Digital finance in the context of common wealth helps regional economic development of high quality

Digital transformation has pass through aspects of social livelihood and manufacture services, and digital finance has become a new motor for progress with quality as the main goal of China’s financial condition. Here first elaborates on the connotation of progress with quality as the main goal, selects 20 indicators from five aspects of progress with quality as the main goal, necessity and progression productiveness, and measures the indicator weights using principal component analysis. Secondly, spatial panel information originate 30 all regions in China are used to study the coordinated action condition among mathematical finance and the progress with quality as the main goal regional financial condition using the spatial face-plate pattern. Finally, the coordinated action test and enclosure correlation are applied to verify coordinated action mathematical financial condition progression on capital situation in different regions high-quality development and the internal system of action. The empirical results show that the capital situation in different regions progression in China exhibits 86.67% more significant spatial autocorrelation, and the Moran I index values of the mathematical financial condition progression level and progress with quality as the main goal from 2010 to 2021 are both greater than 0, and both are important at the 1% magnitude, directive that the continuous create and progression of mathematical treasury supply important positive contribution to progress with quality as the main goal economic development. The research in here provides a acknowledge basis for strengthening the construction of mathematical infrastructure, improving the capital market and related policies, and expedite the digital reform transversion finance

Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway

Endothelium-dependent vasorelaxant injury leads to a lot of cardiovascular diseases. Both hydrogen sulfide (H2S) and nitric oxide (NO) are gasotransmitters, which play a critical role in regulating vascular tone. However, the interaction between H2S and NO in vasorelaxation is still unclear. ZYZ-803 was a novel H2S and NO conjugated donor developed by H2S-releasing moiety (S-propyl-L-cysteine (SPRC)) and NO-releasing moiety (furoxan). ZYZ-803 could time- and dose-dependently relax the sustained contraction induced by PE in rat aortic rings, with potencies of 1.5- to 100-fold greater than that of furoxan and SPRC. Inhibition of the generations of H2S and NO with respective inhibitors abolished the vasorelaxant effect of ZYZ-803. ZYZ-803 increased cGMP level and the activity of vasodilator stimulated phosphoprotein (VASP) in aortic rings, and those effects could be suppressed by the inhibitory generation of H2S and NO. Both the inhibitor of protein kinase G (KT5823) and the inhibitor of KATP channel (glibenclamide) suppressed the vasorelaxant effect of ZYZ-803. Our results demonstrated that H2S and NO generation from ZYZ-803 cooperatively regulated vascular tone through cGMP pathway, which indicated that ZYZ-803 had therapeutic potential in cardiovascular diseases

ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal the underlying mechanism. ZYZ-168 was administered to rats with coronary artery ligation over a period of six weeks. Ecocardiography and Masson staining showed that ZYZ-168 substantially improved cardiac function and reduced interstitial fibrosis. The expression of α–smooth muscle actin (α-SMA) and Collagen I were reduced as was the activity of matrix metalloproteinase 9 (MMP-9). These were related with decreased phosphorylation of ERK1/2 and expression of Rho-associated coiled-coil containing protein kinase 1 (ROCK1). In cardiac fibroblasts stimulated with TGF-β1, phenotypic switches of cardiac fibroblasts to myofibroblasts were observed. Inhibition of ERK1/2 phosphorylation or knockdown of ROCK1 expectedly reduced TGF-β1 induced fibrotic responses. ZYZ-168 appeared to inhibit the fibrotic responses in a concentration dependent manner, in part via a decrease in ROCK 1 expression through inhibition of the phosphorylation status of ERK1/2. For inhibition of ERK1/2 phosphorylation with a specific inhibitor reduced the activation of ROCK1. Considering its anti-apoptosis activity in MI, ZYZ-168 may be a potential drug candidate for treatment of MI-induced cardiac fibrosis

Precision Higgs physics at the CEPC

The discovery of the Higgs boson with its mass around 125 GeV by the ATLAS and CMS Collaborations marked the beginning of a new era in high energy physics. The Higgs boson will be the subject of extensive studies of the ongoing LHC program. At the same time, lepton collider based Higgs factories have been proposed as a possible next step beyond the LHC, with its main goal to precisely measure the properties of the Higgs boson and probe potential new physics associated with the Higgs boson. The Circular Electron Positron Collider~(CEPC) is one of such proposed Higgs factories. The CEPC is an $e^+e^-$ circular collider proposed by and to be hosted in China. Located in a tunnel of approximately 100~km in circumference, it will operate at a center-of-mass energy of 240~GeV as the Higgs factory. In this paper, we present the first estimates on the precision of the Higgs boson property measurements achievable at the CEPC and discuss implications of these measurements.Comment: 46 pages, 37 figure

Digital Finance in the Context of Common Wealth Helps Regional Economic Development of High Quality

