Reducing the use of sugar in public schools: a randomized cluster trial

OBJETIVO Analisar a eficácia de ações de educação nutricional com merendeiras na redução da adição de açúcar na alimentação escolar e no próprio consumo. MÉTODOS Ensaio randomizado por conglomerado, controlado, conduzido em 20 escolas municipais na cidade metropolitana de Niterói, RJ, de março a dezembro de 2007. Programa de educação nutricional foi implementado nas escolas de intervenção, junto a merendeiras, usando mensagens, atividades e material educativo que encorajassem a redução da adição de açúcar na alimentação escolar e no consumo. A redução da disponibilidade de açúcar pelas escolas foi analisada por planilhas com dados da utilização dos itens do estoque. O consumo individual das merendeiras foi avaliado pelo uso de questionário de frequência de consumo alimentar. As medidas antropométricas foram realizadas de acordo com técnicas padronizadas e a variação na mudança do peso foi medida ao longo do estudo. RESULTADOS A redução da disponibilidade de açúcar ocorreu mais acentuadamente nas escolas de intervenção quando comparadas às escolas controle (-6,0 kg versus 3,4 kg), sem diferença estatisticamente significante (p = 0,21), embora o poder do estudo tenha sido baixo. Houve redução do consumo de doces e bebidas açucaradas nos dois grupos, mas o consumo de açúcar não apresentou diferenças estatisticamente significativas entre eles. Houve redução do peso e do consumo de energia total nos dois grupos, mas sem diferença estatisticamente significante entre eles e sem modificação dos percentuais de adequação dos macronutrientes em relação ao consumo de energia. CONCLUSÕES Não foi possível provar que a estratégia de redução da disponibilidade e do consumo de açúcar por merendeiras de escolas públicas se mostrou eficaz.OBJETIVO Analizar la eficacia de acciones de educación nutricional con las manipuladoras de alimentos en la reducción de la adición de azúcar en la alimentación escolar y en el propio consumo. MÉTODOS Ensayo aleatorio por conglomerado, controlado, conducido en 20 escuelas municipales en la ciudad metropolitana de Niterói, RJ, de marzo a diciembre de 2007. El programa de educación nutricional fue implementado en las escuelas de intervención, manipuladoras de alimentos, usando mensajes, actividades y material educativo de forma de incentivar la reducción en la adición de azúcar a los alimentos y en el consumo. La reducción de la disponibilidad de azúcar en las escuelas fue analizada por planillas con datos de la utilización de los ítems de almacenamiento. El consumo individual de las manipuladoras de alimentos fue evaluado a través de cuestionario de frecuencia de consumo alimentario. Las medidas antropométricas fueron realizadas de acuerdo con técnicas estandarizadas y la variación en el cambio de peso fue medida a lo largo del estudio. RESULTADOS La reducción de la disponibilidad de azúcar ocurrió de forma más acentuada en las escuelas de intervención al compararse con las escuelas control (-6,0 kg versus 3,4 kg), sin diferencia estadísticamente significativa (p= 0,21), a pesar de que el poder del estudio haya sido bajo. Hubo reducción en el consumo de dulces y bebidas azucaradas en los dos grupos, aunque el consumo de azúcar no presentó diferencias estadísticamente significativas entre ellos. Hubo reducción en el peso y en el consumo de energía total en los dos grupos, pero sin diferencia estadísticamente significativa entre ellos, y sin modificación en los porcentajes de adecuación de los macronutrientes con relación al consumo de energía. CONCLUSIONES No fue posible probar que la estrategia de reducción de la disponibilidad y de consumo de azúcar por las manipuladoras de alimentos de escuelas públicas se mostró eficaz.OBJECTIVE To test the efficacy of nutritional guidelines for school lunch cooks aiming to reduce added sugar in school meals and their own sugar intake. METHODS A controlled randomized cluster trial was carried out in twenty public schools in the municipality of Niteroi in Rio de Janeiro, Southeastern Brazil, from March to December 2007. A nutrition educational program was implemented in the schools in question through messages, activities and printed educational materials encouraging reduced levels of added sugar in school meals and in the school lunch cooks’ own intake. The reduced availability of added sugar in schools was evaluated using spreadsheets including data on the monthly use of food item supplies. The cooks’ individual food intake was evaluated by a Food Frequency Questionnaire. Anthropometric measurements were taken according to standardized techniques and variation in weight was measured throughout the duration of the study. RESULTS There was a more marked reduction in the intervention schools compared to the control schools (-6.0 kg versus 0.34 kg), but no statistically significant difference (p = 0.21), although the study power was low. Both groups of school lunch cooks showed a reduction in the consumption of sweets and sweetened beverages, but the difference in sugar intake was not statistically significant. Weight loss and a reduction in total energy consumption occurred in both groups, but the difference between them was not statistically significant, and there was no alteration in the percentages of adequacy of macronutrients in relation to energy consumption. CONCLUSIONS The strategy of reducing the use and consumption of sugar by school lunch cooks from public schools could not be proved to be effective

