104 research outputs found
A model of ballistic aggregation and fragmentation
A simple model of ballistic aggregation and fragmentation is proposed. The
model is characterized by two energy thresholds, Eagg and Efrag, which
demarcate different types of impacts: If the kinetic energy of the relative
motion of a colliding pair is smaller than Eagg or larger than Efrag, particles
respectively merge or break; otherwise they rebound. We assume that particles
are formed from monomers which cannot split any further and that in a
collision-induced fragmentation the larger particle splits into two fragments.
We start from the Boltzmann equation for the mass-velocity distribution
function and derive Smoluchowski-like equations for concentrations of particles
of different mass. We analyze these equations analytically, solve them
numerically and perform Monte Carlo simulations. When aggregation and
fragmentation energy thresholds do not depend on the masses of the colliding
particles, the model becomes analytically tractable. In this case we show the
emergence of the two types of behavior: the regime of unlimited cluster growth
arises when fragmentation is (relatively) weak and the relaxation towards a
steady state occurs when fragmentation prevails. In a model with mass-dependent
Eagg and Efrag the evolution with a cross-over from one of the regimes to
another has been detected
Analytical Investigation of Innovation Dynamics Considering Stochasticity in the Evaluation of Fitness
We investigate a selection-mutation model for the dynamics of technological
innovation,a special case of reaction-diffusion equations. Although mutations
are assumed to increase the variety of technologies, not their average success
("fitness"), they are an essential prerequisite for innovation. Together with a
selection of above-average technologies due to imitation behavior, they are the
"driving force" for the continuous increase in fitness. We will give analytical
solutions for the probability distribution of technologies for special cases
and in the limit of large times.
The selection dynamics is modelled by a "proportional imitation" of better
technologies. However, the assessment of a technology's fitness may be
imperfect and, therefore, vary stochastically. We will derive conditions, under
which wrong assessment of fitness can accelerate the innovation dynamics, as it
has been found in some surprising numerical investigations.Comment: For related work see http://www.helbing.or
Statistical Mechanics of Canonical-Dissipative Systems and Applications to Swarm Dynamics
We develop the theory of canonical-dissipative systems, based on the
assumption that both the conservative and the dissipative elements of the
dynamics are determined by invariants of motion. In this case, known solutions
for conservative systems can be used for an extension of the dynamics, which
also includes elements such as the take-up/dissipation of energy. This way, a
rather complex dynamics can be mapped to an analytically tractable model, while
still covering important features of non-equilibrium systems. In our paper,
this approach is used to derive a rather general swarm model that considers (a)
the energetic conditions of swarming, i.e. for active motion, (b) interactions
between the particles based on global couplings. We derive analytical
expressions for the non-equilibrium velocity distribution and the mean squared
displacement of the swarm. Further, we investigate the influence of different
global couplings on the overall behavior of the swarm by means of
particle-based computer simulations and compare them with the analytical
estimations.Comment: 14 pages incl. 13 figures. v2: misprints in Eq. (40) corrected, ref.
updated. For related work see also:
http://summa.physik.hu-berlin.de/~frank/active.htm
Optimal Self-Organization
We present computational and analytical results indicating that systems of
driven entities with repulsive interactions tend to reach an optimal state
associated with minimal interaction and minimal dissipation. Using concepts
from non-equilibrium thermodynamics and game theoretical ideas, we generalize
this finding to an even wider class of self-organizing systems which have the
ability to reach a state of maximal overall ``success''. This principle is
expected to be relevant for driven systems in physics like sheared granular
media, but it is also applicable to biological, social, and economic systems,
for which only a limited number of quantitative principles are available yet.Comment: This is the detailled revised version of a preprint on
``Self-Organised Optimality'' (cond-mat/9903319). For related work see
http://www.theo2.physik.uni-stuttgart.de/helbing.html and
http://angel.elte.hu/~vicsek
Could Seals Prevent Cod Recovery in the Baltic Sea?
