CLUMP-3D. Testing Λ\LambdaCDM with galaxy cluster shapes

The $\Lambda$CDM model of structure formation makes strong predictions on concentration and shape of DM (dark matter) halos, which are determined by mass accretion processes. Comparison between predicted shapes and observations provides a geometric test of the $\Lambda$CDM model. Accurate and precise measurements needs a full three-dimensional analysis of the cluster mass distribution. We accomplish this with a multi-probe 3D analysis of the X-ray regular CLASH (Cluster Lensing And Supernova survey with Hubble) clusters combining strong and weak lensing, X-ray photometry and spectroscopy, and the Sunyaev-Zel'dovich effect. The cluster shapes and concentrations are consistent with $\Lambda$CDM predictions. The CLASH clusters are randomly oriented, as expected given the sample selection criteria. Shapes agree with numerical results for DM-only halos, which hints at baryonic physics being not so effective in making halos rounder.Comment: v2: 8 pages, in press on ApJL. Extended discussion on regularity. One of three new companion papers of the CLUMP-3D project (Keiichi Umetsu et al., arxiv:1804.00664; I-Non Chiu et al., arXiv:1804.00676

Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer

<p>Abstract</p> <p>Background</p> <p>Increase of <it>EGFR </it>gene copy number consequent to gene amplification and/or polysomy of chromosome 7 has been significantly associated with better clinical outcome in Non Small Cell Lung Cancer (NSCLC) patients treated with Tyrosin-Kinase Inhibitors (TKIs).</p> <p>The primary method to detect <it>EGFR </it>copy number is FISH (Fluorescence in Situ Hybridization), that in lung cancer requires a precise standardization due to the presence of intratumor heterogeneity and high frequency of chromosome 7 polysomy.</p> <p>Recommendations and interpretative guidelines to discriminate NSCLC patients into FISH positive (gene amplification and high chromosome 7 polysomy) and FISH negative have been proposed by the University of Colorado Cancer Center (UCCC). However, in a subset of cases the distinction between <it>EGFR </it>amplification and chromosome 7 polysomy can be controversial because of a complex pattern of multiple <it>EGFR </it>and centromere signals.</p> <p>Methods</p> <p>In order to distinguish more accurately these two genetic events, 20 NSCLC FISH positive patients, showing a controversial pattern of <it>EGFR </it>and centromere specific signals, were further evaluated for the status of 7q31 distal region.</p> <p>Results</p> <p>A discrepancy between FISH results obtained with UCCC scoring system and 7q31 control was evidenced in 2 patients (10%).</p> <p>Conclusion</p> <p>Our data strengthen the usefulness of 7q31 region evaluation to discriminate EGFR amplification from chromosome 7 polysomy in controversial <it>EGFR </it>FISH positive cases. Since it has been reported a possible different contribution of amplification and polysomy to TKIs susceptibility in NSCLC, the clear distinction between these two genetic events may be important to identify a subset of patients more responsive to the therapy.</p

Mobile Application development for labor intermediation as a solution for sectors excluded from the labor market : An Instrument for the definition of public policies

A social app where local workers can build a reputation based on theirs clients califications. With a strong focus in real life interactions this platform offer a great solution to those who demand a service or product and have interest in compare local options,and also for those who offer a service and want to expand their work opportunities. Registers users can geolocate their working area and detailed their abbilities for free. This project was developed by a workteam established between the National University of Rosario (UNR) and the National University of Río Negro (UNRN). This paper presents technical details of the application and explains the context for its use, as well as associated benefits and necessary technical resources.Sociedad Argentina de Informática e Investigación Operativ

Mobile Application development for labor intermediation as a solution for sectors excluded from the labor market. An instrument for the definition of public policies

Fil: Cambarieri, Mauro. Universidad Nacional de Río Negro. Laboratorio de Informática Aplicada. Río Negro; ArgentinaFil: Garcia Martinez, Nicolás . Universidad Nacional de Río Negro. Laboratorio de Informática Aplicada. Río Negro; ArgentinaFil: Muñoz, Horacio. Universidad Nacional de Río Negro. Laboratorio de Informática Aplicada. Río Negro; ArgentinaFil: Viadana, Alejandra. Universidad Nacional de Rosario Rosario. Facultad de Ciencia Política. Centro de investigación en Políticas Públicas y Sociedad; ArgentinaFil: Añaños, Celina. Universidad Nacional de Rosario Rosario. Facultad de Ciencia Política. Centro de investigación en Políticas Públicas y Sociedad; ArgentinaFil: Ferrero, Guillermo. Universidad Nacional de Rosario Rosario. Facultad de Ciencia Política. Centro de investigación en Políticas Públicas y Sociedad; ArgentinaA social app where local workers can build a reputation based on theirs clients califications. With a strong focus in real life interactions this platform offer a great solution to those who demand a service or product and have interest in compare local options,and also for those who offer a service and want to expand their work opportunities. Registers users can geolocate their working area and detailed their abbilities for free. This project was developed by a workteam established between the National University of Rosario (UNR) and the National University of Río Negro (UNRN). This paper presents technical details of the application and explains the context for its use, as well as associated benefits and necessary technical resources

Subtelomeric FISH analysis in 76 patients with syndromic developmental delay/intellectual disability

<p>Abstract</p> <p>Background</p> <p>Intellectual disability affects approximately 1 to 3% of the general population. The etiology is still poorly understood and it is estimated that one-half of the cases are due to genetic factors. Cryptic subtelomeric aberrations have been found in roughly 5 to 7% of all cases.</p> <p>Methods</p> <p>We performed a subtelomeric FISH analysis on 76 unrelated children with normal standard karyotype ascertained by developmental delay or intellectual disability, associated with congenital malformations, and/or facial dysmorphisms.</p> <p>Results</p> <p>Ten cryptic chromosomal anomalies have been identified in the whole cohort (13,16%), 8 in the group of patients characterized by developmental delay or intellectual disability associated with congenital malformations and facial dysmorphisms, 2 in patients with developmental delay or intellectual disability and facial dysmorphisms only.</p> <p>Conclusion</p> <p>We demonstrate that a careful clinical examination is a very useful tool for pre-selection of patients for genomic analysis, clearly enhancing the chromosomal anomaly detection rate. Clinical features of most of these patients are consistent with the corresponding emerging chromosome phenotypes, pointing out these new clinical syndromes associated with specific genomic imbalances.</p

Instrumental Monitoring of a Slow-Moving Landslide in Piedmont (Northwest Italy) for the Definition of Rainfall Thresholds

The prediction and prevention of landslide hazard is a challenging topic involving the assessment and quantitative evaluation of several elements: geological and geomorphological setting, rainfalls, and ground motion. This paper presents the multi-approach investigation of the Nevissano landslide (Asti Province, Piedmont, NW Italy). It shows a continuous and slow movement, alongside few paroxysmal events, the last recorded in 2016. The geological and geomorphological models were defined through a field survey. An inventory of the landslide’s movements and rainfall records in the period 2000–2016 was performed, respectively, through archive investigations and the application of “Moving Sum of Daily Rainfall” method, allowing for the definition of rain thresholds for the landslide activation (105 mm and 193 mm, respectively, in 3 and 30 days prior to the event). The displacements over the last 8 years (2016–2023) were monitored through an innovative in-continuum monitoring inclinometric system and Earth Observation (EO) data (i.e., relying on Interferometric Synthetic Aperture Radar, or InSAR data): it gave the opportunity to validate the rainfall thresholds previously defined. This study aims to provide information to public authorities for the appropriate management of the site. Moreover, the proposed workflow could be adopted as a guideline for investigating similar situations