83 research outputs found

    Development and Optimisation of a Robot Arm System for Additive Manufacturing Applications

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    The paper presents the development of a new platform that represents a robotic arm system, useful and appropriate for the Additive Manufacturing applications. The main objective of this work was to explore the feasibility of integrating the off-the-shelf (COTS) Additive Manufacturing technologies and the six-degree-of-freedom industrial robotic arm, achieving a 3D Additive Manufacturing system which is able to perform six-degree fused deposition printing. The authors investigated the materials suitable to be used and performed more experiments with the aim to find the right configuration of the printing system. Finally, the technical issues reported during the experimental programme have been solved, the system being prepared to carry out workpieces with more complex shapes and more types of polymers

    Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging

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    Purpose To evaluate the diagnostic performance of imaging features of gadoxetic acid-enhanced magnetic resonance (MR) imaging to differentiate among hepatocellular adenoma (HCA) subtypes by using the histopathologic results of the new immunophenotype and genotype classification and to correlate the enhancement pattern on the hepatobiliary phase (HBP) with the degrees of expression of organic anion transporting polypeptide (OATP1B1/3), multidrug resistance-associated protein 2 (MRP) (MRP2), and MRP 3 (MRP3) transporters. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement for informed consent waived. MR imaging findings of 29 patients with 43 HCAs were assessed by two radiologists independently then compared with the histopathologic analysis as the standard of reference. Receiver operating characteristic curves and Spearman rank correlation coefficient were used to test the diagnostic performance of gadoxetic acid-enhanced MR imaging features, which included the retention or washout at HBP and degree of transporter expression. Interreader agreement was assessed by using the κ statistic with 95% confidence interval. Results The area under the curve for the diagnosis of inflammatory HCA was 0.79 (95% confidence interval: 0.64, 0.90); for the steatotic type, it was 0.90 (95% confidence interval: 0.77, 0.97); and for the β-catenin type, it was 0.87 (95% confidence interval: 0.74, 0.95). There were no imaging features that showed a significant statistical correlation for the diagnosis of unclassified HCAs. On immunohistochemical staining, OATP1B1/3 expression was the main determinant for the retention, whereas MRP3 was the key determinant for washout of gadoxetic acid at HBP (P < .001). MRP2 appeared to have no role. Conclusion Gadoxetic acid-enhanced MR imaging features may suggest the subtype of HCA. The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP. (©) RSNA, 2015 Online supplemental material is available for this article

    Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

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    From conjunctive queries to SPARQL queries in ontology-mediated querying

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    We consider the rewritability of ontology-mediated queries (OMQs) based on UCQs into OMQs based on (certain kinds of) SPARQL queries. Our focus is on ALCI as a paradigmatic expressive DL. For rewritability into SPARQL queries that are unions of basic graph patterns, we show that the existence of a rewriting is decidable, based on a suitable characterization; for unary OMQs, this coincides with rewritability into instance queries. For SPARQL queries that additionally admit projection, we make some interesting first observations. In particular, we show that whenever there is a rewriting, then there is one that uses the same TBox as the original OMQ and only ALCI concepts from a certain finite class of such concepts. We also observe that if the TBox of the original OMQ falls into Horn-ALCI, then a rewriting always exists

    New modified porous electrodes for the removal of heavy metal ions from aqueous solutions

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