High-density lipoprotein: does it have a dark side?

There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atherosclerosis, likely mediated by a change in the structure of HDL to pro-inflammatory HDL (PiHDL). Validation of the technically challenging assay for PiHDL, and confirmation of an association of PiHDL in multiple populations with known risk for atherosclerosis will eventually provide a useful biomarker. Identification of PiHDL in patients with rheumatic disease may help identify patients at risk of accelerated atherosclerosis, and focus our therapeutic interventions

Dissecting Massive YSOs with Mid-Infrared Interferometry

The very inner structure of massive YSOs is difficult to trace. With conventional observational methods we often identify structures still several hundreds of AU in size. But we also need information about the innermost regions where the actual mass transfer onto the forming high-mass star occurs. An innovative way to probe these scales is to utilise mid-infrared interferometry. Here, we present first results of our MIDI GTO programme at the VLTI. We observed 10 well-known massive YSOs down to scales of 20 mas. We clearly resolve these objects which results in low visibilities and sizes in the order of 30 - 50 mas. Thus, with MIDI we can for the first time quantify the extent of the thermal emission from the warm circumstellar dust and thus calibrate existing concepts regarding the compactness of such emission in the pre-UCHII region phase. Special emphasis will be given to the BN-type object M8E-IR where our modelling is most advanced and where there is indirect evidence for a strongly bloated central star.Comment: 8 pages, 6 figures, proceedings contribution for the conference "Massive Star Formation: Observations confront Theory", held in September 2007 in Heidelberg, Germany; to appear in ASP Conf. Ser. 387, H. Beuther et al. (eds.

Detecting Extrasolar Planets with Integral Field Spectroscopy

Observations of extrasolar planets using Integral Field Spectroscopy (IFS), if coupled with an extreme Adaptive Optics system and analyzed with a Simultaneous Differential Imaging technique (SDI), are a powerful tool to detect and characterize extrasolar planets directly; they enhance the signal of the planet and, at the same time, reduces the impact of stellar light and consequently important noise sources like speckles. In order to verify the efficiency of such a technique, we developed a simulation code able to test the capabilities of this IFS-SDI technique for different kinds of planets and telescopes, modelling the atmospheric and instrumental noise sources. The first results obtained by the simulations show that many significant extrasolar planet detections are indeed possible using the present 8m-class telescopes within a few hours of exposure time. The procedure adopted to simulate IFS observations is presented here in detail, explaining in particular how we obtain estimates of the speckle noise, Adaptive Optics corrections, specific instrumental features, and how we test the efficiency of the SDI technique to increase the signal-to-noise ratio of the planet detection. The most important results achieved by simulations of various objects, from 1 M_J to brown dwarfs of 30 M_J, for observations with an 8 meter telescope, are then presented and discussed.Comment: 60 pages, 37 figures, accepted in PASP, 4 Tables adde

VLTI observations of IRS~3: The brightest compact MIR source at the Galactic Centre

The dust enshrouded star IRS~3 in the central light year of our galaxy was partially resolved in a recent VLTI experiment. The presented observation is the first step in investigating both IRS~3 in particular and the stellar population of the Galactic Centre in general with the VLTI at highest angular resolution. We will outline which scientific issues can be addressed by a complete MIDI dataset on IRS~3 in the mid infrared.Comment: 4 pages, 3 figures, published in: The ESO Messenge

Ground truth deficiencies in software engineering: when codifying the past can be counterproductive

Many software engineering tools build and evaluate their models based on historical data to support development and process decisions. These models help us answer numerous interesting questions, but have their own caveats. In a real-life setting, the objective function of human decision-makers for a given task might be influenced by a whole host of factors that stem from their cognitive biases, subverting the ideal objective function required for an optimally functioning system. Relying on this data as ground truth may give rise to systems that end up automating software engineering decisions by mimicking past sub-optimal behaviour. We illustrate this phenomenon and suggest mitigation strategies to raise awareness

High-Resolution Infrared Imaging of Herschel 36 SE: A Showcase for the Influence of Massive Stars in Cluster Environments

We present high-resolution infrared imaging of the massive star-forming region around the O-star Herschel 36. Special emphasis is given to a compact infrared source at 0".25 southeast of the star. The infrared source, hereafter Her 36 SE, is extended in the broad-band images, but features spatially unresolved Br gamma line emission. The line-emission source coincides in position with the previous HST detections in H alpha and the 2 cm radio continuum emission detected by VLA interferometry. We propose that the infrared source Her 36 SE harbors an early B-type star, deeply embedded in a dusty cloud. The fan shape of the cloud with Herschel 36 at its apex, though, manifests direct and ongoing destructive influence of the O7V star on Her 36 SE

Wireless capsule endoscopy for the detection of small bowel diseases in HIV-1-infected patients

<p>Abstract</p> <p>Background and Aims</p> <p>In HIV-infected patients, manifestations of the disease are common in the gastrointestinal tract. The objective of our study was to evaluate the diagnostic yield of the Given^®Video Capsule System (Given Imaging, Yoqneam, Israel) in these patients.</p> <p>Methods</p> <p>After exclusion of GI-tract stenosis by anamnestic exploration, 49 patients were included into the study. Stratification: Group A (n = 19): HIV-positive, CD₄cell count < 200/μl, gastrointestinal symptoms present. Group B: HIV-positive, CD₄< 200/μl, without gastrointestinal symptoms (n = 19 Group) C: healthy volunteers (n = 11).</p> <p>Results</p> <p>In group A there was a total of 30 pathological findings, 15 of which with therapeutic implications. In group B, there was a total of 22 pathological findings, 5 relevant for therapy. In group C there was a total of 13 pathological findings, 3 with therapeutic relevance. In 89% (group A) vs. 26% (group B), pathological findings were detected distal the ligament of Treitz (p = 0.001). All capsules were recovered without complications after 12 to 96 h from the stool.</p> <p>Conclusion</p> <p>Wireless capsule endoscopy of the small intestine should be considered for HIV-infected patients with marked immunosuppression and gastrointestinal symptoms.</p

