Short-term memory binding in mild cognitive impairment

We showed that short-term memory (STM) binding is sensitive to sporadic and familial Alzheimer's disease (AD) but is not affected by healthy ageing, chronic depression in the elderly or other forms of dementia. STM binding deficits were also observed in individuals with a genetic susceptibility for AD in the preclinical stages. Hence, we aim to investigate longitudinally individuals with Mild Cognitive Impairment (MCI) using STM binding tasks. Here we report on preliminary cross-sectional results. A comprehensive neuropsychological test battery and a visual STM task were given to 21 MCI patients and 20 controls. The STM task required participants to recognise changes across two consecutive arrays presenting either single features (colour or shape) or feature bindings. The MCI group performed significantly poorer than controls on standard tests of memory, attention and on the binding condition of the STM task, but not on single feature conditions. Performance on the binding task and on standard memory tests did not correlate. Eight MCI patients clearly performed outwith the range of normality in the binding task. However, they did not significantly differ from the other 13 MCI patients in disease severity or demographic and neuropsychological variables. Six patients with binding impairments showed a multiple domain profile whereas ten patients with a preserved binding function showed an amnesic profile [Chi-square = 5.45, p = 0.020]. These results suggest that (1) the binding task is assessing a function different from other memory tests and that (2) STM binding may be differentially impaired in MCI subgroups

An Empirical Study of Real-World SPARQL Queries

Understanding how users tailor their SPARQL queries is crucial when designing query evaluation engines or fine-tuning RDF stores with performance in mind. In this paper we analyze 3 million real-world SPARQL queries extracted from logs of the DBPedia and SWDF public endpoints. We aim at finding which are the most used language elements both from syntactical and structural perspectives, paying special attention to triple patterns and joins, since they are indeed some of the most expensive SPARQL operations at evaluation phase. We have determined that most of the queries are simple and include few triple patterns and joins, being Subject-Subject, Subject-Object and Object-Object the most common join types. The graph patterns are usually star-shaped and despite triple pattern chains exist, they are generally short.Comment: 1st International Workshop on Usage Analysis and the Web of Data (USEWOD2011) in the 20th International World Wide Web Conference (WWW2011), Hyderabad, India, March 28th, 201

A novel peripheral biomarker for mild cognitive impairment and Alzheimer's disease

Background: Recent evidence suggests that oculomotor behaviours linked to cognitive performance can be a biomarker of Alzheimer’s disease (AD). Short-Term Memory Binding (STMB) declines in patients with AD dementia and in those at risk of dementia. STMB relies on brain regions relevant to visual processing which are known to support oculomotor behaviours. A combined analysis of oculomotor responses during STMB can enhance the sensitivity of the assessment of patients with AD or at risk of AD such as those with Mild Cognitive Impairment (MCI). We investigated this hypothesis. Methods: Using eye-tracking technologies, we measured pupil dilation, fixation, and exploratory eye movement behaviours in patients with AD, MCI and in healthy controls while they performed the STMBT. The STMBT assesses the ability to temporarily hold bicoloured objects whose colours had to be remembered either as individual features (baseline) or integrated within unified representations (binding). Results: Experiment 1 involved 18 healthy older adults and 18 patients with AD dementia. We observed (1) altered pupil dilation linked to poor STMB performance in AD patients. Experiment 2 involved 42 healthy older adults and 63 patients with MCI. Impaired fixation and exploratory eye movement behaviours accompanied poor STMB abilities in MCI patients. Conclusion: Taken together, the results above suggest that eye-tracking measures combined with cognitive markers for AD (STMBT) can (1) enrich the clinical phenotype of this type of dementia, (2) unveil novel features of AD dementia unknown to date, and (2) provide more sensitive tools which can detect and trace aspects of such phenotype in people at risk, thus helping to ascertain the presence of the prodromal stages of the disease

Vortex transmutation

Using group theory arguments and numerical simulations, we demonstrate the possibility of changing the vorticity or topological charge of an individual vortex by means of the action of a system possessing a discrete rotational symmetry of finite order. We establish on theoretical grounds a "transmutation pass rule'' determining the conditions for this phenomenon to occur and numerically analize it in the context of two-dimensional optical lattices or, equivalently, in that of Bose-Einstein condensates in periodic potentials.Comment: 4 pages, 4 figure

Forward-backward equations for nonlinear propagation in axially-invariant optical systems

