Estudo clinico-epidemiologico das hepatites pos-transfusionais : papel dos principais marcadores sorologicos envolvidos na transfusão

Orientadores : Rogério de Jesus Pedro, Luiz Jacintho da SilvaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias MedicasResumo: Em 29833 doadores de sangue, estudados de outubro de 1985 até dezembro de 1989, medimos as prevalecias do H8sAg e do anti-HBc. pelo método de ELISA. A prevalencia para o HBsAg foi de 1,52% e para o anti-H8c de 11,05%. Entre 2783 doadores, com o padrão imunológico HBsAg negativa/anti-HBc positiva, 81,9X foram concomitantemente positivos para a anti-HBs. (...continua)DoutoradoDoutor em Ciências Médica

Occult hepatitis B virus infection in immunocompromised patients

Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients