El conflicto del Tirol meridional

Hasta hace muy pocos años ha existido el conflicto internacional entre Austria e Italia sobre El Tirol meridional que ocasiono gravísimas tensiones pero que entre tanto puede decirse que esta superado constituyendo uno de los pocos puntos positivos de la convivencia internacional de la Europa de postguerra. Solo por este hecho justificaría ya el estudio del problema y de sus soluciones. Se analizan las posturas del partido socialista y del populista austríacos ante el conflicto bilateral la postura de Italia y Austria al llevarlo ante la ONU y se sintetiza por periodos los pasos dados para solucionarlo definitivamente modificando el primer estatuto de autonomía administrativa. El capitulo XII contiene las conclusiones y es donde se sostienen algunas tesis

Controlled composite processing based on off-stoichiometric thiol-epoxy dual-curing systems with sequential heat release (SHR)

Control of curing rate and exothermicity during processing of thermosetting composite materials is essential in order to minimize the formation of internal stresses leading to mechanical and dimensional defects in the samples, especially in thick composite samples. It was recently proposed that sequential heat release, an approach based on the kinetic control of the curing sequence of dual-curing thermosets, would enable a step-wise release of the reaction heat and therefore a better control of conversion and temperature profiles during the crosslinking stage. In this article, it is shown experimental proof of this concept obtained by means of an instrumented mold that can be used for the processing of small samples with and without carbon fiber reinforcement. Safe processing scenarios have been defined by numerical simulation using a simplified two-dimensional heat transfer model and validated experimentally.Peer ReviewedPostprint (author's final draft

PMut2: a web-based tool for predicting pathological mutations on proteins

Amino acid substitutions in proteins can result in an altered phenotype which might lead to a disease. PMut2 is a method that can predict whether a mutation has a pathological effect on the protein function. It uses current machine learning algorithms based on protein sequence derived information. The accuracy of PMut2 is as high as 82%, with a Matthews correlation coefficient of 0,62. PMut2 predictions can be obtained through a modern website which also allows to apply the same machine learning methodology that is used to train PMut2 to custom training sets, allowing users to build their own tailor-made predictors

Multivariable controller design for the cooling system of a PEM fuel cell by considering nearly optimal solutions in a multi-objective optimization approach

