Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis

Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treated patients (Standardised Mean Difference (SMD) −0.37, 95% confidence interval (CI) −0.55 to −0.20; p < 0.0001), with no difference in mean scores between patients and healthy controls after one year (SMD 0.01, 95% CI −0.18 to 0.20, p = 0.94). There was a tendency towards worsening symptoms for non-coeliac gluten sensitive patients during a blinded gluten challenge vs. placebo (SMD 0.21, 95% CI −0.58 to 0.15; p = 0.25). Our review supports the association between mood disorders and gluten intake in susceptible individuals. The effects of a GFD on mood in subjects without gluten-related disorders should be considered in future research

Polynomial Kernels for Weighted Problems

Kernelization is a formalization of efficient preprocessing for NP-hard problems using the framework of parameterized complexity. Among open problems in kernelization it has been asked many times whether there are deterministic polynomial kernelizations for Subset Sum and Knapsack when parameterized by the number $n$ of items. We answer both questions affirmatively by using an algorithm for compressing numbers due to Frank and Tardos (Combinatorica 1987). This result had been first used by Marx and V\'egh (ICALP 2013) in the context of kernelization. We further illustrate its applicability by giving polynomial kernels also for weighted versions of several well-studied parameterized problems. Furthermore, when parameterized by the different item sizes we obtain a polynomial kernelization for Subset Sum and an exponential kernelization for Knapsack. Finally, we also obtain kernelization results for polynomial integer programs

Expanding the expressive power of Monadic Second-Order logic on restricted graph classes

We combine integer linear programming and recent advances in Monadic Second-Order model checking to obtain two new algorithmic meta-theorems for graphs of bounded vertex-cover. The first shows that cardMSO1, an extension of the well-known Monadic Second-Order logic by the addition of cardinality constraints, can be solved in FPT time parameterized by vertex cover. The second meta-theorem shows that the MSO partitioning problems introduced by Rao can also be solved in FPT time with the same parameter. The significance of our contribution stems from the fact that these formalisms can describe problems which are W[1]-hard and even NP-hard on graphs of bounded tree-width. Additionally, our algorithms have only an elementary dependence on the parameter and formula. We also show that both results are easily extended from vertex cover to neighborhood diversity.Comment: Accepted for IWOCA 201

SWAT Operations Unmanned Vehicle

During SWAT operations, it is common to have a barricaded suspect who may be armed and a serious threat to SWAT team personnel. In these cases, sending a robot into harm\u27s way to assess the situation as opposed to an operator has become the standard. The purpose of this of this research was to design and develop an unmanned system for the City of Akron\u27s SWAT Team that can be injected into these scenarios to improve outcomes and mitigate risk to SWAT operators

The lability and liability of female ‘borderline’ sexuality: a feminist Foucauldian discourse analysis of Thompson et al’s (2017) ‘Sexuality and sexual health among female youth with borderline personality disorder pathology’

The purpose of this discourse study is to deconstruct how a journal article published in Early Intervention in Psychiatry, ‘Sexuality and sexual health among female youth with borderline personality disorder pathology’ (Thompson et al, 2017), constructs the sexuality of young women diagnosed with ‘borderline personality disorder’. The methodology used was Foucauldian discourse analysis, following Hook’s (2001) recommendation to re-situate a text within its socio-political location and among its material correlates, as well as analysing its intra-textual discursive features. The process of analysis involved repeated close readings of the text by Thompson et al (2017), with a focus on binary oppositions within the text, and the power/knowledge nexus in which it is situated. The analysis identified three key discourses at work in the text: the discourse of the academy, the discourse of dichotomy, and the discourse of ‘borderline’ sexuality, which contains a conceptually unstable paradox concerning female ‘borderline’ sexual agency. The consequences of these findings, their historical context, and implications for practice and classification are discussed

Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans

Recent work in neuroeconomics has shown that regions in orbitofrontal and medial prefrontal cortex encode the subjective value of different options during choice. However, these electrophysiological and neuroimaging studies cannot demonstrate whether such signals are necessary for value-maximizing choices. Here we used a paradigm developed in experimental economics to empirically measure and quantify violations of utility theory in humans with damage to the ventromedial frontal lobe (VMF). We show that people with such damage are more likely to make choices that violate the generalized axiom of revealed preference, which is the one necessary and sufficient condition for choices to be consistent with value maximization. These results demonstrate that the VMF plays a critical role in value-maximizing choice

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial

Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study. We randomized eligible patients for whom there was clinical uncertainty about the need to conduct a home visit to a randomized controlled trial; patients for whom a visit was judged ‘essential’ were enrolled into a cohort study. Setting: Stroke rehabilitation unit of teaching hospital. Participants: One hundred and twenty-six participants hospitalized following recent stroke. Interventions: Predischarge home visit or structured, hospital-based interview. Main outcome measures: The primary objective was to collect information on the feasibility of a randomized controlled trial, including eligibility, control intervention and outcome assessments. The primary outcome measure was the Nottingham Extended Activities of Daily Living Scale at one month after discharge from hospital. Secondary outcomes included mood, quality of life and costs at one week and one month following discharge. Results: Ninety-three people were allocated to the randomized controlled trial; 47 were randomized to intervention and 46 to control. Thirty-three were enrolled into the cohort study. More people were allocated to the randomized controlled trial as the study progressed. One hundred and thirteen people (90%) received the proposed intervention, although there was a need for stricter protocol adherence. Follow-up was good: at one month 114 (90%) were assessed. There were no significant differences between the groups in the randomized controlled trial for the primary outcome measure at one month. The average cost of a home visit was £208. Conclusion: A trial is feasible and warranted given the resource implications of predischarge occupational therapy home visits

Parameterized Complexity of Asynchronous Border Minimization

Microarrays are research tools used in gene discovery as well as disease and cancer diagnostics. Two prominent but challenging problems related to microarrays are the Border Minimization Problem (BMP) and the Border Minimization Problem with given placement (P-BMP). In this paper we investigate the parameterized complexity of natural variants of BMP and P-BMP under several natural parameters. We show that BMP and P-BMP are in FPT under the following two combinations of parameters: 1) the size of the alphabet (c), the maximum length of a sequence (string) in the input (l) and the number of rows of the microarray (r); and, 2) the size of the alphabet and the size of the border length (o). Furthermore, P-BMP is in FPT when parameterized by c and l. We complement our tractability results with corresponding hardness results

Student Subjectivity in the Marketised University

We present data from an exploratory qualitative interview-based pedagogical research project on the development of student agency in higher education. Our aim was to respond to Nick Zepke’s claim that what is often missing from the current neoliberal discourse of higher education ‘is students having a voice in what and how they learn and how they can action their voice in the wider community as agentic citizens.’ Informed by Lacanian discourse analysis, our project investigated the opportunities and threats facing some of our undergraduate students as they struggled to exercise agency and develop autonomy in the marketised university. Repeat interviews (n = 15) with final year students focussed on the psychosocial categories of power, affect, intersubjectivity and desire. The analysis was guided by Lacan’s theory of the four discourses, an account of the vicissitudes of agency. We found that students can move between discourses depending on the extent to which their agency (operationalised here as Lacan’s ‘object cause of desire,’ the objet petit a) was enabled or thwarted. Our critique of the metaphor of the ‘student journey’ addresses the implications for learning and teaching and the university’s mission to develop its students in light of perceived commercial pressures