1,869 research outputs found
The Celestial Reference Frame at 24 and 43 GHz. II. Imaging
We have measured the sub-milli-arcsecond structure of 274 extragalactic
sources at 24 and 43 GHz in order to assess their astrometric suitability for
use in a high frequency celestial reference frame (CRF). Ten sessions of
observations with the Very Long Baseline Array have been conducted over the
course of 5 years, with a total of 1339 images produced for the 274
sources. There are several quantities that can be used to characterize the
impact of intrinsic source structure on astrometric observations including the
source flux density, the flux density variability, the source structure index,
the source compactness, and the compactness variability. A detailed analysis of
these imaging quantities shows that (1) our selection of compact sources from
8.4 GHz catalogs yielded sources with flux densities, averaged over the
sessions in which each source was observed, of about 1 Jy at both 24 and 43
GHz, (2) on average the source flux densities at 24 GHz varied by 20%-25%
relative to their mean values, with variations in the session-to-session flux
density scale being less than 10%, (3) sources were found to be more compact
with less intrinsic structure at higher frequencies, and (4) variations of the
core radio emission relative to the total flux density of the source are less
than 8% on average at 24 GHz. We conclude that the reduction in the effects due
to source structure gained by observing at higher frequencies will result in an
improved CRF and a pool of high-quality fiducial reference points for use in
spacecraft navigation over the next decade.Comment: 63 pages, 18 figures, 6 tables, accepted by the Astronomical Journa
Effect of type of otolith and preparation technique on age estimation of larval and juvenile spot (Leiostomus xanthurus)
Otoliths of larval and juvenile fish provide a record of age, size, growth, and development (Campana and Neilson,
1985; Thorrold and Hare, 2002). However, determining the time of first increment formation in otoliths (Campana, 2001) and assessing the accuracy (deviation from real age)
and precision (repeatability of increment counts from the same otolith) of increment counts are prerequisites for using otoliths to study the life history of fish (Campana and Moksness, 1991). For most fish species, first increment deposition occurs either at hatching, a day after hatching, or after first feeding and yolksac absorption (Jones, 1986; Thorrold and Hare, 2002). Increment deposition before
hatching also occurs (Barkmann and Beck, 1976; Radtke and Dean, 1982). If first increment deposition does not occur at hatching, the standard procedure is to add a predetermined number to increment counts to estimate fish age (Campana and Neilson, 1985)
Consonant and syllable complexity of toddlers with Down syndrome and mixed-aetiology developmental delays
This study examines whether speech sound production of toddlers with Down syndrome (DS) is on par with or more severely impaired than that of mental age (MA) peers with developmental delay due to aetiologies other than Down syndrome at two points within an 18-month period near the onset of spoken word production. The utterances of 26 children with DS, aged 24–33 months, with a mean MA of 14.3 months, originally studied by Fey et al. (2006) and Warren et al. (2008) were compared to those of a group of 22 children with similar intellectual and communication delay but no DS (NDS). Phonological measures included the size of the consonant inventory, syllable shape complexity, and number of communication acts with canonical vocalizations. At Time 1, the DS group performed as well as or better than the NDS group on these measures of speech production. At Time 2, 18 months later, the DS group was behind the NDS group on the same measures. Results extended the pattern of more severe impairment in children with DS than NDS peers commonly noted in expressive language to measures of phonological development
The Gaussian Plasma Lens in Astrophysics. Refraction
We consider the geometrical optics for refraction of a distant radio source
by an interstellar plasma lens, with application to a lens with a Gaussian
electron column density profile. The refractive properties of the lens are
specified completely by a dimensionless parameter, alpha, which is a function
of the wavelength of observation, the lens' electron column density, the
lens-observer distance, and the transverse diameter of the lens. Relative
motion of the observer and lens produces modulations in the source's light
curve. Plasma lenses are diverging so the light curve displays a minimum, when
the lens is on-axis, surrounded by enhancements above the unlensed flux
density. Lensing can also produce caustics, multiple imaging, and angular
position wander of the background source. If caustics are formed, the
separation of the outer caustics can constrain alpha, while the separation of
the inner caustics can constrain the size of the lens. We apply our analysis to
0954+654, a source for which we can identify caustics in its light curve, and
1741-038, for which polarization observations were obtained during and after
the scattering event. We find general agreement between modelled and observed
light curves at 2.25 GHz, but poor agreement at 8.1 GHz. The discrepancies may
result from a combination of lens substructure or anisotropic shape, a lens
that only grazes the source, or unresolved source substructure. Our analysis
places the following constraints on the lenses: Toward 0954+654 (1741-038) the
lens was 0.38 AU (0.065 AU) in diameter, with a peak column density of 0.24 pc
cm^{-3} (1E-4 pc cm^{-3}) and an electron density of 1E5 cm^{-3} (300 cm^{-3}).