Digital transformation has pass through aspects of social livelihood and manufacture services, and digital finance has become a new motor for progress with quality as the main goal of China’s financial condition. Here first elaborates on the connotation of progress with quality as the main goal, selects 20 indicators from five aspects of progress with quality as the main goal, necessity and progression productiveness, and measures the indicator weights using principal component analysis. Secondly, spatial panel information originate 30 all regions in China are used to study the coordinated action condition among mathematical finance and the progress with quality as the main goal regional financial condition using the spatial face-plate pattern. Finally, the coordinated action test and enclosure correlation are applied to verify coordinated action mathematical financial condition progression on capital situation in different regions high-quality development and the internal system of action. The empirical results show that the capital situation in different regions progression in China exhibits 86.67% more significant spatial autocorrelation, and the Moran I index values of the mathematical financial condition progression level and progress with quality as the main goal from 2010 to 2021 are both greater than 0, and both are important at the 1% magnitude, directive that the continuous create and progression of mathematical treasury supply important positive contribution to progress with quality as the main goal economic development. The research in here provides a acknowledge basis for strengthening the construction of mathematical infrastructure, improving the capital market and related policies, and expedite the digital reform transversion finance

Environmental Emissions from Chemical Etching Synthesis of Silicon Nanotube for Lithium Ion Battery Applications

Silicon nanotubes (SiNTs) have been researched as a promising anode material to replace graphite in next-generation lithium ion batteries. Chemical etching synthesis of SiNTs is a simple, controllable and scalable process for SiNT fabrication, but the environmental emissions are of grave concern. In this paper, the process emissions from chemical etching synthesis of SiNTs as anode for lithium ion batteries is studied through experimental techniques, considering the categories of aqueous wastes, gaseous emissions, aqueous nano-particle emissions, and gaseous aerosol emissions. The synthesized SiNTs are measured at 10 μm length and 1–2.2 μm diameter, and can maintain a specific capacity of over 800 mAh/g after 100 cycles in battery testing. In aqueous waste, the chemical compositions of all elements participating in the chemical etching are experimentally determined, with AgNO3 and Co(NO3)2 identified as the major pollutants. The only gaseous emission generated from the chemical etching synthesis process is H2, with 0.0088 ± 0.0002 mol H2 generated to produce 1.0 mg SiNTs. The aqueous nanoparticle sizes are found to be between 250 nm and 1540 nm. A large number of aerosol nanoparticle emissions of up to 2.96 × 107 particles/cm3 are detected through in situ experimental measurement

Experimental study of process emissions from atomic layer deposition of Al2O3 under various temperatures and purge time

© 2017 by ASME. Experimental investigations of process emissions from atomic layer deposition (ALD) of Al2O3 are accomplished under various temperatures and purge times to understand its environmental sustainability performance. About 93% of Trimethylaluminum (TMA) is found flowing through ALD system without deposition. 2-9 × 104 of ultrafine nanoparticles containing 51.9 ± 64.6% of C, 16.6 ± 60.9% of Al, 31.4 ± 64.1% of O are generated during each cycle of reactions. 0.34-0.38 cm3 of CH4 (25 °C, 1 atm), which takes up 45-51% of C contained in TMA is produced simultaneously. The concentration of nanoparticles drops with the increase of purge time. CH4 also has a trend of decreasing but acts more complex with the largest emission at a short purge time. Compared with temperature, which has limited effects on reactants, purge time changes the time of reaction as well as the degree of gas phase mixing, and therefore greatly influences ALD emissions

Identification of a Hydrogen-Sulfide-Releasing Isochroman-4-One Hybrid as a Cardioprotective Candidate for the Treatment of Cardiac Hypertrophy

Cardiac pathological hypertrophy is associated with undesirable epigenetic changes and causes maladaptive cardiac remodeling and heart failure, leading to high mortality rates. Specific drugs for the treatment of cardiac hypertrophy are still in urgent need. In the present study, a hydrogen-sulfide-releasing hybrid 13-E was designed and synthesized by appending p-hydroxythiobenzamide (TBZ), an H2S-releasing donor, to an analog of our previously discovered cardioprotective natural product XJP, 7,8-dihydroxy-3-methyl-isochromanone-4. This hybrid 13-E exhibited excellent H2S-generating ability and low cellular toxicity. The 13-E protected against cardiomyocyte hypertrophy In Vitro and reduced the induction of Anp and Bnp. More importantly, 13-E could reduce TAC-induced cardiac hypertrophy In Vivo, alleviate cardiac interstitial fibrosis and restore cardiac function. Unbiased transcriptomic analysis showed that 13-E regulated the AMPK signaling pathway and influenced fatty acid metabolic processes, which may be attributed to its cardioprotective activities

Spatial Effects of Digital Transformation, PM2.5 Exposure, Economic Growth and Technological Innovation Nexus: PM2.5 Concentrations in China during 2010–2020

Digital transformation can increase lending by commercial banks, which may have an impact on economic development and technological progress, thus affecting air pollution. However, a limited amount of literature has discussed the impact of the digital transformation of commercial banks (DTCB) on air pollution. Based on city-level data from 2010 to 2020, this study used a spatial Durbin model to explore the spatial effects of DTCB on air pollution. This study shows that DTCB significantly increases air pollution in local and surrounding cities. Heterogeneity analysis shows that DTCB increases local and surrounding city air pollution in non-innovative cities and cities with low digital economy development. However, in innovative cities and cities with high digital economy development, DTCB reduces PM2.5 emissions in local and surrounding cities. Mechanism analysis shows that DTCB has no significant impact on technological innovation, but significantly promotes economic development, thus increasing air pollution. From the perspective of DTCB, this paper deepens the research on digital finance and air pollution. Against the background of DTCB, the government should guide commercial banks to apply digital technology to increase lending for technology innovation and promote DTCB to achieve the dual goals of economic development and improvement in air quality