Influence of Physical Exercise on Advanced Glycation End Products Levels in Patients Living With the Human Immunodeficiency Virus

Introduction: Combined antiretroviral therapy (cART) used to treat acquired immunodeficiency virus (HIV) induces a number of adverse effects, such as insulin resistance and dyslipidemia, which ultimately increases the cardiovascular risk. Advanced glycation end products (AGEs) have been implicated in the etiology of cardiovascular diseases, diabetes and other chronic diseases. It is known that physical exercise improves the lipid profile, insulin resistance and reduces the risk of cardiovascular diseases. However, the impact of physical exercise on AGE levels in HIV-infected patients has not been so far investigated. Therefore, this study compared AGEs levels in people with and without HIV and verified the effect of physical training on serum AGE levels.Methods: Participants were initially assigned into three groups: healthy control (CTL, n = 35), physically inactive HIV-infected (In-HIV, n = 33) and physically active HIV-infected (Ac-HIV, n = 19). The In-HIV group underwent physical training for 3 months, consisting of 60-min sessions of multimodal supervised exercise (aerobic, resistance and flexibility) with moderate intensity (50–80% heart rate reserve), performed 3 times/week. AGEs were measured in serum by fluorescence spectrometry.Results: At baseline, serum AGEs fluorescence level was significantly higher in inactive HIV-patients when compared to controls or active HIV-patients (In-HIV: 0.93 ± 0.08 vs. controls: 0.68 ± 0.13 and Ac-HIV: 0.59 ± 0.04 A.U.; P < 0.001). Triglycerides were also higher in In-HIV than CTL (182.8 ± 102 vs. 132.8 ± 52.3 mg/dL; P < 0.05). Waist circumference was lower in Ac-HIV, compared to In-HIV and controls (83.9 ± 10.4 vs. 92.9 ± 13.5 and 98.3 ± 12.4, respectively; P < 0.05). Body mass, fasting blood glucose, LDL, HDL, and total cholesterol were similar between groups. After training, AGE levels decreased (Baseline: 0.93 ± 0.08 vs. 3 months follow-up: 0.59 ± 0.04 AU; P < 0.001), no further difference being detected vs. CTL or Ac-HIV. Conclusion: HIV-infected patients under cART exhibited elevated AGEs levels compared to healthy individuals and physically active patients. Short-term aerobic training of moderate intensity counteracted this condition

Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a small-volume, home-based exercise program

OBJECTIVE: Our objective was to evaluate the effects of small-volume, home-based exercise combined with slight caloric restriction on the inflammatory markers C-reactive protein and adiponectin. METHODS: In total, 54 women were randomly assigned to one of two groups for exercise intervention: the control or home-based exercise groups. Weight, waist and hip circumferences, and inflammatory markers were measured at baseline and after 6 and 12 months. Women allocated to the home-based exercise group received a booklet explaining the physical exercises to be practiced at home at least 3 times per week, 40 minutes per session, at low-to-moderate intensity. All participants received dietary counseling aimed at reducing caloric intake by 100-300 calories per day, with a normal distribution of macro-nutrients (26-28% of energy as fat). Clinicaltrials.gov: NCT01206413 RESULTS: The home-based exercise group showed a significantly greater reduction in weight and body mass index at six months, but no difference between groups was observed thereafter. With regard to the inflammatory markers, a greater but non-statistically significant reduction was found for C-reactive protein in the home-based exercise group at six months; however, this difference disappeared after adjusting for weight change. No differences in adiponectin were found at the 6- or 12-month follow-up. CONCLUSION: Small-volume, home-based exercise did not promote changes in inflammatory markers independent of weight change

Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions”

Coinfecciones; Trypanosoma cruzi; Enfermedades parasitariasCoinfeccions; Trypanosoma cruzi; Malalties parasitàriesCo-infections; Trypanosoma cruzi; Parasitic diseasesObjective Chagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T. cruzi)-HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates. Methods This is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological or one parasitological tests, and HIV infection confirmed by immunoblot. CDR was diagnosed by direct microscopy with detection of trypomastigote forms in the blood or other biological fluids and/or amastigote forms in inflammatory lesions. Results Out of 241 patients with co-infection, 86.7% were from Brazil, 47.5% had <200 CD4+ T cells/μL and median viral load was 17,000 copies/μL. Sixty CDR cases were observed. Death was more frequent in patients with reactivation and was mainly caused by CDR. Other causes of death unrelated to CDR were the manifestation of opportunistic infections in those with Acquired Immunodeficiency Syndrome. The time between the co-infection diagnosis to death was shorter in patients with CDR. Lower CD4+ cells count at co-infection diagnosis was independently associated with reactivation. Similarly, lower CD4+ cells numbers at co-infection diagnosis and male sex were associated with higher lethality in CDR. Additionally, CD4+ cells were lower in meningoencephalitis than in myocarditis and milder forms. Conclusion This study showed major features on T. cruzi-HIV co-infection and highlighted the prognostic role of CD4+ cells for reactivation and mortality. Since lethality was high in meningoencephalitis and all untreated patients died shortly after the diagnosis, early diagnosis, immediate antiparasitic treatment, patient follow-up and epidemiological surveillance are essentials in T. cruzi/HIV co-infection and CDR managements.The author(s) received no specific funding for this work

Difficulty in weaning and cardiopulmonary rehabilitation in inoperable severe mitral regurgitation: a case report

Objective: Severe mitral valve insufficiency may lead to heart failure and associated hemodynamic repercussions, such as congestion and weaning-induced pulmonary oedema. This slows weaning from mechanical ventilation, increases the length of the hospital stay, and worsens the patient's prognosis. Case report: The present report describes one strategy used for cardiopulmonary rehabilitation and to help wean a patient from mechanical ventilation, with prohibitive comorbidities that contra-indicate surgical mitral valve repair, using respiratory and peripheral muscle training associated with positive pressure ventilation. Discussion: The severe dysfunction of the mitral valve was considered to be surgically inoperable by the surgeon team. However, the weaning and rehabilitation challenges in this patient with severe chronic obstructive pulmonary disease, even with weaning-induced pulmonary edema occurrence, were overcome. The strategy to rehabilitate respiratory muscle force during positive pressure ventilation, concomitantly to a cardiopulmonary rehabilitation program, improved peripheral muscle strength and functionality, reducing energetic demand, allowing the weaning from mechanical ventilation. Conclusion: Despite the severity of the disease, with the adopted strategy it was possible to perform weaning of the mechanical ventilation, allowing the patient to survive with his relatives

Design of a school randomized trial for nudging students towards healthy diet and physical activity to prevent obesity:PAAPAS Nudge study protocol

