Modelling of Tirapazamine effects on solid tumour morphology

Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive drugs, Tirapazamine (TPZ) which is in clinical trials I and II. We calculated solid tumour mass in our previous work and then integrated that model with TPZ infusion. We calculated TPZ cytotoxicity, concentration, penetra-tion with increasing distance from blood vessel and offered resistance from micro-environments for drug penetration inside the tumour while considering each cell as an individual entity. The impact of these factors on tumour morphology is also showed to see the drug behaviour inside animals/humans tumours. We maintained the heterogeneity factors in presented model as observed in real tumour mass es-pecially in terms of cells proliferation, cell movement, extracellular matrix (ECM) interaction, and the gradients of partial oxygen pressure (pO2) inside tumour cells during the whole growth and treatment activity. The results suggest that TPZ high concentration in combination with chemotherapy should be given to get maximum abnormal cell killing. This model can be a good choice for oncologists and re-searchers to explore more about TPZ action inside solid tumour

Gauge vs. Gravity mediation in models with anomalous U(1)'s

In an attempt to implement gauge mediation in string theory, we study string effective supergravity models of supersymmetry breaking, containing anomalous gauge factors. We discuss subtleties related to gauge invariance and the stabilization of the Green-Schwarz moduli, which set non-trivial constraints on the transmission of supersymmetry breaking to MSSM via gauge interactions. Given those constraints, it is difficult to obtain the dominance of gauge mediation over gravity mediation. Furthermore, generically the gauge contributions to soft terms contain additional non-standard terms coming from D-term contributions. Motivated by this, we study the phenomenology of recently proposed hybrid models, where gravity and gauge mediations compete at the GUT scale, and show that such a scenario can respect WMAP constraints and would be easily testable at LHC.Comment: 40 pages, 5 figure

N=1/2 quiver gauge theories from open strings with R-R fluxes

We consider a four dimensional N=1 gauge theory with bifundamental matter and a superpotential, defined on stacks of fractional branes. By turning on a flux for the R-R graviphoton field strength and computing open string amplitudes with insertions of R-R closed string vertices, we introduce a non-anticommutative deformation and obtain the N=1/2 version of the theory. We also comment on the appearance of a new structure in the effective Lagrangian.Comment: 30 pages, 5 figures, JHEP class (included); some comments and a reference adde

Immunosenescence (iSenescence) correlates with progression (PD) to PD-(L)1 inhibitors (IO) and not to platinum-chemotherapy (PCT) in advanced non-small cell lung cancer (aNSCLC) patients (pts)

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Membrane Instantons and de Sitter Vacua

We investigate membrane instanton effects in type IIA strings compactified on rigid Calabi-Yau manifolds. These effects contribute to the low-energy effective action of the universal hypermultiplet. In the absence of additional fivebrane instantons, the quaternionic geometry of this hypermultiplet is determined by solutions of the three-dimensional Toda equation. We construct solutions describing membrane instantons, and find perfect agreement with the string theory prediction. In the context of flux compactifications we discuss how membrane instantons contribute to the scalar potential and the stabilization of moduli. Finally, we demonstrate the existence of meta-stable de Sitter vacua.Comment: v3: minor clarifications, JHEP version, 38 page

Spin - or, actually: Spin and Quantum Statistics

The history of the discovery of electron spin and the Pauli principle and the mathematics of spin and quantum statistics are reviewed. Pauli's theory of the spinning electron and some of its many applications in mathematics and physics are considered in more detail. The role of the fact that the tree-level gyromagnetic factor of the electron has the value g = 2 in an analysis of stability (and instability) of matter in arbitrary external magnetic fields is highlighted. Radiative corrections and precision measurements of g are reviewed. The general connection between spin and statistics, the CPT theorem and the theory of braid statistics are described.Comment: 50 pages, no figures, seminar on "spin