Cyanobacterial lipopolysaccharides and human health – a review

Cyanobacterial lipopolysaccharide/s (LPS) are frequently cited in the cyanobacteria literature as toxins responsible for a variety of heath effects in humans, from skin rashes to gastrointestinal, respiratory and allergic reactions. The attribution of toxic properties to cyanobacterial LPS dates from the 1970s, when it was thought that lipid A, the toxic moiety of LPS, was structurally and functionally conserved across all Gram-negative bacteria. However, more recent research has shown that this is not the case, and lipid A structures are now known to be very different, expressing properties ranging from LPS agonists, through weak endotoxicity to LPS antagonists. Although cyanobacterial LPS is widely cited as a putative toxin, most of the small number of formal research reports describe cyanobacterial LPS as weakly toxic compared to LPS from the Enterobacteriaceae. We systematically reviewed the literature on cyanobacterial LPS, and also examined the much lager body of literature relating to heterotrophic bacterial LPS and the atypical lipid A structures of some photosynthetic bacteria. While the literature on the biological activity of heterotrophic bacterial LPS is overwhelmingly large and therefore difficult to review for the purposes of exclusion, we were unable to find a convincing body of evidence to suggest that heterotrophic bacterial LPS, in the absence of other virulence factors, is responsible for acute gastrointestinal, dermatological or allergic reactions via natural exposure routes in humans. There is a danger that initial speculation about cyanobacterial LPS may evolve into orthodoxy without basis in research findings. No cyanobacterial lipid A structures have been described and published to date, so a recommendation is made that cyanobacteriologists should not continue to attribute such a diverse range of clinical symptoms to cyanobacterial LPS without research confirmation

General and specific combining ability in sweet sorghum.

In breeding of sweet sorghum hybrids, non-additive genetic effects are important in phenotypic expression of the traits of interest. The aim of this study was to evaluate the general combining ability (GCA) of sweet sorghum lines and the specific combining ability (SCA) of the hybrids for agronomic and technological traits. Five fertility restorer lines, four male-sterile lines, and their hybrids from partial diallel crosses were evaluated in experiments laid out in a 5 x 6 triple rectangular lattice design in the municipalities of Lavras, MG and Sete Lagoas, MG, Brazil. Diallel analysis was performed using the Griffing model adapted to partial diallel crosses. There was a significant effect of GCA and SCA for most of the traits evaluated, indicating the participation of additive or dominant genes in inheritance. The restorer lines CMSX508, BRS 511, CMSXS643, and CMSXS646 show potential for use as parents in sorghum breeding programs