Mindfulness in informal caregivers of palliative patients

Abstract Objectives: Mindfulness is a concept of growing impact on psychotherapy and has been shown to be effective for stress reduction and to improve psychological well-being. Existential Behavioural Therapy (EBT) was developed to support relatives of palliative care (PC) patients to cope with their situation during caregiving and bereavement. Mindfulness training was a core element of the intervention. We investigated the relationship between mindfulness, mental distress, and psychological well-being in informal caregivers, and evaluated if the effects of the intervention were mediated by mindfulness. Methods: Relatives of PC inpatients took part in a randomized-controlled EBT trial and completed the Cognitive and Affective Mindfulness Scale-Revised, items from the Five Facets of Mindfulness as well as the Brief Symptom Inventory, the Satisfaction with Life Scale, the WHOQOL-BREF, a numerical rating scale on quality of life (range 0-10), and the Schedule for Meaning in Life Evaluation at pre- and post-intervention, and a 3- and 12-months follow-up. Results: One-hundred-and-thirty carers were included, most of them (71.6%) recently being bereaved at the beginning of the intervention. High correlations between mindfulness and mental distress (r=−0.51, p<0.001) as well as life satisfaction (r=0.52, p<0.001) were found. Mindfulness was a significant predictor of improvement in psychological distress, meaning in life and quality of life three months after the intervention. The EBT effects were partly mediated by mindfulness. Significance of results: Mindfulness seems to be a promising concept in supporting informal caregivers of PC patients. Further research is needed to identify the required format and intensity of mindfulness practice necessary for improvemen

Two different sides of &apos;chemobrain&apos;: determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study

Abstract Objective: Complaints of cognitive dysfunction are frequent among cancer patients. Many studies have identified neuropsychological compromise associated with cancer and cancer therapy; however, the neuropsychological compromise was not related to self-reported cognitive dysfunction. In this prospective study, the authors examined if confounding factors masked an underlying association of self-perceived cognitive function with actual cognitive performance. Determinants of self-perceived cognitive dysfunction were investigated. Methods: Self-perceived cognitive function and cognitive performance were assessed before treatment, at the end of treatment, and 1 year after baseline in 101 breast cancer patients randomized to standard versus intensified chemotherapy. Linear mixed-effects models were applied to test the relationships of performance on neuropsychological tests, patient characteristics, and treatment variables to self-reported cognitive function. Change of cognitive performance was tested as a predictor of change in self-reports. Results: Self-perceived cognitive function deteriorated during chemotherapy and had partially recovered 1 year after diagnosis. The personality trait negative affectivity, current depression, and chemotherapy regimen were consistently related to cognitive self-reports. No significant associations with performance in any of the 12 cognitive tests emerged. Change of cognitive performance was not reflected in self-reports of cognitive function. Conclusions: Neuropsychological compromise and self-perceived cognitive dysfunction are independent phenomena in cancer patients. Generally, cancer-associated neuropsychological compromise is not noticed by affected patients, but negative affectivity and treatment burden induce pessimistic self-appraisals of cognitive functioning regardless of the presence of neuropsychological compromise. Clinicians should consider this when determining adequate therapy for patients who complain of &apos;chemobrain&apos;. Copyright r 2010 John Wiley &amp; Sons, Ltd. Keywords: oncology; cancer; cognition disorders; adverse effects; neuropsychological tests; antineoplastic combined chemotherapy protocols Objective After cytostatic treatment, many cancer patients complain about cognitive side effects such as attention and memory problems. As a result of these reports, cognitive function in cancer patients has been investigated in a growing number of studies and the existence of chemotherapy-associated cognitive compromise has indeed been confirmed by many of them. However, with few exceptions, cognitive compromise as assessed by neuropsychological testing appeared to be unrelated to self-reported cognitive dysfunction. The divergence of objectively assessed cognitive function and subjective reports has been found pretreatmen

Protocol of an Interdisciplinary and Multidimensional Assessment of Pollution Reduction Measures in Urban Areas: MobilAir Project

International audienceMobility is a major source of greenhouse gas emissions. At the same time, urban air pollution is a major public health issue in both North and South countries. This project aims to show the synergies between short-term public health issues related to pollution and the reduction of greenhouse gas emissions. MobilAir, in a fundamentally interdisciplinary approach, aims to identify specific measures to significantly reduce urban air pollution and its impacts. Building on the multidisciplinary richness of the Grenoble campus, MobilAir will develop an integrated approach in the Grenoble urban area, a relevant pilot area. MobilAir aims to develop methods and tools that can be replicated in other cities in France or abroad. Specifically, MobilAir has three main objectives: (1) A better comprehension of the population’s exposure to pollution; (2) A detailed understanding of the determinants of mobility behaviour and (3) Support for public decision-making