Effects of topical petrolatum and salicylic acid upon skin photoreaction to UVA

Various agents which can be used in combination can also interfere with phototherapy. In this study, the effects of topical petrolatum and 20% salicylic acid in petrolatum upon skin photoreaction to UVA were investigated, in an in vivo test. Minimal phototoxic dose (MPD) test was performed on 31 volunteers and the test was repeated with thin (0.1 cc/25 cm(2)) petrolatum, thick (0.3 cc/25 cm(2)) petrolatum, thin 20% salicylic acid in petrolatum, thick 20% salicylic acid in petrolatum and sunscreen. The effect of each agent on MPD was investigated. MPD was increased with thin and thick applications of all agents. Also, MPD was increased with 20% salicylic acid in petrolatum when compared with pure petrolatum, in the same thickness. The application of petrolatum and salicylic acid in petrolatum just before PUVA therapy is not recommended because of their blocking effects

Effects of some emollients on the transmission of ultraviolet

Background/purpose: Various topical agents which can be used in combination with phototherapy may have blocking or enhancing effects. In this in vivo study, the effects of topical petrolatum, basis cream, glycerine and olive oil on the transmission of ultraviolet B (UVB) were investigated

Heterogeneous disease: A child case of lichen planus pemphigoides triggered by varicella

PubMedID: 21453319Lichen planus pemphigoides (LPP) is a rare and controversial disease. It is characterized clinically by tense bullae arising both on lichen planus papules and on uninvolved skin, histologically by the demonstration of subepidermal bullae and by linear deposits of immunoglobulin G and C3 along the basement membrane zone on immunofluorescence of peribullous skin. Some authors consider LPP as the combination of lichen planus and bullous pemphigoid. Others think that it most likely encompasses a heterogeneous group of subepidermal autoimmune blistering disorders occurring in association with lichen planus. We present a child case that supports the heterogeneous condition of this disease triggered by varicella. © 2011 Japanese Dermatological Association

Evaluation of metabolic syndrome and its components in patients with rosacea: a cross-sectional, case-control study

Introduction: Previous studies have suggested an association between cardiovascular disease and rosacea. However, there is still a paucity of data regarding its association with metabolic syndrome (MetS). Methods: The components of MetS were evaluated in 100 rosacea patients and 100 controls. Results: MetS was determined in 44% of the rosacea patients and 35% of the controls. Although the difference was not statistically significant (p=0.193), rosacea patients were more likely to have dyslipidaemia (p<0.001), insulin resistance (p=0.035), hypertension (p=0.009), higher atherogenic index (p<0.001) and a higher hypercoagulability (p=0.025) and inflammatory state (p=0.003) compared to controls. Conclusion: The results of this study support that rosacea patients should be screened routinely for the components of MetS such as dyslipidaemia, insulin resistance, hypertension and other cardiovascular risk factors

Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris

Background No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties

Sarcoidosis in a preschooler with only skin and joint involvement

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. It is relatively rare in children less than 15 years of age and especially in those less than 5-6 years of age. Sarcoidosis characteristically involves the skin, eyes, and synovial tissues in patients less than 5-6 years of age. We report a 3-year-old boy with sarcoidosis who had cutaneous findings with joint symptoms. Dermatologic examination revealed lichenoid, erythematous, 2-3 mm papules, some of them grouped, all over his extremities and trunk. There were symmetric swellings on his ankles and wrists without erythema or pain which did not interfere with function. However, until now, no eye involvement had been detected in the patient