[EN] This paper presents a design for the multivariable control of a cooling system in a PEM (proton exchange membrane) fuel cell stack. This system is complex and challenging enough: interactions between variables, highly nonlinear dynamic behavior, etc. This design is carried out using a multiobjective optimization methodology. There are few previous works that address this problem using multiobjective techniques. Also, this work has, as a novelty, the consideration of, in addition to the optimal controllers, the nearly optimal controllers nondominated in their neighborhood (potentially useful alternatives). In the multiobjective optimization problem approach, the designer must make decisions that include design objectives; parameters of the controllers to be estimated; and the conditions and characteristics of the simulation of the system. However, to simplify the optimization and decision stages, the designer does not include all the desired scenarios in the multiobjective problem definition. Nevertheless, these aspects can be analyzed in the decision stage only for the controllers obtained with a much less computational cost. At this stage, the potentially useful alternatives can play an important role. These controllers have significantly different parameters and therefore allow the designer to make a final decision with additional valuable information. Nearly optimal controllers can obtain an improvement in some aspects not included in the multiobjective optimization problem. For example, in this paper, various aspects are analyzed regarding potentially useful solutions, such as (1) the influence of certain parameters of the simulator; (2) the sample time of the controller; (3) the effect of stack degradation; and (4) the robustness. Therefore, this paper highlights the relevance of this in-depth analysis using the methodology proposed in the design of the multivariable control of the cooling system of a PEM fuel cell. This analysis can modify the final choice of the designer.This study was supported in part by the Ministerio de Ciencia, Innovacion y Universidades (Spain) (grant no. RTI2018-096904-B-I00) and by the Generalitat Valenciana regional government through project AICO/2019/055.Pajares-Ferrando, A.; Blasco, X.; Herrero Durá, JM.; Simarro Fernández, R. (2020). Multivariable controller design for the cooling system of a PEM fuel cell by considering nearly optimal solutions in a multi-objective optimization approach. Complexity. 2020:1-17. https://doi.org/10.1155/2020/8649428S1172020Gunantara, N. (2018). A review of multi-objective optimization: Methods and its applications. Cogent Engineering, 5(1), 1502242. doi:10.1080/23311916.2018.1502242Engau, A., & Wiecek, M. M. (2007). Generating ε-efficient solutions in multiobjective programming. European Journal of Operational Research, 177(3), 1566-1579. doi:10.1016/j.ejor.2005.10.023Loridan, P. (1984). ?-solutions in vector minimization problems. Journal of Optimization Theory and Applications, 43(2), 265-276. doi:10.1007/bf00936165White, D. J. (1986). Epsilon efficiency. Journal of Optimization Theory and Applications, 49(2), 319-337. doi:10.1007/bf00940762Pajares, A., Blasco, X., Herrero, J. M., & Reynoso-Meza, G. (2018). A Multiobjective Genetic Algorithm for the Localization of Optimal and Nearly Optimal Solutions Which Are Potentially Useful: nevMOGA. Complexity, 2018, 1-22. doi:10.1155/2018/1792420Schutze, O., Vasile, M., & Coello, C. A. C. (2011). Computing the Set of Epsilon-Efficient Solutions in Multiobjective Space Mission Design. Journal of Aerospace Computing, Information, and Communication, 8(3), 53-70. doi:10.2514/1.46478Pajares, A., Blasco, X., Herrero, J. M., & Reynoso-Meza, G. (2019). A New Point of View in Multivariable Controller Tuning Under Multiobjective Optimization by Considering Nearly Optimal Solutions. IEEE Access, 7, 66435-66452. doi:10.1109/access.2019.2915556Fredriksson, A., Forsgren, A., & Hårdemark, B. (2011). Minimax optimization for handling range and setup uncertainties in proton therapy. Medical Physics, 38(3), 1672-1684. doi:10.1118/1.3556559Lee, J., & Johnson, G. E. (1993). Optimal