GNSS contribution to monitor severe rainfalls: an innovative procedure for wide and orographically complex area with existing infrastructures

The paper presents an innovative methodology for monitoring the content of Precipitable Water Vapour (PWV) in atmosphere for wide and orographically complex area. The water vapour content is strictly related to the occurrence of rains, hence the knowledge of PWV can be useful to interpret and monitor severe meteorological events. An automatic procedure has been conceived for producing 2D PWV maps with high spatial and temporal resolution starting from Zenith Tropospheric Delay (ZTD) estimations, obtained from GNSS Permanent Stations (PSs) network compensation, and from Pressure (P) and Temperature (T) observations, all collected by existing infrastructures. In the present work both a 1D approach to analyse ZTD and PWV time series and a 2D approach to localize severe meteorological events in time and space are presented. The procedure is then applied to a wide and orographically complex area, to study two severe meteorological events occurred in Genoa with reliable results. The introduction of the Heterogeneity Index (HI), accounting the spatial variability of PWV, allows to individuate the correct timing and location of severe meteorological events

Innovations in geomatics teaching during the COVID-19 emergency

The approach in the teaching process is changing, thanks to the increased awareness that a higher students\u2019 involvement leads to a better quality of their learning. The aim is to make the students more participative, avoiding a unidirectional lesson and encouraging their wish to keep updated on the course advancements. However, innovative teaching methodologies are not yet widespread, mainly in STEM (Science, Technology, Engineering, and Mathematics) disciplines. At the University of Genoa, the experimentation of innovative teaching techniques has been significant and worthy especially because it was planned before the COVID-19 emergency and applied in the scenario of forced remote teaching. Thanks to the introduc- tion of novel technological instruments, several techniques have been exploited to realize interactive lessons and promoting students\u2019 involvement. The present work discloses the employed techniques and frames them within the state of the art of innovative teaching, highlighting their contribution in the teaching activities related to the Geomatics field of knowledge. The acquired experiences in Geomatics dissemination and a critical analysis, including teachers\u2019 and students\u2019 perception about the tested innovative teaching/learning tools, are also reported. In general, the innovations introduced in teaching and learning processes during the COVID-19 sanitary emergency were warmly received by the entire community, including teachers, students, and teaching assistants

Deriving Coastal Shallow Bathymetry from Sentinel 2-, Aircraft- and UAV-Derived Orthophotos: A Case Study in Ligurian Marinas

Bathymetric surveys of shallow waters are increasingly necessary for navigational safety and environmental studies. In situ surveys with floating acoustic sensors allow the collection of high-accuracy bathymetric data. However, such surveys are often unfeasible in very shallow waters in addition to being expensive and requiring specific sectorial skills for the acquisition and processing of raw data. The increasing availability of optical images from Uncrewed Aerial Vehicles, aircrafts and satellites allows for bathymetric reconstruction from images thanks to the application of state-of-the-art algorithms. In this paper, we illustrate a bathymetric reconstruction procedure involving the classification of the seabed, the calibration of the algorithm for each class and the subsequent validation. We applied this procedure to high-resolution, UAV-derived orthophotos, aircraft orthophotos and Sentinel-2 Level-2A images of two marinas along the western Ligurian coastline in the Mediterranean Sea and validated the results with bathymetric data derived from echo-sounder surveys. Our findings showed that the aircraft-derived bathymetry is generally more accurate than the UAV-derived and Sentinel-2 bathymetry in all analyzed scenarios due to the smooth color of the aircraft orthophotos and their ability to reproduce the seafloor with a considerable level of detail

FOSS tools and applications for education in geospatial sciences

While the theory and implementation of geographic information systems (GIS) have a history of more than 50 years, the development of dedicated educational tools and applications in this field is more recent. This paper presents a free and open source software (FOSS) approach for education in the geospatial disciplines, which has been used over the last 20 years at two Italian universities. The motivations behind the choice of FOSS are discussed with respect to software availability and development, as well as educational material licensing. Following this philosophy, a wide range of educational tools have been developed, covering topics from numerical cartography and GIS principles to the specifics regarding different systems for the management and analysis of spatial data. Various courses have been implemented for diverse recipients, ranging from professional training workshops to PhD courses. Feedback from the students of those courses provides an invaluable assessment of the effectiveness of the approach, supplying at the same time directions for further improvement. Finally, lessons learned after 20 years are discussed, highlighting how the management of educational materials can be difficult even with a very open approach to licensing. Overall, the use of free and open source software for geospatial (FOSS4G) science provides a clear advantage over other approaches, not only simplifying software and data management, but also ensuring that all of the information related to system design and implementation is available

Innovative In Vitro Strategy for Assessing Aluminum Bioavailability in Oral Care Cosmetics

Aluminum is an element found in nature and in cosmetic products. It can interfere with the metabolism of other cations, thus inducing gastrointestinal disorder. In cosmetics, aluminum is used in antiperspirants, lipsticks, and toothpastes. The aim of this work is to investigate aluminum bioavailability after accidental oral ingestion derived from the use of a toothpaste containing a greater amount of aluminum hydroxide than advised by the Scientific Committee on Consumer Safety (SCCS). To simulate in vitro toothpaste accidental ingestion, the INFOGEST model was employed, and the amount of aluminum was measured through the ICP-AES analysis. Tissue barrier integrity was analyzed by measuring transepithelial electric resistance, and the tissue architecture was checked through light microscopy. The margin of safety was also calculated. Overall, our results indicate that the acute exposure to aluminum accidentally ingested from toothpastes is safe for the final user, even in amounts higher than SCCS indications

An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology

Polyphenolic compounds constitute a diverse group of natural components commonly occurring in various plant species, known for their potential to exert both beneficial and detrimental effects. Additionally, these polyphenols have also been implicated as endocrine-disrupting (ED) chemicals, raising concerns about their widespread use in the cosmetics industry. In this comprehensive review, we focus on the body of literature pertaining to the estrogenic properties of ED chemicals, with a particular emphasis on the interaction of isoflavones with estrogen receptors. Within this review, we aim to elucidate the multifaceted roles and effects of polyphenols on the skin, exploring their potential benefits as well as their capacity to act as ED agents. By delving into this intricate subject matter, we intend to provoke thoughtful consideration, effectively opening a Pandora’s box of questions for the reader to ponder. Ultimately, we invite the reader to contemplate whether polyphenols should be regarded as friends or foes in the realm of skincare and endocrine disruption

Cytogenetic and Molecular Predictors of Outcome in Acute Lymphocytic Leukemia: Recent Developments

During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T- acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles

Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie-Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription