44 research outputs found
Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women
OBJECTIVE—Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women
Selective Adsorption of Homocysteine Using an HFR-ON LINE Technique
HFR-ON LINE (double chamber HDF with
reinfusion of ultrafiltrate regenerated through a charcoalresin cartridge) is a novel method which combines the processes of diffusion, convection, and adsorbance. We have investigated the effect of such a treatment on the
homocysteine (Hcy) levels in ten patients with a mean Hcy level of 57.6 mmol/L (range 24.1–119.7 mmol/L). We
have measured the Hcy, folate, and vitamin B12 predialysis and postdialysis, and in the ultrafiltrate precartridge and postcartridge at 10, 120, and 240 min. The mean Hcy
levels were 57.6 and 35.3 mmol/L (range 9.9–80.3 mmol/L) (P = 0.005) predialysis and postdialysis, respectively, while folate and vitamin B12 were unchanged. Precartridge
and postcartridge Hcy levels were 11.6 vs. 2.5 mmol/L (P = 0.005), 9.3 vs. 3.9 mmol/L (P = 0.005), and 7.7 vs.
4.6 mmol/L (P = 0.012) at the three time points considered, while folate and vitamin B12 were essentially
undetectable.These preliminary data, which need confirmation
in a long-term study, seem to indicate that HFRONLINE is able to reduce Hcy levels not only through a likely reduction of uremic toxins, but also through an actual removal of Hcy by adsorbance onto the charcoalresin
cartridge