The angular wander caused by the lens was 250 mas (0.4 mas) at 2.25 GHz. For
1741-038, we place an upper limit of 100 mG on the lens' magnetic field.Comment: 26 pages, LaTeX2e using AASTeX macro aaspp4, 11 PostScript figures;
to be published in Ap
The approach to criticality in sandpiles
A popular theory of self-organized criticality relates the critical behavior
of driven dissipative systems to that of systems with conservation. In
particular, this theory predicts that the stationary density of the abelian
sandpile model should be equal to the threshold density of the corresponding
fixed-energy sandpile. This "density conjecture" has been proved for the
underlying graph Z. We show (by simulation or by proof) that the density
conjecture is false when the underlying graph is any of Z^2, the complete graph
K_n, the Cayley tree, the ladder graph, the bracelet graph, or the flower
graph. Driven dissipative sandpiles continue to evolve even after a constant
fraction of the sand has been lost at the sink. These results cast doubt on the
validity of using fixed-energy sandpiles to explore the critical behavior of
the abelian sandpile model at stationarity.Comment: 30 pages, 8 figures, long version of arXiv:0912.320
BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation
Background
Inhibitors of apoptosis (IAPs) were intensively investigated in the context of cancer where they promote tumor growth and chemoresistence. Overexpression of the IAP BIRC6 is associated with unfavorable clinical features and negatively impacts relapse-free survival in childhood acute myeloid leukemia (AML). Currently, BIRC6 levels in adult primary AML have not been compared to the expression in normal myeloid cells. Thus, we compared for the first time BIRC6 levels in adult primary AML patient samples to normal myeloid cells and studied its regulation and function during neutrophil differentiation.
Findings
We found significantly lower BIRC6 levels in particular AML subtypes as compared to granulocytes from healthy donors. The lowest BIRC6 expression was found in CD34+ progenitor cells. Moreover, BIRC6 expression significantly increased during neutrophil differentiation of AML cell lines and knocking down BIRC6 in NB4 acute promyelocytic leukemia (APL) cells significantly impaired neutrophil differentiation, but not cell viability.
Conclusion
Together, we found an association of low BIRC6 levels with an immature myeloid phenotype and describe a function for BIRC6 in neutrophil differentiation of APL cells
Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function
TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotrophic lateral sclerosis and ubiquitin-positive frontotemporal lobar degeneration. This TDP-43 pathology is also present in other types of neurodegeneration including Alzheimer's disease. We report here that TDP-43 is a substrate of MEK, a central kinase in the MAPK/ERK signaling pathway. TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramatically increased by the heat shock response (HSR) in human cells. HSR promotes cell survival under proteotoxic conditions by maintaining protein homeostasis and preventing protein misfolding. MEK is activated by HSR and contributes to the regulation of proteome stability. Phosphorylated TDP-43 was not associated with TDP-43 aggregation, and p-T153/Y155 remained soluble under conditions that promote protein misfolding. We found that active MEK significantly alters TDP-43-regulated splicing and that phosphomimetic substitutions at these two residues reduce binding to GU-rich RNA. Cellular imaging using a phospho-specific p-T153/Y155 antibody showed that phosphorylated TDP-43 was specifically recruited to the nucleoli, suggesting that p-T153/Y155 regulates a previously unappreciated function of TDP-43 in the processing of nucleolar-associated RNA. These findings highlight a new mechanism that regulates TDP-43 function and homeostasis through phosphorylation and, therefore, may contribute to the development of strategies to prevent TDP-43 aggregation and to uncover previously unexplored roles of TDP-43 in cell metabolism
Angular Broadening of Intraday Variable AGN. II. Interstellar and Intergalactic Scattering
We analyze a sample of 58 multi-wavelength, Very Long Baseline Array
observations of active galactic nuclei (AGN) to determine their scattering
properties. Approximately 75% of the sample consists of AGN that exhibit
centimeter-wavelength intraday variability (interstellar scintillation) while
the other 25% do not show intraday variability. We find that interstellar
scattering is measurable for most of these AGN, and the typical broadening
diameter is 2 mas at 1 GHz. We find that the scintillating AGN are typically at
lower Galactic latitudes than the non-scintillating AGN, consistent with the
scenario that intraday variability is a propagation effect from the Galactic
interstellar medium. The magnitude of the inferred interstellar broadening
measured toward the scintillating AGN, when scaled to higher frequencies, is
comparable to the diameters inferred from analyses of the light curves for the
more well-known intraday variable sources. However, we find no difference in
the amount of scattering measured toward the scintillating versus
non-scintillating AGN. A consistent picture is one in which the scintillation
results from localized regions ("clumps") distributed throughout the Galactic
disk, but which individually make little contribution to the angular
broadening. Of the 58 AGN observed, 37 (64%) have measured redshifts. At best,
a marginal trend is found for scintillating (non-scintillating) AGN to have
smaller (larger) angular diameters at higher redshifts. We also use our
observations to try to constrain the possibility of intergalactic scattering.
While broadly consistent with the scenario of a highly turbulent intergalactic
medium, our observations do not place significant constraints on its
properties.Comment: 13 pages, 4 figures; AASTeX format; ApJ in pres
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