Problematika Transaksi Kliring Pada Unit Kerja Teller Di Pt. Bank Rakyat Indonesia (Persero) Tbk, Kantor Cabang Jember

Pada penelitian ini penulis mengambil judul “Problematika Transaksi Kliring Pada Unit Kerja Teller Di PT. Bank Rakyat Indonesia (Persero), Tbk Kantor Cabang jember”. Tujuan dalam penulisan ini adalah untuk mengetahui dan memahami Permasalahan transaksi kliring yang terjadi pada saat transaksi kliring berjalan dan solusi untuk mengatasi permasalahan yang terjadi. Penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengumpulan data yaitu dengan interview dan dokumentasi, dengan sumber data primer dan sekunder. Hasil penelitian ini adalah pelaksanaan sistem kliring yang digunakan PT. Bank Rakyat Indonesia (Persero), Tbk Kantor Cabang jember telah menjalankan sistem pelaksanaan kliring sesuai dengan aturan yang telah ditetapkan oleh BI. Namun, masih terdapat beberapa masalah atau problematika saat pelaksanaan kliring berlangsung dan problematika tersebut menjadi faktor penghambat dalam proses pelaksanaan kliring. Berbagai alternatif penyelesaian terus diupayakan oleh PT. Bank Rakyat Indonesia (Persero), Tbk Kantor Cabang jember salah satunya dengan melakukan pengecekan warkat serta menggunakan sistem kliring bilateral demi mewujudkan penyelenggaraan yang efisien

Molecular targets of aspirin and cancer prevention

Salicylates from plant sources have been used for centuries by different cultures to treat a variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic acid, aspirin, was synthesised and mass produced by the end of the 19th century and is one of the most widely used drugs in the world. Its cardioprotective properties are well established; however, recent evidence shows that it can also act as a chemopreventive agent. Its antithrombotic and anti-inflammatory actions occur through the inhibition of cyclooxygenases. The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed. This review presents a brief account of the major COX-dependent and independent pathways described in connection with aspirin's anticancer effects. Aspirin's unique ability to acetylate biomolecules besides COX has not been thoroughly investigated nor have all the targets of its primary metabolite, salicylic acid been identified. Recent reports on the ability of aspirin to acetylate multiple cellular proteins warrant a comprehensive study to investigate the role of this posttranslational modification in its anticancer effects. In this review, we also raise the intriguing possibility that aspirin may interact and acetylate cellular molecules such as RNA, and metabolites such as CoA, leading to a change in their function. Research in this area will provide a greater understanding of the mechanisms of action of this drug