Submitted by Janaína Nascimento ([email protected]) on 2019-06-26T13:41:43Z No. of bitstreams: 1 ve_Cunha_Diana_etal_INI_2017.pdf: 188285 bytes, checksum: 9c5af1590f81759ea357050b01c74cce (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-06-26T14:10:20Z (GMT) No. of bitstreams: 1 ve_Cunha_Diana_etal_INI_2017.pdf: 188285 bytes, checksum: 9c5af1590f81759ea357050b01c74cce (MD5)Made available in DSpace on 2019-06-26T14:10:20Z (GMT). No. of bitstreams: 1 ve_Cunha_Diana_etal_INI_2017.pdf: 188285 bytes, checksum: 9c5af1590f81759ea357050b01c74cce (MD5) Previous issue date: 2017State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil.State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil.State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil / Brazilian Navy. Naval Academy. Department of Physical Education and Sports. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Epidemiologia e Métodos Quantitativos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Institute of Collective Health. Department of Epidemiology and Biostatistics. Niterói, RJ, Brazil.State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Institute of Collective Health. Department of Epidemiology and Biostatistics. Niterói, RJ, Brazil.State University of Rio de Janeiro. Nutrition Institute. Department of Social Nutrition. Rio de Janeiro, RJ, Brazil.State University of Rio de Janeiro. Nutrition Institute. Department of Social Nutrition. Rio de Janeiro, RJ, Brazil.University of Copenhagen. Department of Food Science. Copenhagen, Denmark.Federal University of Rio de Janeiro. Department of Social and Applied Nutrition. Rio de Janeiro, RJ, Brazil.State University of Rio de Janeiro. Social Medicine Institute. Department of Epidemiology. Rio de Janeiro, RJ, Brazil.Objective: To evaluate the effectiveness of nudge activities at school on the students’ body mass index (BMI). Design: School-based factorial randomized community trial. Setting: Eighteen public schools in the municipality of Duque de Caxias, metropolitan area of Rio de Janeiro, Brazil. Participants and intervention: The 18 schools will be randomized into 4 group arms: group 1—control (without any activity); group 2—will receive educational activities in the classroom; group 3—will receive changes in the school environment (nudge strategies); group 4—will receive educational activities and changes in the school environment. Activities will occur during the 2018 school-year. Main outcomemeasure(s): The primary (BMI) and secondary (body fat percentage) outcomes will be assessed at baseline and after the study using a portable electronic scale with a segmental body composition monitor. The height will be measured by a portable stadiometer. Analysis: Statistical analyses for each outcome will be conducted through linear mixed models that took into account the missing data and cluster effect of the schools. Abbreviations: BMI = body mass index, CONSORT = Consolidated Standards of Reporting Trials, PAAPPAS = Portuguese abbreviation of parents, students, community health agents and teachers for healthy eating, Rec24-h = 24-hour recall, SLM = Smarter Lunchrooms Movement

Impact of COVID-19 In-hospital Mortality in Chagas Disease Patients

The COVID-19 virus infection caused by the new SARS-CoV-2 was first identified in Rio de Janeiro (RJ), Brazil, in March 2020. Until the end of 2021, 504,399 COVID-19 cases were confirmed in RJ, and the total death toll reached 68,347. The Evandro Chagas National Institute of Infectious Diseases from Oswaldo Cruz Foundation (INI-Fiocruz) is a referral center for treatment and research of several infectious diseases, including COVID-19 and Chagas disease (CD). The present study aimed to evaluate the impact of COVID-19 on in-hospital mortality of patients with CD during the COVID-19 pandemic period. This observational, retrospective, longitudinal study evaluated all patients with CD hospitalized at INI-Fiocruz from May 1, 2020, to November 30, 2021. One hundred ten hospitalizations from 81 patients with CD (58% women; 68 ± 11 years) were evaluated. Death was the study's main outcome, which occurred in 20 cases. The mixed-effects logistic regression was performed with the following variables to test whether patients admitted to the hospital with a COVID-19 diagnosis would be more likely to die than those admitted with other diagnoses: admission diagnosis, sex, age, COVID-19 vaccination status, CD clinical classification, and the number of comorbidities. Results from multiple logistic regression analysis showed a higher risk of in-hospital mortality in patients diagnosed with COVID-19 (OR 6.37; 95% CI 1.78–22.86) compared to other causes of admissions. In conclusion, COVID-19 infection had a significant impact on the mortality risk of INI-Fiocruz CD patients, accounting for one-third of deaths overall. COVID-19 presented the highest percentage of death significantly higher than those admitted due to other causes during the COVID-19 pandemic