In Context

The present thesis seeks to show the influences to my artwork and describe the body of work found in my thesis exhibition, In Context. The role of family and childhood are discussed and related to the work. The feminist writers bell hooks, Jane Tompkins, and Hélène Cixous are cited as influential to the initial exploration of my content. Artists discussed include Louise Bourgeois, Kiki Smith, Annette Messager, and Robert Rauschenberg. It is further shown how poetry and prose evolve as the catalyst for content for my work and how this enforces my belief that only through examining the personal can we reveal the universal human condition

The \u3ci\u3eman\u3csub\u3ei\u3c/sub\u3e said she\u3csub\u3ei\u3c/sub\u3e would return\u3c/i\u3e: English pronominal gender in native Mandarin speaking learners, examined within a comprehensive theory of language acquisition

The project that led to this honors thesis was begun in the Fall semester of 2010, in a graduate-level psycholinguistics course taught by Dr. T. Daniel Seely. At that time, I was intensively studying Mandarin and had been living with a native speaker who was also in the process of learning English. The types of speech errors in her English, particularly the ones that appeared to have resulted from influence from her native Mandarin, interested me greatly. One of the most striking errors that she tended to make, however, was mis-matching English gender-marked pronouns with the gender of the referent. That is, she would frequently say things like The man driving the bus said she could bring me to Ann Arbor, or I love Lady Gaga, his style is so interesting

HIV/AIDS: Pregnancy & the Newborn

This presentation will review preconception counseling, testing, assessment, and therapy of both the mother\u27s and newborn\u27s HIV. Additionally, aspects of medical care prior to, throughout, and post-hospitalization of the mother\u27s and newborn\u27s HIV will be discussed. Lastly, the importance of continuation of care post hospitalization with an emphasis on adherence to medical care, issues associated with breastfeeding & pre-mastication, will be assessed

HIV Resistance and Care Update

Participants of this learning session will become familiar with the currently available antiretroviral medications through discussing the HIV replicative cycle, become familiar with the mechanism of action of ARVs and how mutations and resistance develops and review current HIV treatment guidelines

Cases in HIV: HIV discussion through interactive case studies

This presentation aims to address the current challenges in “Getting to Zero” and review hot topics and recurrent themes and questions presented throughout the year and within the current HIV literature through interactive audience participation. Cases will be presented in highlighting current HIV care. About the Presenter: Gregory S. Felzien, MD, AAHIVS Diplomat: Internal Medicine and Infectious Disease Medical Advisor Division of Health Protection/IDI-HIV Georgia Department of Public Health Gregory S. Felzien, MD, AAHIVS, received his medical degree from the University of Colorado School of Medicine, completed an internal medicine internship and residency at Vanderbilt University, and infectious disease fellowship training at the Medical University of South Carolina. He holds Internal Medicine and Adult Infectious Disease board certification and is certified as an American Academy of HIV Specialist. Dr. Felzien is currently the Medical Advisor within the Georgia Department of Public Health’s Division of Health Protection/IDI-HIV. He works with legislators, community partners across the state, state and local HIV policy, speaks at the local, state and national level, and focuses on the needs of rural HIV, other STDs, and hepatitis B/C positive individuals throughout the state. Dr. Felzien was a co-editor and co-author of a rural HIV book in 2017 (https://www.springer.com/us/book/9783319562384) and in his spare time is a beekeeper

Toward a GPU-Accelerated Immersed Boundary Method for Wind Forecasting Over Complex Terrain

A short-term wind power forecasting capability can be a valuable tool in the renewable energy industry to address load-balancing issues that arise from intermittent wind fields. Although numerical weather prediction models have been used to forecast winds, their applicability to micro-scale atmospheric boundary layer flows and ability to predict wind speeds at turbine hub height with a desired accuracy is not clear. To address this issue, we develop a multi-GPU parallel flow solver to forecast winds over complex terrain at the micro-scale, where computational domain size can range from meters to several kilometers. In the solver, we adopt the immersed boundary method and the Lagrangian dynamic large-eddy simulation model and extend them to atmospheric flows. The computations are accelerated on GPU clusters with a dual-level parallel implementation that interleaves MPI with CUDA. We evaluate the flow solver components against test problems and obtain preliminary results of flow over Bolund Hill, a coastal hill in Denmark

