Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging

Purpose To evaluate the diagnostic performance of imaging features of gadoxetic acid-enhanced magnetic resonance (MR) imaging to differentiate among hepatocellular adenoma (HCA) subtypes by using the histopathologic results of the new immunophenotype and genotype classification and to correlate the enhancement pattern on the hepatobiliary phase (HBP) with the degrees of expression of organic anion transporting polypeptide (OATP1B1/3), multidrug resistance-associated protein 2 (MRP) (MRP2), and MRP 3 (MRP3) transporters. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement for informed consent waived. MR imaging findings of 29 patients with 43 HCAs were assessed by two radiologists independently then compared with the histopathologic analysis as the standard of reference. Receiver operating characteristic curves and Spearman rank correlation coefficient were used to test the diagnostic performance of gadoxetic acid-enhanced MR imaging features, which included the retention or washout at HBP and degree of transporter expression. Interreader agreement was assessed by using the κ statistic with 95% confidence interval. Results The area under the curve for the diagnosis of inflammatory HCA was 0.79 (95% confidence interval: 0.64, 0.90); for the steatotic type, it was 0.90 (95% confidence interval: 0.77, 0.97); and for the β-catenin type, it was 0.87 (95% confidence interval: 0.74, 0.95). There were no imaging features that showed a significant statistical correlation for the diagnosis of unclassified HCAs. On immunohistochemical staining, OATP1B1/3 expression was the main determinant for the retention, whereas MRP3 was the key determinant for washout of gadoxetic acid at HBP (P < .001). MRP2 appeared to have no role. Conclusion Gadoxetic acid-enhanced MR imaging features may suggest the subtype of HCA. The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP. (©) RSNA, 2015 Online supplemental material is available for this article

Lithium and aluminium carbamato derivatives of the utility amide 2, 2, 6, 6- tetramethylpiperidide

Insertion of CO2 into the metal-N bond of a series of synthetically-important alkali-metal TMP (2,2,6,6-tetramethylpiperidide) complexes has been studied. Determined by X-ray crystallography, the molecular structure of the TMEDA-solvated Li derivative shows a central 8-membered (LiOCO)2 ring lying in a chair conformation with distorted tetrahedral lithium centres. While trying to obtain crystals of a THF solvated derivative, a mixed carbonato/carbamato dodecanuclear lithium cluster was formed containing two central (CO3)2- fragments and eight O2CTMP ligands with four distinct bonding modes. A bisalkylaluminium carbamato complex has also been prepared via two different methods (CO2 insertion into a pre-formed Al-N bond and ligand transfer from the corresponding lithium reagent) which adopts a dimeric structure in the solid state

Development of a novel flow sensor for copper trace analysis by electrochemical reduction of 4-methoxybenzene diazonium salt

Due to the rapidity and the effectiveness of the method, the reduction of diazonium salts has been widely used to functionalize electrodes for sensor applications. However, the resulting organic film usually designed to provide complexing capabilities for the species to be determined could affect the sensor properties. The electrochemical reduction of 4-methoxybenzene diazonium salt on graphite felt that leads to the formation of an organic film with unexpected high affinity for copper ions is presented. This property combined with a flow electrochemical system led us to achieve a sensitive sensor for copper detection, with good selectivity towards some common interferent ions. Keywords: Sensor, Graphite felt, Diazonium salts, Copper, Flo

The combined approach to query answering beyond the OWL 2 profiles.

Combined approaches have become a successful technique for CQ answering over ontologies. Existing algorithms, however, are restricted to the logics underpinning the OWL 2 profiles. Our goal is to make combined approaches applicable to a wider range of ontologies. We focus on RSA: a class of Horn ontologies that extends the profiles while ensuring tractability of standard reasoning. We show that CQ answering over RSA ontologies without role composition is feasible in NP. Our reasoning procedure generalises the combined approach for ELHO and DL-LiteR using an encoding of CQ answering into fact entailment w.r.t. a logic program with function symbols and stratified negation. Our results have significant practical implications since many out-of-profile Horn ontologies are RSA