Atypical Antipsychotic-Induced Parkinsonism: A Patient Case with CYP Enzyme Implications

Objective: To report a case of Parkinsonism potentially caused by neuroleptic medications. Summary: The case analyzed is that of a 57-year-old male patient referred to a pharmacotherapy service by a neurologist after organic causes of tremor had been ruled out. Iatrogenic cause was suspected and referral expectation was to identify the offending agent or agents and propose alternative therapy. Conclusion: This case illustrates iatrogenic risk associated with neuroleptic medications while illustrating mechanisms of drug interaction via CYP enzymes that can lead to iatrogenic disease. Abbreviations: DIP = Drug-induced Parkinsonism; MTM = Medication Therapy Management; PD = Parkinson’s Disease   Type: Clincial Experienc

Adaptive forward error correction for MPEG streaming video

To achieve optimal performance, streaming video requires a TCP-friendly data rate as well as resistance to lost packets. This project implements an adaptive forward error correction (AFEC) system with temporal scaling for streaming MPEG, which repairs video frames in the event of packet loss. Data is transferred via a TCP-friendly UDP flow which responds to network conditions to reduce congestion and optimize performance. Adaptive FEC is comparable in performance to fixed FEC, and in some test cases, outperforms it

Internet marketing to children.

This project was an examination of the quality of websites that market to children younger than fourteen. After researching the current laws and concerns of the public, we constructed a questionnaire with which we collected data on a large sample of websites. Analysis of the data allowed us to come to some conclusions about the current state of Internet marketing directed at children. From these findings, we created guidelines and recommendations for Internet marketers to more responsibly market to children

Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies

von Figura K, Schmidt B, Dierks T, Heartlein M, Ballabio A, Cosma MP. Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies. 2004

Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis

D'Hooge R, Lüllmann-Rauch R, Beckers T, et al. Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human  α-Mannosidosis. Journal of Neuroscience. 2005;25(28):6539-6549

Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine

Dierks T, Miech C, Hummerjohann J, Schmidt B, Kertesz MA, Figura von K. Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine. JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(40):25560-25564.Eukaryotic sulfatases carry an alpha-formylglycine residue that is essential for activity and is located within the catalytic site. This formylglycine is generated by posttranslational modification of a conserved cysteine residue. The arylsulfatase gene of Pseudomonas aeruginosa also encodes a cysteine at the critical position. This protein could be expressed in active form in a sulfatase-deficient strain of P. aeruginosa, thereby restoring growth on aromatic sulfates as sole sulfur source, and in Escherichia coli, Analysis of the mature protein expressed in E. coli revealed the presence of formylglycine at the expected position, showing that the cysteine is also converted to formylglycine in a prokaryotic sulfatase. Substituting the relevant cysteine by a serine codon in the P. aeruginosa gene led to expression of inactive sulfatase protein, lacking the formylglycine. The machinery catalyzing the modification of the Pseudomonas sulfatase in E. coli therefore resembles the eukaryotic machinery, accepting cysteine but not serine as a modification substrate, By contrast, in the arylsulfatase of Klebsiella pneumoniae a formylglycine is found generated by modification of a serine residue. The expression of both the Klebsiella and the Pseudomonas sulfatases as active enzymes in E. coli suggests that two modification systems are present, or that a common modification system is modulated by a cofactor

Rates of pathologic complete or near complete response following neoadjuvant chemotherapy and stereotactic body radiation therapy for borderline resectable pancreatic cancer

221 Background: While the clinical response from induction chemotherapy followed by stereotactic body radiation therapy (SBRT) has been reported for borderline resectable pancreatic cancer (BRPC) patients, response from a histopathologic standpoint has not been described. Methods: This single-institution retrospective review evaluated BRPC patients who completed induction gemcitabine-based chemotherapy followed by 5-fraction SBRT. All patients were restaged and underwent resection. A pathologist (B.C.) specializing in pancreatic cancer reviewed each surgical specimen and assigned two Tumor Regression Grade (TRG) scores, one from the College of American Pathologists (CAP) and one from the MD Anderson Cancer Center (MDACC). Overall survival (OS) and progression free survival (PFS) were correlated to TRG score using the Kaplan-Meier method. Results: This study evaluated 35 resected BRPC patients with a median follow up of 13.8 months (range, 6.1-24.8). All received induction gemcitabine-based chemotherapy, most commonly GTX (gemcitabine, docetaxel, capecitabine) (82%), followed by 5-fraction SBRT with a median 35 Gy (range, 30-40). TRG scores according to the CAP were as follows, from best to worst response: 0 (n=3), 1 (n=13), 2 (n=15), and 3 (n=4). TRG scores according to MDACC were as follows, from best to worst response: IV (n=3), III(M) (n=6), IIB (n=11), IIA (n=10), and I (n=5). Any neoadjuvant treatment effect according to MDACC scoring (IIA-IV vs. I) was associated with improved OS and PFS (both p=0.019). Conclusions: This study demonstrated a significant pathologic response with a gemcitabine based neoadjuvant regimen containing SBRT and suggests a survival benefit based on response as measured by the MDACC scoring system

Microsoft Word - KuhlowPaper200u

Diabetes mellitus is the most prevalent metabolic disorder, and its metabolic hallmark, glucose intolerance, affects approximately 344 million people worldwid