An Immersed Boundary Geometric Preprocessor for Arbitrarily Complex Terrain and Geometry

There is a growing interest to apply the immersed boundary method to compute wind fields over arbitrarily complex terrain. The computer implementation of an immersed boundary module into an existing flow solver can be accomplished with minor modifications to the rest of the computer program. However, a versatile preprocessor is needed at the first place to extract the essential geometric information pertinent to the immersion of an arbitrarily complex terrain inside a 3D Cartesian mesh. Errors in the geometric information can negatively impact the correct implementation of the immersed boundary method as part of the solution algorithm. Additionally, the distance field from the terrain is needed to implement various subgrid-scale turbulence models and to initialize wind fields over complex terrain. Despite the popularity of the immersed boundary method, procedures used in the geometric preprocessing stage have received less attention. The present study found that concave and convex regions of complex terrain are particularly challenging to process with existing procedures discussed in the literature. To address this issue, a geometric preprocessor with a distance field solver was presented, and the solver demonstrated its versatility for arbitrarily complex geometry, terrain, and urban environments. The distance field solver uses the initial distance field at the immersed boundaries and propagates it to the rest of the domain by solving the Eikonal equation with the fast sweeping method

Netrin-3 Peptide (C-19) is a Chemorepellent and a Growth Inhibitor in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e

The netrins are a family of signaling proteins expressed throughout the animal kingdom. Netrins play important roles in developmental processes such as axonal guidance and angiogenesis. Netrin-1, for example, can act as either a chemoattractant or a chemorepellent for axonal growth cones depending upon the concentration of the protein as well as the cell type. Netrin-1 acts as a growth factor in some mammalian cell types and is also expressed by some tumor cells. Netrin-3 appears to share some signaling apparatus with netrin-1, but is less widely expressed, and its physiological roles are much less understood. Netrin-3 is also used as a biomarker for some cancers as well as traumatic kidney injury. Tetrahymena thermophila are free-living, eukaryotic, ciliated protozoas used as a model system for studying chemorepellents and chemoattractants because their swimming behavior is readily observable under a microscope. We have previously found that netrin-1 peptide acts as a chemorepellent in Tetrahymena thermophila at concentrations ranging from micromolar to nanomolar. However, netrin-1 peptide does not affect growth in Tetrahymena at these concentrations. In our current study, we have found that related peptides, netrin-3 peptide (H-19 and C-19; Santa Cruz Biotechnology), act as chemorepellents in Tetrahymena thermophila at concentrations at or below 1 μg/ml. The same concentration of netrin-3 peptide reduces growth of Tetrahymena cultures by approximately 75%. We are currently conducting further studies to determine the mechanism through which these peptides are signaling

Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease.

Aging is characterized by a progressive decline in the function of adult tissues which can lead to neurodegenerative disorders. However, little is known about the correlation between protein changes in the subventricular zone (SVZ) and neurodegenerative diseases with age. In the present study, neural stem cells (NSCs) were derived from the SVZ on postnatal 7 d, 1 m, and 12 m-old mice. With age, NSCs exhibited increased SA-β-gal activity and decreased proliferation and pool size in the SVZ zone, and were associated with elevated inflammatory chemokines and cytokines. Furthermore, quantitative proteomics and ingenuity pathway analysis were used to evaluate the significant age-related alterations in proteins and their functions. Some downregulated proteins such as DPYSL2, TPI1, ALDH, and UCHL1 were found to play critical roles in the neurological disease and PSMA1, PSMA3, PSMC2, PSMD11, and UCHL1 in protein homeostasis. Taken together, we have provided valuable insight into the cellular and molecular processes that underlie aging-associated declines in SVZ neurogenesis for the early detection of differences in gene expression and the potential risk of neurological disease, which is beneficial in the prevention of the diseases

Miscellany

Art Writinghttps://digitalcommons.georgiasouthern.edu/miscell/1000/thumbnail.jp