tolerance allotment using a genetic algorithm and truncated Monte Carlo simulation. Computer-Aided Design, 25(9), 601-611. doi:10.1016/0010-4485(93)90075-yAndújar, J. M., & Segura, F. (2009). Fuel cells: History and updating. A walk along two centuries. Renewable and Sustainable Energy Reviews, 13(9), 2309-2322. doi:10.1016/j.rser.2009.03.015Mehta, V., & Cooper, J. S. (2003). Review and analysis of PEM fuel cell design and manufacturing. Journal of Power Sources, 114(1), 32-53. doi:10.1016/s0378-7753(02)00542-6De las Heras, A., Vivas, F. J., Segura, F., Redondo, M. J., & Andújar, J. M. (2018). Air-cooled fuel cells: Keys to design and build the oxidant/cooling system. Renewable Energy, 125, 1-20. doi:10.1016/j.renene.2018.02.077Kandlikar, S. G., & Lu, Z. (2009). Thermal management issues in a PEMFC stack – A brief review of current status. Applied Thermal Engineering, 29(7), 1276-1280. doi:10.1016/j.applthermaleng.2008.05.009Yan, Q., Toghiani, H., & Causey, H. (2006). Steady state and dynamic performance of proton exchange membrane fuel cells (PEMFCs) under various operating conditions and load changes. Journal of Power Sources, 161(1), 492-502. doi:10.1016/j.jpowsour.2006.03.077Maghanki, M. M., Ghobadian, B., Najafi, G., & Galogah, R. J. (2013). Micro combined heat and power (MCHP) technologies and applications. Renewable and Sustainable Energy Reviews, 28, 510-524. doi:10.1016/j.rser.2013.07.053Notter, D. A., Kouravelou, K., Karachalios, T., Daletou, M. K., & Haberland, N. T. (2015). Life cycle assessment of PEM FC applications: electric mobility and μ-CHP. Energy & Environmental Science, 8(7), 1969-1985. doi:10.1039/c5ee01082aMartinez, S., Michaux, G., Salagnac, P., & Bouvier, J.-L. (2017). Micro-combined heat and power systems (micro-CHP) based on renewable energy sources. Energy Conversion and Management, 154, 262-285. doi:10.1016/j.enconman.2017.10.035Elmer, T., Worall, M., Wu, S., & Riffat, S. B. (2015). Fuel cell technology for domestic built environment applications: State of-the-art review. Renewable and Sustainable Energy Reviews, 42, 913-931. doi:10.1016/j.rser.2014.10.080Hawkes, A., Staffell, I., Brett, D., & Brandon, N. (2009). Fuel cells for micro-combined heat and power generation. Energy & Environmental Science, 2(7), 729. doi:10.1039/b902222hEllamla, H. R., Staffell, I., Bujlo, P., Pollet, B. G., & Pasupathi, S. (2015). Current status of fuel cell based combined heat and power systems for residential sector. Journal of Power Sources, 293, 312-328. doi:10.1016/j.jpowsour.2015.05.050Strahl, S., & Costa-Castelló, R. (2017). Temperature control of open-cathode PEM fuel cells. IFAC-PapersOnLine, 50(1), 11088-11093. doi:10.1016/j.ifacol.2017.08.2492Zhang, G., & Kandlikar, S. G. (2012). A critical review of cooling techniques in proton exchange membrane fuel cell stacks. International Journal of Hydrogen Energy, 37(3), 2412-2429. doi:10.1016/j.ijhydene.2011.11.010Navarro Gimenez, S., Herrero Dura, J. M., Blasco Ferragud, F. X., & Simarro Fernandez, R. (2019). Control-Oriented Modeling of the Cooling Process of a PEMFC-Based $\mu$ -CHP System. IEEE Access, 7, 95620-95642. doi:10.1109/access.2019.2928632Herrero, J. M., García-Nieto, S., Blasco, X., Romero-García, V., Sánchez-Pérez, J. V., & Garcia-Raffi, L. M. (2008). Optimization of sonic crystal attenuation properties by ev-MOGA multiobjective evolutionary algorithm. Structural and Multidisciplinary Optimization, 39(2), 203-215. doi:10.1007/s00158-008-0323-7Bristol, E. (1966). On a new measure of interaction for multivariable process control. IEEE Transactions on Automatic Control, 11(1), 133-134. doi:10.1109/tac.1966.1098266Blasco, X., Herrero, J. M., Sanchis, J., & Martínez, M. (2008). A new graphical visualization of n-dimensional Pareto front for decision-making in multiobjective optimization. Information Sciences, 178(20), 3908-3924. doi:10.1016/j.ins.2008.06.010Schmittinger, W., & Vahidi, A. (2008). A review of the main parameters influencing long-term performance and durability of PEM fuel cells. Journal of Power Sources, 180(1), 1-14. doi:10.1016/j.jpowsour.2008.01.07

