Trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el Salvador, 2018

El presente trabajo de investigación tiene como nombre trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el Salvador, 2018 y tuvo como objetivo determinar la relación que existe entre trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el salvador, 2018. La población o universo de interés, está constituido por 120 estudiantes del nivel de secundaria de la institución educativa, la muestra está conformada por 92 estudiantes, en la cual se ha estudiado las variables: trabajo cooperativo y habilidades sociales. Esta investigación es de enfoque cuantitativo, de tipo correlacional por que tiene como propósito medir el grado de relación entre las dos variables, de diseño no experimental - transeccional. Para ello se aplicó el cuestionario como instrumento de investigación, esto es importante porque permite obtener información veraz acerca de la relación que existe entre las variables de estudio en sus distintas dimensiones. Que en los resultados obtenidos existe correlación directa y significativa entre trabajo cooperativo y habilidades sociales teniendo en cuenta que en la prueba estadística resultó Rho de Spearman R= 0.940, mientras que el p valor=0,000 y siendo este menor a 0,05 siendo rechazada la hipótesis nula

Trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el Salvador, 2018

El presente trabajo de investigación tiene como nombre trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el Salvador, 2018 y tuvo como objetivo determinar la relación que existe entre trabajo cooperativo y habilidades sociales de los estudiantes del tercero de secundaria del colegio “Héroes del Alto Cenepa” Villa el salvador, 2018. La población o universo de interés, está constituido por 120 estudiantes del nivel de secundaria de la institución educativa, la muestra está conformada por 92 estudiantes, en la cual se ha estudiado las variables: trabajo cooperativo y habilidades sociales. Esta investigación es de enfoque cuantitativo, de tipo correlacional por que tiene como propósito medir el grado de relación entre las dos variables, de diseño no experimental - transeccional. Para ello se aplicó el cuestionario como instrumento de investigación, esto es importante porque permite obtener información veraz acerca de la relación que existe entre las variables de estudio en sus distintas dimensiones. Que en los resultados obtenidos existe correlación directa y significativa entre trabajo cooperativo y habilidades sociales teniendo en cuenta que en la prueba estadística resultó Rho de Spearman R= 0.940, mientras que el p valor=0,000 y siendo este menor a 0,05 siendo rechazada la hipótesis nula

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohortResearch in context

Summary: Background: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs. Methods: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant of Concern (VoC), and physical and mental quality of life (QoL). Outcome of interest was identification of risk and protective factors of PCS by clinical phenotype, setting, severity of disease, treatment, and vaccination status. We used SF-36 questionnaire to assess evolution in QoL index during follow-up and unsupervised machine learning algorithms (principal component analysis, PCA) to explore symptom clusters. Severity of PCS was defined by clinical phenotype and QoL. We also used generalized linear models to analyse the impact of PCS on QoL and associated risk and preventive factors. CT registration number: NCT05097677. Findings: Among 1796 patients enrolled, 1030 (57%) suffered from at least one symptom at 12-month. PCA identified 4 clinical phenotypes: chronic fatigue-like syndrome (CFs: fatigue, headache and memory loss, 757 patients, 42%), respiratory syndrome (REs: cough and dyspnoea, 502, 23%); chronic pain syndrome (CPs: arthralgia and myalgia, 399, 22%); and neurosensorial syndrome (NSs: alteration in taste and smell, 197, 11%). Determinants of clinical phenotypes were different (all comparisons p < 0.05): being female increased risk of CPs, NSs, and CFs; chronic pulmonary diseases of REs; neurological symptoms at SARS-CoV-2 diagnosis of REs, NSs, and CFs; oxygen therapy of CFs and REs; and gastrointestinal symptoms at SARS-CoV-2 diagnosis of CFs. Early treatment of SARS-CoV-2 infection with monoclonal Ab (all clinical phenotypes), corticosteroids therapy for mild/severe cases (NSs), and SARS-CoV-2 vaccination (CPs) were less likely to be associated to PCS (all comparisons p < 0.05). Highest reduction in QoL was detected in REs and CPs (43.57 and 43.86 vs 57.32 in PCS-negative controls, p < 0.001). Female sex (p < 0.001), gastrointestinal symptoms (p = 0.034) and renal complications (p = 0.002) during the acute infection were likely to increase risk of severe PCS (QoL <50). Vaccination and early treatment with monoclonal Ab reduced the risk of severe PCS (p = 0.01 and p = 0.03, respectively). Interpretation: Our study provides new evidence suggesting that PCS can be classified by clinical phenotypes with different impact on QoL, underlying possible different pathogenic mechanisms. We identified factors associated to each clinical phenotype and to severe PCS. These results might help in designing pathogenesis studies and in selecting high-risk patients for inclusion in therapeutic and management clinical trials. Funding: The study received funding from the Horizon 2020 ORCHESTRA project, grant 101016167; from the Netherlands Organisation for Health Research and Development (ZonMw), grant 10430012010023; from Inserm, REACTing (REsearch &amp; ACtion emergING infectious diseases) consortium and the French Ministry of Health, grant PHRC 20-0424

International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module

We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care–associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line–associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U.S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN