34 research outputs found
Avalanche of Bifurcations and Hysteresis in a Model of Cellular Differentiation
Cellular differentiation in a developping organism is studied via a discrete
bistable reaction-diffusion model. A system of undifferentiated cells is
allowed to receive an inductive signal emenating from its environment.
Depending on the form of the nonlinear reaction kinetics, this signal can
trigger a series of bifurcations in the system. Differentiation starts at the
surface where the signal is received, and cells change type up to a given
distance, or under other conditions, the differentiation process propagates
through the whole domain. When the signal diminishes hysteresis is observed
Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells
The α-mannosidase I inhibitor kifunensine inhibited N-glycan processing in long-term cultures of Chinese hamster ovary cells, allowing deglycosylation and crystallization of the homodimeric extracellular region of the inhibitory glycoprotein receptor CTLA-4 (CD152)
Measuring the Customer-centric Quality in Agro-product: Development of the Scale with Implications
An Adeno-Associated Virus (AAV) Initiator Protein, Rep78, Catalyzes the Cleavage and Ligation of Single-Stranded AAV ori
Characteristics Associated With Genital Herpes Testing Among Young Adults: Assessing Factors From Two National Data Sets
From crude law to civil relations: The dynamics and potential resolution of intractable conflict.
A survey of the supportive care needs of informal caregivers of adult bone marrow transplant patients
Purpose: This study aims to describe the supportive care needs of informal caregivers (ICG) of adult bone marrow transplant (BMT) patients. In addition, we explored relationships between levels of unmet need, psychological morbidity and patient and ICG characteristics. Methods and sample: We invited patients within 24 months of BMT to participate in a cross-sectional survey. Consenting patients asked their ICG to complete and return the questionnaire booklet. Measures included the Supportive Care Needs Survey Partners and Carers and General Health Questionnaire. Key results: Two hundred patients were approached, and 98 completed questionnaires were received (response rate∈=∈49 %). We found high unmet need and psychological morbidity among ICGs and an association between ICG unmet need and psychological morbidity. Patient functioning, particularly anxiety and depression, sexual dysfunction and resumption of usual activities impacted on ICG unmet need and psychological morbidity. No associations were found between ICG unmet need and psychological morbidity and the following variables: type of BMT, time from BMT, ICG gender, number of dependents and patient age. Conclusion: ICG of BMT patients have high levels of unmet need and psychological morbidity in the months that follow a BMT. This highlights the importance of thorough needs assessment to ensure limited resources are targeted to those most in need. © 2012 Springer-Verlag Berlin Heidelberg