Web-based tool for the annotation of pathological variants on proteins: PMut 2017 update

Assessing the impact of amino acid mutations in human health is an important challenge in biomedical research. As sequencing technologies are more available, and more individual genomes become accessible, the number of identified variants has dramatically increased. PMut, released back in 2005 [1], has been one of the popular predictors in this field. PMut was a neural-network-based classifier using sequence data to provide a pathology score for point mutations in proteins. We now release a new, revised, and much more powerful version of PMut. It features PyMut prediction engine, a Python module that includes numerous machine learning capabilities aimed at the analysis of protein variant pathology annotation. We also release PMut2017 predictor, a full update of the PMut predictor based on the SwissVar [2] variation database. It achieves an accuracy of 82% and a Matthews Correlation Coefficient (MCC) of 0.62, and matches the most popular predictors’ performance. The engine is implemented in Python using MongoDB engine for data management. It has been adapted to run at the HPC level to cover large scale annotation projects

A Comparison of Archiving Strategies for Characterization of Nearly Optimal Solutions under Multi-Objective Optimization

[EN] In a multi-objective optimization problem, in addition to optimal solutions, multimodal and/or nearly optimal alternatives can also provide additional useful information for the decision maker. However, obtaining all nearly optimal solutions entails an excessive number of alternatives. Therefore, to consider the nearly optimal solutions, it is convenient to obtain a reduced set, putting the focus on the potentially useful alternatives. These solutions are the alternatives that are close to the optimal solutions in objective space, but which differ significantly in the decision space. To characterize this set, it is essential to simultaneously analyze the decision and objective spaces. One of the crucial points in an evolutionary multi-objective optimization algorithm is the archiving strategy. This is in charge of keeping the solution set, called the archive, updated during the optimization process. The motivation of this work is to analyze the three existing archiving strategies proposed in the literature (ArchiveUpdateP(Q,epsilon)D(xy), Archive_nevMOGA, and targetSelect) that aim to characterize the potentially useful solutions. The archivers are evaluated on two benchmarks and in a real engineering example. The contribution clearly shows the main differences between the three archivers. This analysis is useful for the design of evolutionary algorithms that consider nearly optimal solutions.This work was supported in part by the Ministerio de Ciencia, Innovacion y Universidades (Spain) (grant number RTI2018-096904-B-I00), by the Generalitat Valenciana regional government through project AICO/2019/055 and by the Universitat Politecnica de Valencia (grant number SP20200109).Pajares-Ferrando, A.; Blasco, X.; Herrero Durá, JM.; Martínez Iranzo, MA. (2021). A Comparison of Archiving Strategies for Characterization of Nearly Optimal Solutions under Multi-Objective Optimization. Mathematics. 9(9):1-28. https://doi.org/10.3390/math9090999S1289

Analyzing the Nearly Optimal Solutions in a Multi-Objective Optimization Approach for the Multivariable Nonlinear Identification of a PEM Fuel Cell Cooling System

[EN] In this work, the parametric identification of a cooling system in a PEM (proton exchange membrane) fuel cell is carried out. This system is multivariable and nonlinear. In this type of system there are different objectives and the unmodeled dynamics cause conflicting objectives (prediction errors in each output). For this reason, resolution is proposed using a multi-objective optimization approach. Nearly optimal alternatives can exist in any optimization problem. Among them, the nearly optimal solutions that are significantly different (that we call nearly optimal solutions nondominated in their neighborhood) are potentially useful solutions. In identification problems, two situations arise for consideration: 1) aggregation in the design objectives (when considering the prediction error throughout the identification test). When an aggregation occurs in the design objectives, interesting non-neighboring (significantly different) multimodal and nearly optimal alternatives appear. These alternatives have different trade-offs in the aggregated objectives; 2) new objectives in decision making appear. Some models can, with similar performance in the design objectives, obtain a significant improvement in new objectives not included in the optimization phase. A typical case of additional objectives are the validation objectives. In these situations, nearly optimal solutions nondominated in their neighborhood play a key role. These alternatives allow the designer to make the final decision with more valuable information. Therefore, this work highlights, as a novelty, the relevance of considering nearly optimal models nondominated in their neighborhood in problems of parametric identification of multivariable nonlinear systems and shows an application in a complex problem.This work was supported in part by the Ministerio de Ciencia, Innovacion y Universidades, Spain, under Grant RTI2018-096904-B-I00, and in part by the Generalitat Valenciana Regional Government under Project AICO/2019/055.Pajares-Ferrando, A.; Blasco, X.; Herrero Durá, JM.; Salcedo-Romero-De-Ávila, J. (2020). Analyzing the Nearly Optimal Solutions in a Multi-Objective Optimization Approach for the Multivariable Nonlinear Identification of a PEM Fuel Cell Cooling System. IEEE Access. 8:114361-114377. https://doi.org/10.1109/ACCESS.2020.3003741S114361114377

New epoxy thermosets derived from clove oil prepared by epoxy-amine curing

New thermosets from a triglycidyl eugenol derivative (3EPOEU) as a renewable epoxy monomer were obtained by an epoxy-amine curing process. A commercially-available Jeffamine® and isophorone diamine, both obtained from renewable resources, were used as crosslinking agents, and the materials obtained were compared with those obtained from a standard diglycidylether of bisphenol A (DGEBA). The evolution of the curing process was studied by differential scanning calorimetry and the materials obtained were characterized by means of calorimetry, thermogravimetry, thermodynamomechanical analysis, stress–strain tests and microindentation. 3EPOEU formulations were slightly less reactive, and the thermosets obtained showed higher Tgs than those prepared from DGEBA, since they had higher crosslinking density than formulations with DGEBA because of the more compact structure and higher functionality of the eugenol derivative. 3EPOEU thermosets showed good thermal stability and mechanical properties. The results obtained in this study allow us to conclude that the triglycidyl derivative of eugenol, 3EPOEU, is a safe and environmentally friendly alternative to DGEBA.Postprint (published version