33 research outputs found
As bases filosóficas e históricas do cuidado e a convocação de parceiros sexuais em HIV/aids como forma de cuidar
A provisão emergencial de médicos pelo Programa Mais Médicos e a qualidade da estrutura das unidades básicas de saúde
Contribuições epistemológicas/metodológicas para o fortalecimento de uma (cons)ciência emancipadora
Perfil epidemiológico dos usuários de um Centro de Testagem e Aconselhamento para DST/HIV da Rede Municipal de São Paulo, com sorologia positiva para o HIV
Human toxocariasis: a seroepidemiological survey in schoolchildren of Sorocaba, Brazil
Os diálogos da antropologia com a saúde: contribuições para as polÃticas públicas
Combination of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene polymorphisms as determinant risk factors for chronic allograft dysfunction
Objective. The aim of this study was to investigate the frequency of gene angiotensincoVerting enzyme insertion/deletion (ACE I/D) and methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) variants, as well as to evaluate the plasma homocysteine concentrations in 217 patients who underwent renal transplantation at least 12 months prior to define risk factors for chronic allograft dysfunction. Methods. The presence of the polymorphism ACE deletion was assessed by polymerase chain reaction (PCR) analysis. MTHFR polymorphisms were determined by PCR and restriction fragment length polymorphism (RFPL) techniques. The restriction enzymes were Hinf I and Mbo II for MTHFR variants C677T and A1298C, respectively. Plasma homocysteine concentrations were measured by liquid chromatography-tandem mass spectrometry (LS-MS/MS). Results. Hyperhomocysteinernias were more common in patients with chronic allograft dysfunction (P =.004). No statistically significant differences were observed between the allelic and genotypic distributions of MTHFR and ACE polymorphisms. An effective risk factor was found when the polymorphisms of the ACE and MTHFR genes and hyperhomocysteinemia were associated (odds ratio 2.51; 95% confidence interval 1.19-5.28). In conclusion, our study identified that the presence of hyperhomocysteinernia in combination with unfavorable genotypes contributes to an increased risk for development of chronic allograft dysfunction.391788
Alta prevalência de usuários que não retornam ao centro de testagem e aconselhamento (CTA) para o conhecimento do seu status sorológico - Rio Grande, RS, Brasil
The Testing and Counseling Centers are important sources of epidemiological information. This study describes a research conducted with the users of the Testing and Counseling Center of Rio Grande-RS submitted to anti-HIV test during the period 2001-2004. Demographic and behavioral factors of individuals attended in the service were analyzed using the database SISCTA- 2002/RG. HIV-1 seropositivity between 2001 and 2004 was of 1,1%; 2,4%; 2,3% and 1,7%, respectively. In 2003 and 2004, 37,7% and 36% of the HIV-1 positive patients did not return to the Testing and Counseling Center for getting the result of their serological anti-HIV or confirmatory tests. These results seem to reflect some tendencies of the HIV epidemic in Rio Grande and in Brazil. It is important to emphasize the high percentage of HIV-1 positive patients who do not return for getting the result of their test. In terms of public health this risk behavior may jeopardize the efforts for controlling the epidemic.Os Centros de Testagem e Aconselhamento (CTA) constituem importantes fontes de informações epidemiológicas, que quando bem gerenciadas e atualizadas, permitem o conhecimento e a análise das caracterÃsticas da população atendida por esses serviços. Esse estudo descreve o perfil dos usuários do CTA de Rio Grande (RS) que foram submetidos à sorologia anti-HIV entre os anos de 2001 e 2004. Variáveis demográficas relativas ao comportamento e práticas daspessoas que procuraram o serviço foram analisadas, mediante consulta ao banco de dados SISCTA- 2002/RG. A soropositividade para HIV-1 foi de 1,1%; 2,4%; 2,3% e 1,7% de 2001 a 2004, respectivamente. Nos anos de 2003 e 2004, 37,7% e 36%, respectivamente, dos pacientes HIV-1+ não retornaram ao CTA para conhecimento dos exames anti-HIV ou confirmatório. Os resultados analisados parecem refletir algumas tendências da epidemia em Rio Grande e no paÃs. É importanteressaltar a alta porcentagem de pacientes HIV-1 positivos que não procuram o resultado do seu teste. Em termos de saúde pública essa situação pode colocar em risco os esforços para o controle da epidemia
Effect of folate, vitamin B-6, and vitamin B-12 intake and MTHFR C677T polymorphism on homocysteine concentrations of renal transplant recipients
Plasma hyperhomocysteinemia (HHcy) is considered a risk factor for chronic allograft dysfunction (CAD), the main cause of functional loss in transplant recipients. Genetic polymorphisms that alter enzymes involved in homocysteine (Hcy) metabolism, such as methylenetetrahydrofolate reductase (MTHFR), and vitamin deficiency can result in HHcy. The objectives of this study were to investigate the relationship between HHcy and CAD development, and to evaluate the effect of intake of folate and vitamins B-6 and 13,2 as well as MTHFR C677T polymorphism on Hcy concentrations. Ninety-eight renal transplant recipients including 48 showing CAD and 50 with normal renal function (NRF), were included in this cross-sectional study. Peripheral blood samples were collected for plasma Hcy quantification by liquid chromatography/sequential mass spectrometry (LC-MS/MS), and for MTHFR polymorphism analysis using polymerase chain reaction-restriction fragment length polymorphism. Dietary intake was evaluated using a nutritional questionnaire. HHcy (P =.002) and higher mean concentrations of Hcy (P =.029) were associated with CAD. An association was observed between HHcy and 677T variant allele in the CAD group (P =.0005). There was no correlation between Hcy concentration and folate, vitamin B-6 or vitamin B-12 intake in the CAD group. However, a negative correlation was observed between Hcy concentration and folate intake (P =.043), and also between Hcy concentration and vitamin 136 intake (P =.030) in the NRF group. According to our study, HHcy is associated with CAD development. In patients with CAD, MTHFR polymorphism seems to have a greater effect on the Hey concentration than the vitamin intake. Increased folate and vitamin B, intakes seem to reduce Hcy concentrations among transplant recipients with NRF, and could contribute to reducing the risk of CAD development.39103163316