Fish populations are increasingly affected by multiple human and natural impacts including exploitation, eutrophication, habitat alteration and climate change. As a result many collapsed populations may have to recover in ecosystems whose structure and functioning differ from those in which they were formerly productive and supported sustainable fisheries. Here we investigate how a cod (Gadus morhua) population in the Baltic Sea whose biomass was reduced due to a combination of high exploitation and deteriorating environmental conditions might recover and develop in the 21st century in an ecosystem that likely will change due to both the already started recovery of a cod predator, the grey seal Halichoerus grypus, and projected climate impacts. Simulation modelling, assuming increased seal predation, fishing levels consistent with management plan targets and stable salinity, shows that the cod population could reach high levels well above the long-term average. Scenarios with similar seal and fishing levels but with 15% lower salinity suggest that the Baltic will still be able to support a cod population which can sustain a fishery, but biomass and yields will be lower. At present knowledge of cod and seal interactions, seal predation was found to have much lower impact on cod recovery, compared to the effects of exploitation and salinity. These results suggest that dual management objectives (recovery of both seal and cod populations) are realistic but success in achieving these goals will also depend on how climate change affects cod recruitment
Transitions in bacterial communities along the 2000 km salinity gradient of the Baltic Sea
Salinity is a major factor controlling the distribution of biota in aquatic systems, and most aquatic multicellular organisms are either adapted to life in saltwater or freshwater conditions. Consequently, the saltwater–freshwater mixing zones in coastal or estuarine areas are characterized by limited faunal and floral diversity. Although changes in diversity and decline in species richness in brackish waters is well documented in aquatic ecology, it is unknown to what extent this applies to bacterial communities. Here, we report a first detailed bacterial inventory from vertical profiles of 60 sampling stations distributed along the salinity gradient of the Baltic Sea, one of world's largest brackish water environments, generated using 454 pyrosequencing of partial (400 bp) 16S rRNA genes. Within the salinity gradient, bacterial community composition altered at broad and finer-scale phylogenetic levels. Analogous to faunal communities within brackish conditions, we identified a bacterial brackish water community comprising a diverse combination of freshwater and marine groups, along with populations unique to this environment. As water residence times in the Baltic Sea exceed 3 years, the observed bacterial community cannot be the result of mixing of fresh water and saltwater, but our study represents the first detailed description of an autochthonous brackish microbiome. In contrast to the decline in the diversity of multicellular organisms, reduced bacterial diversity at brackish conditions could not be established. It is possible that the rapid adaptation rate of bacteria has enabled a variety of lineages to fill what for higher organisms remains a challenging and relatively unoccupied ecological niche
Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
Candida albicans has been previously shown to stimulate the production of Pseudomonas aeruginosa phenazine toxins in dual-species colony biofilms. Here, we report that P. aeruginosa lasR mutants, which lack the master quorum sensing system regulator, regain the ability to produce quorum-sensing-regulated phenazines when cultured with C. albicans. Farnesol, a signalling molecule produced by C. albicans, was sufficient to stimulate phenazine production in LasR− laboratory strains and clinical isolates. P. aeruginosa ΔlasR mutants are defective in production of the Pseudomonas quinolone signal (PQS) due to their inability to properly induce pqsH, which encodes the enzyme necessary for the last step in PQS biosynthesis. We show that expression of pqsH in a ΔlasR strain was sufficient to restore PQS production, and that farnesol restored pqsH expression in ΔlasR mutants. The farnesol-mediated increase in pqsH required RhlR, a transcriptional regulator downstream of LasR, and farnesol led to higher levels of N-butyryl-homoserine lactone, the small molecule activator of RhlR. Farnesol promotes the production of reactive oxygen species (ROS) in a variety of species. Because the antioxidant N-acetylcysteine suppressed farnesol-induced RhlR activity in LasR− strains, and hydrogen peroxide was sufficient to restore PQS production in las mutants, we propose that ROS are responsible for the activation of downstream portions of this quorum sensing pathway. LasR mutants frequently arise in the lungs of patients chronically infected with P. aeruginosa. The finding that C. albicans, farnesol or ROS stimulate virulence factor production in lasR strains provides new insight into the virulence potential of these strains
The dynamic cilium in human diseases
Cilia are specialized organelles protruding from the cell surface of almost all mammalian cells. They consist of a basal body, composed of two centrioles, and a protruding body, named the axoneme. Although the basic structure of all cilia is the same, numerous differences emerge in different cell types, suggesting diverse functions. In recent years many studies have elucidated the function of 9+0 primary cilia. The primary cilium acts as an antenna for the cell, and several important pathways such as Hedgehog, Wnt and planar cell polarity (PCP) are transduced through it. Many studies on animal models have revealed that during embryogenesis the primary cilium has an essential role in defining the correct patterning of the body. Cilia are composed of hundreds of proteins and the impairment or dysfunction of one protein alone can cause complete loss of cilia or the formation of abnormal cilia. Mutations in ciliary proteins cause ciliopathies which can affect many organs at different levels of severity and are characterized by a wide spectrum of phenotypes. Ciliary proteins can be mutated in more than one ciliopathy, suggesting an interaction between proteins. To date, little is known about the role of primary cilia in adult life and it is tempting to speculate about their role in the maintenance of adult organs. The state of the art in primary cilia studies reveals a very intricate role. Analysis of cilia-related pathways and of the different clinical phenotypes of ciliopathies helps to shed light on the function of these sophisticated organelles. The aim of this review is to evaluate the recent advances in cilia function and the molecular mechanisms at the basis of their activity
Status of Biodiversity in the Baltic Sea
The brackish Baltic Sea hosts species of various origins and environmental tolerances. These immigrated to the sea 10,000 to 15,000 years ago or have been introduced to the area over the relatively recent history of the system. The Baltic Sea has only one known endemic species. While information on some abiotic parameters extends back as long as five centuries and first quantitative snapshot data on biota (on exploited fish populations) originate generally from the same time, international coordination of research began in the early twentieth century. Continuous, annual Baltic Sea-wide long-term datasets on several organism groups (plankton, benthos, fish) are generally available since the mid-1950s. Based on a variety of available data sources (published papers, reports, grey literature, unpublished data), the Baltic Sea, incl. Kattegat, hosts altogether at least 6,065 species, including at least 1,700 phytoplankton, 442 phytobenthos, at least 1,199 zooplankton, at least 569 meiozoobenthos, 1,476 macrozoobenthos, at least 380 vertebrate parasites, about 200 fish, 3 seal, and 83 bird species. In general, but not in all organism groups, high sub-regional total species richness is associated with elevated salinity. Although in comparison with fully marine areas the Baltic Sea supports fewer species, several facets of the system's diversity remain underexplored to this day, such as micro-organisms, foraminiferans, meiobenthos and parasites. In the future, climate change and its interactions with multiple anthropogenic forcings are likely to have major impacts on the Baltic biodiversity
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