The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons

Background - Both genetic and environmental factors affect the risk of colorectal cancer (CRC). Objective - We aimed to examine the interaction between the D1822V polymorphism of the APC gene and dietary intake in persons with CRC. Design - Persons with CRC (n = 196) and 200 healthy volunteers, matched for age and sex in a case-control study, were evaluated with respect to nutritional status and lifestyle factors and for the D1822V polymorphism. Results - No significant differences were observed in energy and macronutrient intakes. Cases had significantly (P < 0.05) lower intakes of carotenes, vitamins C and E, folate, and calcium than did controls. Fiber intake was significantly (P = 0.004) lower in cases than in controls, whereas alcohol consumption was associated with a 2-fold risk of CRC. In addition, cases were significantly (P = 0.001) more likely than were controls to be sedentary. The homozygous variant for the APC gene (VV) was found in 4.6% of cases and in 3.5% of controls. Examination of the potential interactions between diet and genotype found that a high cholesterol intake was associated with a greater risk of colorectal cancer only in noncarriers (DD) of the D1822V APC allele (odds ratio: 1.66; 95% CI: 1.00, 2.76). In contrast, high fiber and calcium intakes were more markedly associated with a lower risk of CRC in patients carrying the polymorphic allele (DV/VV) (odds ratio: 0.50; 95% CI: 0.27, 0.94 for fiber; odds ratio: 0.51; 95% CI: 0.28, 0.93 for calcium) than in those without that allele. Conclusion - These results suggest a significant interaction between the D1822V polymorphism and the dietary intakes of cholesterol, calcium, and fiber for CRC risk

Drug overdose deaths in Brazil between 2000 and 2020: an analysis of sociodemographics and intentionality

Objectives: To examine drug overdose records in Brazil from 2000 to 2020, analyzing trends over time in overdoses and overall sociodemographic characteristics of the deceased. Methods: Using data from the Brazilian Mortality Information System (Sistema de Informações sobre Mortalidade), we identified records from 2000-2020 in which the underlying cause-of-death was one of the following codes: X40-X45 (accidental poisoning), X60-X65 (intentional poisoning), or Y10-Y15 (undetermined intentionality poisoning). The Brazilian dataset included 21,410 deaths. We used joinpoint regression analysis to assess changes in trends over time. Results: People who died of drug overdoses in Brazil between 2000 and 2020 had a mean age of 38.91 years; 38.45% were women, and 44.01% were identified as White. Of the overdose deaths, 44.70% were classified as intentional and 32.12% were classified as unintentional. Among the identified drugs, stimulants were the most common class. However, most records did not report which drug was responsible for death. Conclusion: Sociodemographic trends in overdose deaths in Brazil must guide country-specific policies. Nevertheless, data collection protocols must be improved, particularly regarding the drug used in overdoses

IOT and cloud-based technologies for efficient use of resources in almonds crop - The Veratech project

Efficient use of resources is a critical factor in almond crops. Technological solutions can significantly contribute to this purpose. The VeraTech project aims to explore the integration of sensors and cloud-based technologies in almond crops for efficient use of resources and reduction of environmental impact. It also makes available a set of relevant and impactful performance indicators in agricultural activity, which promote productivity gains supported by efficient use of resources. The proposed solution includes a sensor network in the almond crops, the transmission of data and its integration in the cloud, making this data available to be consumed, processed, and presented in the monitoring and alerts dashboard. In the current state of the development, several data are collected by sensors, transmitted over LoRaWAN, integrated using AWS IoT Core, and monitored and analysed through a cloud business analytics service. This project is implemented on a farm located in the Beira-Baixa region of Portugal and involves a partnership between Vera Cruz (owner of the farm), Veratech, and the Polytechnic Institute of Castelo Branco.info:eu-repo/semantics/publishedVersio

Trends on communication, educational assessment, sustainable development, educational innovation, mechatronics and learning analytics at TEEM 2022

[EN] The 10th edition of the Technological Ecosystems for EnhancingMulticulturality (TEEM 2022) brings together researchers and postgraduate students interested in combining different aspects of the technology applied to knowledge society development, with particular attention to educational and learning issues. This volume includes contributions related to communication, educational assessment, sustainable development, educational innovation, mechatronics, and learning analytics. Besides, the doctoral consortium papers close the proceedings book from a transversal perspective