Synthesis of novel 1,2,3-triazolic compounds derived from natural product, by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition

A series of novel 1,2,3-triazolic compounds derived from natural products (thymol, carvacrol and eugenol) was synthesized by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition between the corresponding propargyl ethers of each natural product and a variety of azides. The reaction conducted with catalytic amount of copper (II) sulfate and sodium ascorbate affording desired products in good yields and their structures were confirmed by spectral techniques such as 1H NMR, 13C NMR and high resolution mass spectrometry ( HRMS)