We present a novel general framework to deal with forward and backward components of the electromagnetic field in axially-invariant nonlinear optical systems, which include those having any type of linear or nonlinear transverse inhomogeneities. With a minimum amount of approximations, we obtain a system of two first-order equations for forward and backward components explicitly showing the nonlinear couplings among them. The modal approach used allows for an effective reduction of the dimensionality of the original problem from 3+1 (three spatial dimensions plus one time dimension) to 1+1 (one spatial dimension plus one frequency dimension). The new equations can be written in a spinor Dirac-like form, out of which conserved quantities can be calculated in an elegant manner. Finally, these new equations inherently incorporate spatio-temporal couplings, so that they can be easily particularized to deal with purely temporal or purely spatial effects. Nonlinear forward pulse propagation and non-paraxial evolution of spatial structures are analyzed as examples.Comment: 11 page

Modelo local de simulación de nivel de napa freática en la Depresión del Salado

p.155-158A partir del esquema clásico del balance hidrológico seriado se elaboró un modelo que estima la variación mensual del nivel de napa freática a partir de las características físicas del suelo y de la precipitación y la evapotranspiración potencial mensuales. El modelo se ajustó tomando como referencia las series mensuales de las localidades de Dolores (1942-1977) y Chascomús (1945-1951). Pudo comprobarse que, tomando como partida los datos observados, el modelo reproduce ajustadamente el comportamiento de la napa durante 7 años, apartándose luego gradualmente. Por lo que posee capacidad para interpolar largos períodos faltantes en las series de observaciones, problema que se presenta frecuentemente con los registros de napa freática. El estudio se realizó para localidades situadas en la Depresión del Salado, lo que determina que el modelo sea de validez local ya que no se consideró el aporte de agua desde otras localidades debido a la escasa pendiente de la zona y a las características de drenaje de los suelos, las cuales determinan un movimiento vertical lento del agua debido a la presencia de horizontes de escasa permeabilidad

Cronología de inundaciones y sequías en el noreste de la provincia de Buenos Aires 1911 - 1989

p.241-249El objetivo del presente trabajo consistió en reproducir, por medio del balance hídrico del suelo, la cronología de inundaciones y sequías del Noreste de la Provincia de Buenos Aires y evaluar si la misma pudo darse dentro de un régimen de lluvias completamente aleatorio o si requirió que el mismo contuviera componentes determinísticas, como ciclos, periodicidades o saltos climáticos para producirse. Muchas de las series de datos mensuales empleadas presentaron una leve tendencia positiva, aunque en ningún caso resultó significativa debido a la alta variabilidad natural del fenómeno, que también puede ser interpretado como un salto de los promedios 1971-89 con respecto a los 1911-70, dado que tomados aisladamente ninguno de los dos períodos presenta tendencia. El análisis espectral reveló algunos picos levemente significativos y cuasi significativos, pero con una contribución muy pequeña a la variancia total, lo que hace descartar los efectos de procesos periódicos o cuasi periódicos. El estudio de rachas reveló que las de precipitación son completamente aleatorias y ráramente exceden los tres meses de duración, mientras que las de humedad del suelo muestran un proceso markoviano con alta persistencia pudiendo llegar a los 18 meses de extensión. Comparado con el período 1911 -70, el período 1971 -89 presentó un predominio de las rachas húmedas

Role of executive functions in the conversion from mild cognitive impairment to dementia

BACKGROUND: Recent research pointed to executive dysfunction as a potential early predictor of the progression of mild cognitive impairment (MCI) to dementia in Alzheimer's clinical syndrome (ACS). Such cognitive impairments account for functional impairments in instrumental activities of daily living (IADL). OBJECTIVE: The present study analyzes the contributions of executive functions to predict MCI-dementia progression in ACS. METHODS: We assessed 145 participants, 51 cognitively unimpaired and 94 MCI. The latter were divided using the traditional, memory-based MCI classification (single domain amnestic, multidomain amnestic, and non-amnestic). Eight tests assessing executive functions were administered at baseline and at 1-year follow-up, together with cognitive screening tools and IADL measures. MCI patients were reclassified based on the outcomes from a K-mean cluster analysis which identified three groups. A simple lineal regression model was used to examine whether the classification based on executive functioning could more accurately predict progression to dementia a year later. RESULTS: Clusters based on executive function deficits explained a significant proportion of the variance linked to MCI-dementia conversion, even after controlling for the severity of MCI at baseline (F(1, 68) = 116.25, p = 0.000, R2 = 0.63). Classical memory-based MCI classification failed to predict such a conversion (F(1, 68) = 5.09, p = 0.955, R2 = 0.07). Switching, categories generation, and planning were the executive functions that best distinguished between MCI converters and stable. CONCLUSION: MCI with a dysexecutive phenotype significantly predicts conversion to dementia in ACS a year later. Switching abilities and verbal fluency (categories) must be evaluated in MCI patients to assess risk of future dementia