Research and Practice on Key Issues in Teaching Reform of Application-Oriented Software Engineering Course

Aiming at the key problems encountered in the teaching of software engineering, this paper puts forward a series of innovative measures of teaching reform. Rebuild the course content according to the actual demand of enterprise posts; adopt the application ability-oriented “five-in-one” online and offline brand-new mixed teaching mode to create a student-centered deep learning; realize the transformation of academic evaluation from “graded by final examination scores” to “diversified process assessment”. The practice proves that the application-oriented software engineering course reform and innovation accord with the requirement of the applied talents cultivating target, and can be used for reference to the class teaching reform of computer courses

Kinetic behavior of the general modifier mechanism of Botts and Morales with non-equilibrium binding

In this paper, we perform a complete analysis of the kinetic behavior of the general modifier mechanism of Botts and Morales in both equilibrium steady states and non-equilibrium steady states (NESS). Enlightened by the non-equilibrium theory of Markov chains, we introduce the net flux into discussion and acquire an expression of product rate in NESS, which has clear biophysical significance. Up till now, it is a general belief that being an activator or an inhibitor is an intrinsic property of the modifier. However, we reveal that this traditional point of view is based on the equilibrium assumption. A modifier may no longer be an overall activator or inhibitor when the reaction system is not in equilibrium. Based on the regulation of enzyme activity by the modifier concentration, we classify the kinetic behavior of the modifier into three categories, which are named hyperbolic behavior, bell-shaped behavior, and switching behavior, respectively. We show that the switching phenomenon, in which a modifier may convert between an activator and an inhibitor when the modifier concentration varies, occurs only in NESS. Effects of drugs on the Pgp ATPase activity, where drugs may convert from activators to inhibitors with the increase of the drug concentration, are taken as a typical example to demonstrate the occurrence of the switching phenomenon.Comment: 19 pages, 10 figure

Coherent transport on Apollonian networks and continuous-time quantum walks

We study the coherent exciton transport on Apollonian networks generated by simple iterative rules. The coherent exciton dynamics is modeled by continuous-time quantum walks and we calculate the transition probabilities between two nodes of the networks. We find that the transport depends on the initial nodes of the excitation. For networks less than the second generation the coherent transport shows perfect revivals when the initial excitation starts at the central node. For networks of higher generation, the transport only shows partial revivals. Moreover, we find that the excitation is most likely to be found at the initial nodes while the coherent transport to other nodes has a very low probability. In the long time limit, the transition probabilities show characteristic patterns with identical values of limiting probabilities. Finally, the dynamics of quantum transport are compared with the classical transport modeled by continuous-time random walks.Comment: 5 pages, 6 figues. Submitted to Phys. ReV.

Is the late near-infrared bump in short-hard GRB 130603B due to the Li-Paczynski kilonova?

Short-hard gamma-ray bursts (GRBs) are widely believed to be produced by the merger of two binary compact objects, specifically by two neutron stars or by a neutron star orbiting a black hole. According to the Li-Paczynski kilonova model, the merger would launch sub-relativistic ejecta and a near-infrared/optical transient would then occur, lasting up to days, which is powered by the radioactive decay of heavy elements synthesized in the ejecta. The detection of a late bump using the {\em Hubble Space Telescope} ({\em HST}) in the near-infrared afterglow light curve of the short-hard GRB 130603B is indeed consistent with such a model. However, as shown in this Letter, the limited {\em HST} near-infrared lightcurve behavior can also be interpreted as the synchrotron radiation of the external shock driven by a wide mildly relativistic outflow. In such a scenario, the radio emission is expected to peak with a flux of $\sim 100 \mu$Jy, which is detectable for current radio arrays. Hence, the radio afterglow data can provide complementary evidence on the nature of the bump in GRB 130603B. It is worth noting that good spectroscopy during the bump phase in short-hard bursts can test validity of either model above, analogous to spectroscopy of broad-lined Type Ic supernova in long-soft GRBs.Comment: 4 pages, 2 figures, published in ApJ Lette

Protective effect of Acorus tatarinowii extract against alzheimer in 3xTg-AD mice

Purpose: To investigate the protective effect of Acorus tatarinowii extract (ATE) against Alzheimer's disease in 3xTg-AD mice. Method: The cognitive function of 3xTg-AD mice was assessed using Morris water maze test. The levels of the amyloid beta deposits and NeuN in the hippocampus were evaluated by immunohistochemical assay while brain neurotrophic derived factor (BDNF) and tyrosine kinase B (TrkB) expressions were determined by western blot analysis. Results: ATE treatment significantly ameliorated learning and memory deficits in AD mice, as shown by increased time spent in the target zone during probe tests. The escape latency in animals treated with 600 mg/kg ATE (24.8 ± 1.3 s) was significantly increased relative to ontreated 3xTg-AD mice (8.5 ± 1.0 s, p < 0.01). In addition, ATE significantly decreased Aβ deposits, increased NeuN-positive cells, and upregulated the expression of BDNF (1.9 ± 0.4, p < 0.05) and TrkB (1.9 ± 0.2, p < 0.05) in 3xTg AD mice. Conclusion: These results suggest that ATE treatment may be a useful strategy for managing memory impairment induced by several neurodegenerative diseases

Generation of multiple plasmons in strontium niobates mediated by local field effects

Recently, an anomalous generation of multiple plasmons with large spectral weight transfer in the visible to ultraviolet range (energies below the band gap) has been experimentally observed in the insulating-like phase of oxygen-rich strontium niobium oxides (SrNbO$_{3+\delta}$). Here, we investigate the ground state and dielectric properties of SrNbO$_{3+\delta}$ as a function of $\delta$ by means of extensive first principle calculations. We find that in the random phase approximation by taking into account the local field effects (LFEs), our calculations are able to reproduce both the unconventional multiple generations of plasmons and spectral weight transfers, consistent with experimental data. Interestingly, these unconventional plasmons can be tuned by oxygen stoichiometry as well as microscopic superstructure. This unusual predominance of LFEs in this class of materials is ascribed to the strong electronic inhomogeneity and high polarizability and paves a new path to induce multiple plasmons in the untapped visible to ultraviolet ranges of insulating-like oxides