62 research outputs found
Investigation of Equilibrium Temperatures and Average Laminar Heat-transfer Coefficients for the Front Half of Swept Circular Cylinders at a Mach Number of 6.9
An Investigation of the Characteristics of the NACA RM-10 (with and Without Fins) in the Langley 11-inch Hypersonic Tunnel at a Mach Number of 6.9
A Simple Method for Determining Heat Transfer, Skin Friction, and Boundary-Layer Thickness for Hypersonic Laminar Boundary-Layer Flows in a Pressure Gradient
A procedure based on the method of similar solutions is presented by which the skin friction, heat transfer, and boundary-layer thickness in a laminar hypersonic flow with pressure gradient may be rapidly evaluated if the pressure distribution is known. This solution, which at present is. restricted to power-law variations of pressure with surface distance, is presented for a wide range of exponents in the power law corresponding to both favorable and adverse pressure gradients. This theory has been compared to results from heat-transfer experiments on blunt-nose flat plates and a hemisphere cylinder at free-stream Mach numbers of 4 and 6.8. The flat-plate experiments included tests made at a Mach number of 6.8 over a range of angle of attack of +/- 10 deg. Reasonable agreement of the experimental and theoretical heat-transfer coefficients has been obtained as well as good correlation of the experimental results over the entire range of angle of attack studied. A similar comparison of theory with experiment was not feasible for boundary-layer-thickness data; however, the hypersonic similarity theory was found to account satisfactorily for the variation in boundary-layer thickness due to local pressure distribution for several sets of measurements
Spatial theory and human behavior
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45971/1/10110_2005_Article_BF01952731.pd
Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors
The topology of the gene-regulatory network has been extensively analyzed. Now, given
the large amount of available functional genomic data, it is possible to go beyond this and
systematically study regulatory circuits in terms of logic elements. To this end, we present
Loregic, a computational method integrating gene expression and regulatory network data,
to characterize the cooperativity of regulatory factors. Loregic uses all 16 possible twoinput-
one-output logic gates (e.g. AND or XOR) to describe triplets of two factors regulating
a common target. We attempt to find the gate that best matches each triplet’s observed
gene expression pattern across many conditions. We make Loregic available as a generalpurpose
tool (github.com/gersteinlab/loregic). We validate it with known yeast transcriptionfactor
knockout experiments. Next, using human ENCODE ChIP-Seq and TCGA RNA-Seq
data, we are able to demonstrate how Loregic characterizes complex circuits involving both
proximally and distally regulating transcription factors (TFs) and also miRNAs. Furthermore,
we show that MYC, a well-known oncogenic driving TF, can be modeled as acting independently
from other TFs (e.g., using OR gates) but antagonistically with repressing miRNAs.
Finally, we inter-relate Loregic’s gate logic with other aspects of regulation, such as indirect
binding via protein-protein interactions, feed-forward loop motifs and global
regulatory hierarchy
Recommended from our members
NACA Research Memorandums
Report presenting the average heat-transfer coefficients and equilibrium temperatures for the front half of an isothermal cylinder with a laminar boundary layer as determined by wind tunnel testing at Mach number 6.9 and a range of Reynolds numbers and sweep angles
Recommended from our members
NACA Research Memorandums
Report presenting an investigation of the aerodynamic characteristics of a model of the NACA RM-10 in the hypersonic tunnel at a Mach number of 6.9. Longitudinal pressure surveys were made on the body without fins at zero lift and at angles of attack. Results regarding the pressure distributions, forebody pressure forces, body forces, fin-body combination forces, pitching moment and center of pressure, variation of the zero-lift drag components with Reynolds number and Mach number, variation of the lift-curve slope and center of pressure with Mach number, and Schileren observations are provided
- …