731 research outputs found
Different critical points of chiral and deconfinement phase transitions in (2+1)-dimensional fermion-gauge interacting model
Based on the truncated Dyson-Schwinger equations for fermion and massive
boson propagators in QED, the fermion chiral condensate and the mass
singularities of the fermion propagator via the Schwinger function are
investigated. It is shown that the critical point of chiral phase transition is
apparently different from that of deconfinement phase transition and in Nambu
phase the fermion is confined only for small gauge boson mass.Comment: 5 Pages and 3 figure
New Method for Numerically Solving the Chemical Potential Dependence of the Dressed Quark Propagator
Based on the rainbow approximation of Dyson-Schwinger equation and the
assumption that the inverse dressed quark propagator at finite chemical
potential is analytic in the neighborhood of , a new method for
obtaining the dressed quark propagator at finite chemical potential from
the one at zero chemical potential is developed. Using this method the dressed
quark propagator at finite chemical potential can be obtained directly from the
one at zero chemical potential without the necessity of numerically solving the
corresponding coupled integral equations by iteration methods. A comparison
with previous results is given.Comment: Revtex, 14 pages, 5 figure
General formula for the four-quark condensate and vacuum factorization assumption
By differentiating the dressed quark propagator with respect to a variable
background field, the linear response of the dressed quark propagator in the
presence of the background field can be obtained. From this general method,
using the vector background field as an illustration, we derive a general
formula for the four-quark condensate . This formula contains the
corresponding fully dressed vector vertex and it is shown that factorization
for holds only when the dressed vertex is taken to be the bare one.
This property also holds for all other type of four-quark condensate.Comment: Revtex4, 11 pages, no figure
Signatures of magnetic reconnection at boundaries of interplanetary small-scale magnetic flux ropes
The interaction between interplanetary small-scale magnetic flux ropes and
the magnetic field in the ambient solar wind is an important topic to
understand- ing the evolution of magnetic structures in the heliosphere.
Through a survey of 125 previously reported small flux ropes from 1995 to 2005,
we find that 44 of them reveal clear signatures of Alfvenic fluctuations, and
thus classify them into Alfven wave trains rather than flux ropes. Signatures
of magnetic reconnection, generally including a plasma jet of ~30 km/s within a
magnetic field rotational region, are clearly present at boundaries of about
42% of the flux ropes and 14% of the wave trains. The reconnection exhausts are
often observed to show a local increase in the proton temperature, density and
plasma beta. About 66% of the reconnection events at flux rope boundaries are
associated with a magnetic field shear angle larger than 90 deg and 73% of them
reveal a decrease by 20% or more in the magnetic field magnitude, suggesting a
dominance of anti-parallel reconnec- tion at flux rope boundaries. The
occurrence rate of magnetic reconnection at flux rope boundaries through the
year of 1995 to 2005 is also investigated and we find that it is relatively low
around solar maximum and much higher when ap- proaching solar minima. The
average magnetic field depression and shear angle for reconnection events at
flux rope boundaries also reveal a similar trend from 1995 to 2005. Our results
demonstrate for the first time that boundaries of a substantial fraction of
small-scale flux ropes have properties similar to those of magnetic clouds, in
the sense that both of them exhibit signatures of magnetic reconnection. The
observed reconnection signatures could be related either to the formation of
small flux ropes, or to the interaction between flux ropes and the
interplanetary magnetic fields.Comment: 10 figures, accepted by Ap
Metformin downregulates PD-L1 expression in esophageal squamous cell catrcinoma by inhibiting IL-6 signaling pathway
Purpose: To characterize the mechanism by which metformin inhibits PD-L1 expression in esophageal squamous cell carcinoma (ESCC) and to evaluate the effect of metformin on the antitumor immune response.
Methods: The Cancer Genome Atlas (TCGA) database was used to analyze the correlations between IL-6 and prognosis and between IL-6 and PD-L1 gene expression in esophageal cancer. Reverse transcription-quantitative polymerase chain reaction (RT-PCR), Western blotting and immunofluorescence were used to study the mechanism by which metformin affects PD-L1 expression. Additionally, T cell function was assessed in a coculture system containing ESCC cells and peripheral blood mononuclear cells (PBMCs) treated with metformin or IL-6. In an
Results: The TCGA esophageal cancer data showed that IL-6 expression was positively correlated with PD-L1 expression and that patients with high IL-6 expression had a significantly lower overall survival rate than patients with low IL-6 expression. PD-L1 expression in ESCC cell lines was significantly inhibited by metformin
Conclusions: Metformin downregulated PD-L1 expression by blocking the IL-6/JAK2/STAT3 signaling pathway in ESCC, which enhanced the antitumor immune response
- …