8 research outputs found
Euroforgen-NoE collaborative exercise on LRmix to demonstrate standardization of the interpretation of complex DNA profiles
Get PDFSmaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation
Get PDFS-foci, the first reported mRNA-silencing foci specific to neurons, may control local mRNA translation in response to NMDA receptor stimulation and synaptic plasticity
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping
No full textIdentification and characterisation of a cluster of transcription start sites in the E6 ORF of the Human Papillomavirus type 16
No full textChronic obstructive pulmonary disease increases the cost of health-care services and social benefits
No full textChronic obstructive pulmonary disease involves substantial health-care service and social benefit costs
No full textKronisk obstruktiv lungesygdom fører til stort forbrug af sundhedsydelser og sociale udgifter
No full textA human microprotein that interacts with the mRNA decapping complex
No full textProteomic detection of non-annotated microproteins indicates the translation of hundreds of small open reading frames in human cells, but whether these microproteins are functional is unknown. Here, we report the discovery and characterization of a 7-kilodalton human microprotein we named non-annotated P-body dissociating polypeptide (NoBody). NoBody interacts with mRNA decapping proteins, which remove the 5’ cap from mRNAs to promote 5’-3’ decay. Decapping proteins participate in mRNA turnover and nonsense mediated decay (NMD). NoBody localizes to mRNA decay-associated RNA-protein granules called P-bodies. Modulation of NoBody levels reveals that its abundance is anti-correlated with cellular P-body numbers and alters the steady-state levels of a cellular NMD substrate. These results implicate NoBody as a novel component of the mRNA decapping complex and demonstrate potential functionality of a newly discovered microprotein
