Understanding Android Obfuscation Techniques: A Large-Scale Investigation in the Wild

In this paper, we seek to better understand Android obfuscation and depict a holistic view of the usage of obfuscation through a large-scale investigation in the wild. In particular, we focus on four popular obfuscation approaches: identifier renaming, string encryption, Java reflection, and packing. To obtain the meaningful statistical results, we designed efficient and lightweight detection models for each obfuscation technique and applied them to our massive APK datasets (collected from Google Play, multiple third-party markets, and malware databases). We have learned several interesting facts from the result. For example, malware authors use string encryption more frequently, and more apps on third-party markets than Google Play are packed. We are also interested in the explanation of each finding. Therefore we carry out in-depth code analysis on some Android apps after sampling. We believe our study will help developers select the most suitable obfuscation approach, and in the meantime help researchers improve code analysis systems in the right direction

UWB-INS Fusion Positioning Based on a Two-Stage Optimization Algorithm

Ultra-wideband (UWB) is a carrier-less communication technology that transmits data using narrow pulses of non-sine waves on the nanosecond scale. The UWB positioning system uses the multi-lateral positioning algorithm to accurately locate the target, and the positioning accuracy is seriously affected by the non-line-of-sight (NLOS) error. The existing non-line-of-sight error compensation methods lack multidimensional consideration. To combine the advantages of various methods, a two-stage UWB-INS fusion localization algorithm is proposed. In the first stage, an NLOS signal filter is designed based on support vector machines (SVM). In the second stage, the results of UWB and Inertial Navigation System (INS) are fused based on Kalman filter algorithm. The two-stage fusion localization algorithm achieves a great improvement on positioning system, it can improve the localization accuracy by 79.8% in the NLOS environment and by 36% in the (line-of-sight) LOS environment

SimiSketch: Efficiently Estimating Similarity of streaming Multisets

The challenge of estimating similarity between sets has been a significant concern in data science, finding diverse applications across various domains. However, previous approaches, such as MinHash, have predominantly centered around hashing techniques, which are well-suited for sets but less naturally adaptable to multisets, a common occurrence in scenarios like network streams and text data. Moreover, with the increasing prevalence of data arriving in streaming patterns, many existing methods struggle to handle cases where set items are presented in a continuous stream. Consequently, our focus in this paper is on the challenging scenario of multisets with item streams. To address this, we propose SimiSketch, a sketching algorithm designed to tackle this specific problem. The paper begins by presenting two simpler versions that employ intuitive sketches for similarity estimation. Subsequently, we formally introduce SimiSketch and leverage SALSA to enhance accuracy. To validate our algorithms, we conduct extensive testing on synthetic datasets, real-world network traffic, and text articles. Our experiment shows that compared with the state-of-the-art, SimiSketch can improve the accuracy by up to 42 times, and increase the throughput by up to 360 times. The complete source code is open-sourced and available on GitHub for reference

A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma

Glioblastoma (GBM) is the most lethal primary brain tumor in the central nervous system with limited therapeutic strategies to prolong the survival rate in clinic. TNF-related apoptosis-inducing ligand (TRAIL)-based strategy has been demonstrated to induce cell death in an extensive spectrum of tumor cells, including GBM, while a considerable proportion of malignant cells are resistant to TRAIL-induced apoptosis. MiR-137 is highly expressed in the brain, but significantly decreases with advanced progression of GBM. However, the functional link between miR-137 and TRAIL-induced apoptosis in GBM cells has not been established. Here, GBM cells were transfected with miR-137, and gene expression levels were examined by qRT-PCR and western blot. Apoptotic cells were measured by Annexin-V staining and TUNEL assay. Our data showed that miR-137 sensitizes GBM cells to the TRAIL-mediated apoptosis. Mechanistically, we identified that XIAP is a bona fide target of miR-137, which is essential for miR-137-regulated sensitivity of TRAIL-induced cell death in GBM cells. Finally, in a xenograft model, combined utilization of miR-137 and TRAIL potently suppresses tumor growth in vivo. Collectively, we demonstrate that a miR-137-XIAP axis is required for the sensitivity of TRAIL-induced cell death and shed a light on the avenue for the treatment of GBM

A Survey of Foundation Models for Music Understanding

Music is essential in daily life, fulfilling emotional and entertainment needs, and connecting us personally, socially, and culturally. A better understanding of music can enhance our emotions, cognitive skills, and cultural connections. The rapid advancement of artificial intelligence (AI) has introduced new ways to analyze music, aiming to replicate human understanding of music and provide related services. While the traditional models focused on audio features and simple tasks, the recent development of large language models (LLMs) and foundation models (FMs), which excel in various fields by integrating semantic information and demonstrating strong reasoning abilities, could capture complex musical features and patterns, integrate music with language and incorporate rich musical, emotional and psychological knowledge. Therefore, they have the potential in handling complex music understanding tasks from a semantic perspective, producing outputs closer to human perception. This work, to our best knowledge, is one of the early reviews of the intersection of AI techniques and music understanding. We investigated, analyzed, and tested recent large-scale music foundation models in respect of their music comprehension abilities. We also discussed their limitations and proposed possible future directions, offering insights for researchers in this field.20 pages, 2 figure

A Systematic Analysis on DNA Methylation and the Expression of Both mRNA and microRNA in Bladder Cancer

Background: DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in bladder urothelial carcinoma has never been reported. Methodology/Principal Findings: The DNA methylation was profiled by modified methylation-specific digital karyotyping (MMSDK) and the expression of mRNAs and miRNAs was analyzed by digital gene expression (DGE) sequencing in tumors and matched normal adjacent tissues obtained from 9 bladder urothelial carcinoma patients. We found that a set of significantly enriched pathways disrupted in bladder urothelial carcinoma primarily related to "neurogenesis" and "cell differentiation" by integrated analysis of -omics data. Furthermore, we identified an intriguing collection of cancer-related genes that were deregulated at the levels of DNA methylation and mRNA expression, and we validated several of these genes (HIC1, SLIT2, RASAL1, and KRT17) by Bisulfite Sequencing PCR and Reverse Transcription qPCR in a panel of 33 bladder cancer samples. Conclusions/Significance: We characterized the profiles between methylome and transcriptome in bladder urothelial carcinoma, identified a set of significantly enriched key pathways, and screened four aberrantly methylated and expressed genes. Conclusively, our findings shed light on a new avenue for basic bladder cancer research