Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair

We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a fibrin based blood clot. There are four basic interactions assumed in the model: fibroblasts orient the collagen matrix, fibroblasts produce and degrade collagen and fibrin and the matrix directs the fibroblasts and determines the speed of the cells. Several factors which influence the alignment of collagen are examined and related to current anti-scarring therapies using transforming growth factor ß. The most influential of these factors are cell speed and, more importantly for wound healing, the influx of fibroblasts from surrounding tissue

Counts and Sizes of Galaxies in the Hubble Deep Field - South: Implications for the Next Generation Space Telescope

Science objectives for the Next Generation Space Telescope (NGST) include a large component of galaxy surveys, both imaging and spectroscopy. The Hubble Deep Field datasets include the deepest observations ever made in the ultraviolet, optical and near infrared, reaching depths comparable to that expected for NGST spectroscopy. We present the source counts, galaxy sizes and isophotal filling factors of the HDF-South images. The observed integrated galaxy counts reach >500 galaxies per square arcminute at AB<30. We extend these counts to faint levels in the infrared using models. The trend previously seen that fainter galaxies are smaller, continues to AB=29 in the high resolution HDF-S STIS image, where galaxies have a typical half-light radius of 0.1 arcseconds. Extensive Monte Carlo simulations show that the small measured sizes are not due to selection effects until >29mag. Using the HDF-S NICMOS image, we show that galaxies are smaller in the near infrared than they are in the optical. We analyze the isophotal filling factor of the HDF-S STIS image, and show that this image is mostly empty sky even at the limits of galaxy detection, a conclusion we expect to hold true for NGST spectroscopy. At the surface brightness limits expected for NGST imaging, however, about a quarter of the sky is occupied by the outer isophotes of AB<30 galaxies. We discuss the implications of these data on several design concepts of the NGST near-infrared spectrograph. We compare the effects of resolution and the confusion limit of various designs, as well as the multiplexing advantages of either multi-object or full-field spectroscopy. We argue that the optimal choice for NGST spectroscopy of high redshift galaxies is a multi-object spectrograph (MOS) with target selection by a micro electro mechanical system (MEMS) device.Comment: 27 pages including 10 figures, accepted for publication in the Astronomical Journal, June 2000, abridged abstrac

Near-Infrared Survey of the GOODS-North Field: Search for Luminous Galaxy Candidates at z=>6.5

We present near-infrared (NIR; J & Ks) survey of the Great Observatories Origins Deep Survey-North (GOODS-N) field. The publicly available imaging data were obtained using the MOIRCS instrument on the 8.2m Subaru and the WIRCam instrument on the 3.6m Canada-France-Hawaii Telescope (CFHT). These observations fulfill a serious wavelength gap in the GOODS-N data - i.e., lack of deep NIR observations. We combine the Subaru/MOIRCS and CFHT/WIRCam archival data to generate deep J and Ks band images, covering the full GOODS-N field (~169 sq. arcmin) to an AB magnitude limit of ~25 mag (3sigma). We applied z'-band dropout color selection criteria, using the NIR data generated here. We have identified two possible Lyman Break Galaxy (LBG) candidates at z\gtrsim6.5 with J\lesssim24.5. The first candidate is a likely LBG at z\sim6.5 based on a weak spectral feature tentatively identified as Lyalpha line in the deep Keck/DEIMOS spectrum, while the second candidate is a possible LBG at z\sim7 based on its photometric redshift. These z'-dropout objects, if confirmed, are among the brightest such candidates found so far. At z\gtrsim6.5, their star formation rate is estimated as 100-200 solar mass per year. If they continue to form stars at this rate, they assemble a stellar mass of ~5x10^10 solar mass after about 400 million years, becoming the progenitors of massive galaxies observed at z\sim5. We study the implication of the z'-band dropout candidates discovered here, in constraining the bright-end of the luminosity function and understanding the nature of high redshift galaxies.Comment: ApJ in press, minor text/reference update

Spin gating electrical current

We use an aluminium single electron transistor with a magnetic gate to directly quantify the chemical potential anisotropy of GaMnAs materials. Uniaxial and cubic contributions to the chemical potential anisotropy are determined from field rotation experiments. In performing magnetic field sweeps we observe additional isotropic magnetic field dependence of the chemical potential which shows a non-monotonic behavior. The observed effects are explained by calculations based on the $\mathbf{k}\cdot\mathbf{p}$ kinetic exchange model of ferromagnetism in GaMnAs. Our device inverts the conventional approach for constructing spin transistors: instead of spin-transport controlled by ordinary gates we spin-gate ordinary charge transport.Comment: 5 pages, 4 figure

NGC 3312: A victim of ram pressure sweeping

Researchers are undertaking a volume limited survey of the Hydra I cluster in neutral hydrogen using the National Radio Astronomy Observatory's Very Large Array (VLA). The main purpose is to study the effects of a dense environment on the gaseous component of the galaxies. Observational evidence has been accumulating recently that ram pressure sweeping does occur in the centers of clusters, but it is possible that tidal interactions play a role as well. Results of high resolution HI imaging of NGC 3312, the large peculiar spiral near the cluster center are presented. Hydra I (= A1060) is the nearest rich cluster beyond Virgo and, as such, presents a unique opportunity to do a complete survey of a cluster. It is similar to the Virgo cluster in many of its general physical characteristics, such as size, x ray luminosity, velocity dispersion, and galaxy content (high spiral fraction). However, Hydra I appears to be more regular and relaxed. This is evident in the x ray distribution in its central region, which is radially symmetric and centered on the dominant galaxy, NGC 3311, a cD-like elliptical. The observed x ray luminosity implies a central gas density of 4.5 x 10 to the 3rd power cm(-3). Gallagher (1978) argued from optical images of NGC 3312 that this galaxy might be an ideal candidate to directly study effects of the ram pressure process; it might currently be undergoing stripping of its interstellar medium. The researchers' data are consistent with this suggestion, but other origins of the peculiar appearance cannot yet be ruled out