Mid-infrared interferometry of massive young stellar objects. I. VLTI and Subaru observations of the enigmatic object M8E-IR

[abridged] Our knowledge of the inner structure of embedded massive young stellar objects is still quite limited. We attempt here to overcome the spatial resolution limitations of conventional thermal infrared imaging. We employed mid-infrared interferometry using the MIDI instrument on the ESO/VLTI facility to investigate M8E-IR, a well-known massive young stellar object suspected of containing a circumstellar disk. Spectrally dispersed visibilities in the 8-13 micron range were obtained at seven interferometric baselines. We resolve the mid-infrared emission of M8E-IR and find typical sizes of the emission regions of the order of 30 milli-arcseconds (~45 AU). Radiative transfer simulations have been performed to interpret the data. The fitting of the spectral energy distribution, in combination with the measured visibilities, does not provide evidence for an extended circumstellar disk with sizes > 100 AU but requires the presence of an extended envelope. The data are not able to constrain the presence of a small-scale disk in addition to an envelope. In either case, the interferometry measurements indicate the existence of a strongly bloated, relatively cool central object, possibly tracing the recent accretion history of M8E-IR. In addition, we present 24.5 micron images that clearly distinguish between M8E-IR and the neighbouring ultracompact HII region and which show the cometary-shaped infrared morphology of the latter source. Our results show that IR interferometry, combined with radiative transfer modelling, can be a viable tool to reveal crucial structure information on embedded massive young stellar objects and to resolve ambiguities arising from fitting the SED.Comment: 7 pages, 5 figures, accepted for publication in A&A, new version after language editing, one important reference added, conclusions unchange

The VLTI/MIDI survey of massive young stellar objects - Sounding the inner regions around intermediate- and high-mass young stars using mid-infrared interferometry

We aim to characterize the distribution and composition of circumstellar material around young massive stars, and to investigate exactly which physical structures in these objects are probed by long-baseline mid-infrared interferometric observations. We used the two-telescope interferometric instrument MIDI of the Very Large Telescope Interferometer of the European Southern Observatory to observe a sample of 24 intermediate- and high-mass young stellar objects in the N band (8-13 micron). We had successful fringe detections for 20 objects, and present spectrally-resolved correlated fluxes and visibility levels for projected baselines of up to 128 m. We fit the visibilities with geometric models to derive the sizes of the emitting regions, as well as the orientation and elongation of the circumstellar material. Fourteen objects in the sample show the 10 micron silicate feature in absorption in the total and correlated flux spectra. For 13 of these objects, we were able to fit the correlated flux spectra with a simple absorption model, allowing us to constrain the composition and absorptive properties of the circumstellar material. Nearly all of the massive young stellar objects observed show significant deviations from spherical symmetry at mid-infrared wavelengths. In general, the mid-infrared emission can trace both disks and outflows, and in many cases it may be difficult to disentangle these components on the basis of interferometric data alone, because of the sparse spatial frequency coverage normally provided by current long-baseline interferometers. For the majority of the objects in this sample, the absorption occurs on spatial scales larger than those probed by MIDI. Finally, the physical extent of the mid-infrared emission around these sources is correlated with the total luminosity, albeit with significant scatter.Comment: 36 pages, 22 figures. Accepted to Astronomy and Astrophysic

Subarcsecond Submillimeter Imaging of the Ultracompact HII Region G5.89-0.39

We present the first subarcsecond submillimeter images of the enigmatic ultracompact HII region (UCHII) G5.89-0.39. Observed with the SMA, the 875 micron continuum emission exhibits a shell-like morphology similar to longer wavelengths. By using images with comparable angular resolution at five frequencies obtained from the VLA archive and CARMA, we have removed the free-free component from the 875 micron image. We find five sources of dust emission: two compact warm objects (SMA1 and SMA2) along the periphery of the shell, and three additional regions further out. There is no dust emission inside the shell, supporting the picture of a dust-free cavity surrounded by high density gas. At subarcsecond resolution, most of the molecular gas tracers encircle the UCHII region and appear to constrain its expansion. We also find G5.89-0.39 to be almost completely lacking in organic molecular line emission. The dust cores SMA1 and SMA2 exhibit compact spatial peaks in optically-thin gas tracers (e.g. 34SO2), while SMA1 also coincides with 11.9 micron emission. In CO(3-2), we find a high-velocity north/south bipolar outflow centered on SMA1, aligned with infrared H2 knots, and responsible for much of the maser activity. We conclude that SMA1 is an embedded intermediate mass protostar with an estimated luminosity of 3000 Lsun and a circumstellar mass of ~1 Msun. Finally, we have discovered an NH3 (3,3) maser 12 arcsec northwest of the UCHII region, coincident with a 44 GHz CH3OH maser, and possibly associated with the Br gamma outflow source identified by Puga et al. (2006).Comment: 41 pages, 11 figures, published in The Astrophysical Journal (2008) Volume 680, Issue 2, pp. 1271-1288. An error in the registration of the marker positions in Figure 11 has been corrected in this versio