539-6549