Исследование алгоритмов функционирования СМО с использованием библиотеки SimEvents

Выпускная квалификационная работа 80 с., 18 рис., 6 табл., 21 источник. Объект исследования — модель управления графитовыми стержнями в ядерном реакторе. Цель работы — разработка модели управления замедляющими стержнями в реакторе с использованием библиотеки SimEvents. Изучены принципы имитационного моделирования с помощью библиотек SimEvents, Simulink. Разработана модель управления графитовыми стержнями в реакторе, получены параметры системы, проведен их анализ. Модель может использоваться как имитатор физического процесса в атомном производстве. Имитационная модель дает подтверждение расчетов, прогноз работы системы, позволяет исследовать работу в критических режимах. Планируется изучение новых характеристик системы, разработка более сложной модели, параметров, влияющих на новую модельGraduation qualification project consist of 80 p., 18 fig., 6 tab., 21 sources. The object of this study is graphite rods’s control model in nuclear reactors. The purpose of work – graphite rods’s control model development using SimEvents in nuclear reactors. Is studied the simulation principles using libraries SimEvents, Simulink. Are obtained the model of the control rods in the reactor graphite, the system parameters , their analysis was carried out. The model can be used as a simulator of a physical process in nuclear industry. A simulation model provides evidence calculations, the forecast of the system, allows you to explore the critical operation. It is planned to study the characteristics of the new system, the development of a more complex model, the parameters affecting a mode

Diagnostic and therapeutic yield of a patient-controlled portable EEG device with dry electrodes for home-monitoring neurological outpatients—rationale and protocol of the HOMEONE pilot study

Abstract Background The HOMEONE study is part of the larger HOME project, which aims to provide evidence of diagnostic and therapeutic yield (“change of management”) of a patient-controlled portable EEG device with dry electrodes for the purposes of EEG home-monitoring neurological outpatients. Methods The HOMEONE study is the first step in the process of investigating whether outpatient EEG home-monitoring changes the diagnosis and treatment of patients in comparison to conventional EEG (“change of management”). Both EEG devices (conventional and portable) will be systematically compared via a two-phase intra-individual assessment. In the first phase (pilot study phase), both EEG devices will be used within neurologist practices (all other things being equal). This pilot study (involving 130 patients) will evaluate the technical usability and efficacy of the new portable dry electrode EEG recorder in comparison to conventional EEG devices. Judgements will be based on technical assessments and EEG record examinations of private practitioners and two experienced neurologists (percent of concordant readings and kappa values). The second phase (feasibility study phase) aims to assess patients’ acceptability and feasibility of the EEG home-monitoring and will provide insights into the extent diagnostic and therapeutic yields can be expected. For this purpose, a conventional EEG will be recorded in neurologist practices. Thereafter, the practice staff will instruct the patients on how the portable EEG device functions. The patients will subsequently use the devices in their home environment. The evaluation will compare the before and after documented diagnostic findings and the therapeutic consequences of the private practitioners with those of two experienced neurologists. Discussion To the best of our knowledge, this will be the first study of its kind to examine new approaches to diagnosing unclear consciousness disorders or other disorders of the CNS or the cardiovascular system through the use of a patient-controlled portable EEG device with dry electrodes for the purpose of home-monitoring neurological outpatients. If the two phases of the HOMEONE study provide sufficient evidence of diagnostic and therapeutic yields, this would justify (indication-specific) full-scale randomized controlled trials or observational studies. Trial registration DRKS DRKS00012685. Registered 9 August 2017, retrospectively registered

Delivering bioactive compounds to fish larvae using microencapsulated diets

15 páginas, 6 figuras, 6 tablas.The efficient delivery of nutrients and hormones has special relevance to the development of rearing technologies for fish larvae and juveniles. The main aim is to find an effective and measurable way to administer them into the body of small aquatic animals. In this study, three different compounds (hormones, amino acids, and vitamins) were incorporated into protein-walled microencapsulated diets. Specifically these microencapsulated diets were examined for (a) the kinetics of incorporation of estradiol in Sparus aurata larvae, (b) absorption and leaching patterns of the free amino acids (FAA), and (c) growth results and tissue incorporation of vitamins in relation to the supplementation of vitamin C in larvae of S. aurata and Solea senegalensis. The efficiency of inclusion was relatively low, but the capsules were able to retain enough of these compounds when immersed in water and to deliver them into the digestive tract of the larvae. There are noticeable differences among the nominal amount of a given substance in the ingredient mixture, the actual amount in the microparticle and the amount delivered in the larval gut. It is therefore necessary to examine carefully whether the ingredient is reaching the digestive tract for achieving suitable conclusions in nutritional studies. These results indicate the applicability of these microencapsulated particles in nutritional studies of small aquatic animals.The Commission for Cultural, Educational and Scientific Exchange between the United States of America and Spain (project 97/156) and the Comisión Interministerial de Ciencia y Tecnología, Spain (CICYT Project AGL2000-0697-C02-01) supported this work.Peer reviewe

Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes

Introduction: In this study we sought to determine the cross-sectional area (CSA) of peripheral nerves in patients with distinct subtypes of amyotrophic lateral sclerosis (ALS). Methods: Ulnar and median nerve ultrasound was performed in 78 ALS patients [classic, n=21; upper motor neuron dominant (UMND), n=14; lower motor neuron dominant (LMND), n=20; bulbar, n=15; primary lateral sclerosis (PLS), n=8] and 18 matched healthy controls. Results: Compared with controls, ALS patients had significant, distally pronounced reductions of ulnar CSA (forearm/wrist level) across all disease groups, except for PLS. Median nerve CSA (forearm/wrist level) did not differ between controls and ALS. Conclusion: Ulnar nerve ultrasound in ALS subgroups revealed significant differences in distal CSA values, which suggests it has value as a marker of LMN involvement. Its potential was particularly evident in the UMND and PLS groups, which can be hard to separate clinically, yet their accurate separation has major prognostic implications