I sistemi di Business Intelligence e il coordinamento organizzativo.

Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca.Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca.LUISS PhD Thesi

I sistemi di Business Intelligence e il coordinamento organizzativo.

Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca

Caduta accidentale di una paziente sottoposta a riduzione chirurgica di frattura di femore: analisi delle cause profonde

Introduction. Inpatient falls in hospital is a relevant problem. The first essential step is to know the risks to prevent them, through reactive or proactive analysis. In this study we used the Root Causes Analysis (RCA) to analyze an accidental fall of a 79-year-old patient after a surgical intervention for a femoral fracture. The aim of the analysis is to evaluate the effect of this method on sanitary professionals. Material and methods. The study was conducted at the Operative Unity of Orthopaedics and Traumatology, “Beato Matteo Institute”, Vigevano. RCA was realised in the following steps: creation of the team, individuation of the causes, collection and evaluation of the information, identification of the solutions and the proposals of improvement. Results. The RCA showed the following causes: incomplete assessment of the patient, lacking professional skills, lacking of procedures and safety systems, risk factors connected both to the patient and the environment. The improvement proposals were: education and information of professionals, education of patient and caregivers, nursing interventions, environmental strategies and signalling systems. Discussion. RCA is an useful tool for risk management and it allowed to highlight causes and corrective actions of the accidental fall. Furthermore, this case allowed to underline advantages and disadvantages of this method. Advantages were the involvement of different professionals and sharing of objectives of systems improvement; the importance of the introduction of new instruments for risks identification and specific education to use them. Among the disadvantages we can list: difficulties in finding all the informations to correctly analyse the case, perception of too much bureaucracy in the procedure, and fear of a “punitive” use of the information collected

Modelling shortwave and longwave downward radiation and air temperature driving ablation at the Forni Glacier (Stelvio National Park, Italy)

We focus here on modelling the meteorological parameters most influencing snow/ice melting over an alpine glacier. Specifically, we consider shortwave and longwave downward radiation, and air temperature. We set up and test a methodology for their accurate distribution at the glacier surface, which can be applied whenever: i) supraglacial meteoro-logical measurements are available or ii) weather data are acquired from a station quite close to the glacier. As a suitable site to test our approach we selected the Forni Glacier, in the Italian Alps, where an Automatic Weather Station (AWS) has been running since autumn 2005 thus giving a robust dataset for developing a field based modeling approach. First, we modelled and distributed the incoming solar radiation by taking into account actual atmospheric conditions, glacier topography and shading. Then, we modelled the incoming longwave radiation considering cloud-cover and air temperature. Third, we investigated a local lapse rate to depict the yearly variability of the vertical air temperature gradient, to assess the actual thermal conditions at different elevations. Finally, we compared the modeled values against data collected on the field. The results display that during the glacier ablation period (i.e.: May-September): i) our approach provides a good depiction of both point incoming solar and infrared radiation fluxes, ii) the spatial distribution of the incoming solar radiation we developed is satisfactory, iii) our tests suggest that the incoming longwave fluxes can be considered constant over the whole glacier ablation area thus neglecting its spatial distribution, and iv) the application of a local lapse rate provides a good distribution of air temperature at the glacier surface

Lotus Birth Associated With Idiopathic Neonatal Hepatitis

In the present case, the infant presented with a complication of LB. There was a close temporal relationship between LB and the onset of clinical symptoms. The baby had persistent jaundice associated with a severe increase in aspartate and alanine aminotransferases without evidence of cholestasis. Recovery occurred spontaneously after the first months of life. Hepatobiliary, hematological, metabolic, endocrine, and genetic disorders were ruled out

The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the HS2 enhancer of the GATA1 gene in protecting the expression of a β-globin minigene delivered by a lentiviral vector in hematopoietic stem/progenitor cells. Gene expression from proviruses carrying GATA1-HS2 in both LTRs was persistent and resistant to silencing at most integration sites in the in vivo progeny of human hematopoietic progenitors and murine long-term repopulating stem cells. The GATA1-HS2-modified vector allowed correction of murine β-thalassemia at low copy number without inducing clonal selection of erythroblastic progenitors. Chromatin immunoprecipitation studies showed that GATA1 and the CBP acetyltransferase bind to GATA1-HS2, significantly increasing CBP-specific histone acetylations at the LTRs and β-globin promoter. Recruitment of CBP by the LTRs thus establishes an open chromatin domain encompassing the entire provirus, and increases the therapeutic efficacy of β-globin gene transfer by reducing expression variegation and epigenetic silencing

Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome

Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation. About 90% of SMS cases are due to a 17p11.2 deletion containing retinoic acid induced1 (RAI1) gene, 10% are due to heterozygousmutations affecting RAI1 coding region. Little is known about RAI1 role

an efficient context free parser for augmented phrase structure grammars

In this paper we present an efficient context-free (CF) bottom-up, non deterministic parser. It is an extension of the ICA (Immediate Constituent Analysis) parser proposed by Grishman (1976), and its major improvements are described.It has been designed to run Augmented Phrase-Structure Grammars (APSG) and performs semantic interpretation in parallel with syntactic analysis.It has been implemented in Franz Lisp and runs on VAX 11/780 and, recently, also on a SUN workstation, as the main component of a transportable Natural Language Interface (SAIL = Sistema per l'Analisi e l'Interpretazione del Linguaggio). Subsets of grammars of italian written in different formalisms and for different applications have been experimented with SAIL. In particular, a toy application has been developed in which SAIL has been used as interface to build a knowledge base in MRS (Genesereth et al. 1980, Genesereth 1981) about ski paths in a ski environment, and to ask for advice about the best touristic path under specific weather and physical conditions

The use of non-invasive ventilation to treat acute respiratory failure in long term care setting: clinical experience in elderly patient

Background. Nowadays older patients with acute respiratory failure (ARF) leading to a severe respiratory acidosis are frequently ventilated using a non-invasive approach in intensive care unit (ICU). Current guidelines suggest that patients with more severe acidosis should be managed in a higher dependency area. However, the use of non-invasive ventilation (NIV) is effective and safe in treating ARF in general wards in elderly. Case report. a 82 years old male patient was admitted to a long term care facility due to a severe chronic obstructive pulmonary disease (COPD). Three days after the admission, he suffered of severe acute exacerbation of COPD leading to hypercapnic coma. NIV in Bi-PAP mode and standard medical therapy was started, taking into consideration the do-not-intubate order of the patient. His state of consciousness improved after 48 hours of NIV with decreasing of PaCO2 values and the patient was progressively weaned from the ventilator. Conclusions. NIV should be considered a successful approach even in unusual setting of long term facility. The choice of use NIV should be taken by multidisciplinary medical staff in a setting where nurses and medical team are trained in NIV protocol, in order to reduce ICU admission, intubation rates and mortality