2,552 research outputs found
ALTERNATIVES AND CONSEQUENCES OF HEALTH CARE PROTOTYPES AND DEVELOPING A PUBLIC POLICY EDUCATION PROGRAM
Health Economics and Policy,
How isotropic is the Universe?
A fundamental assumption in the standard model of cosmology is that the
Universe is isotropic on large scales. Breaking this assumption leads to a set
of solutions to Einstein's field equations, known as Bianchi cosmologies, only
a subset of which have ever been tested against data. For the first time, we
consider all degrees of freedom in these solutions to conduct a general test of
isotropy using cosmic microwave background temperature and polarization data
from Planck. For the vector mode (associated with vorticity), we obtain a limit
on the anisotropic expansion of (95%
CI), which is an order of magnitude tighter than previous Planck results that
used CMB temperature only. We also place upper limits on other modes of
anisotropic expansion, with the weakest limit arising from the regular tensor
mode, (95% CI). Including all
degrees of freedom simultaneously for the first time, anisotropic expansion of
the Universe is strongly disfavoured, with odds of 121,000:1 against.Comment: 6 pages, 1 figure, v2: replaced with version accepted by PR
Sparse Inpainting and Isotropy
Sparse inpainting techniques are gaining in popularity as a tool for
cosmological data analysis, in particular for handling data which present
masked regions and missing observations. We investigate here the relationship
between sparse inpainting techniques using the spherical harmonic basis as a
dictionary and the isotropy properties of cosmological maps, as for instance
those arising from cosmic microwave background (CMB) experiments. In
particular, we investigate the possibility that inpainted maps may exhibit
anisotropies in the behaviour of higher-order angular polyspectra. We provide
analytic computations and simulations of inpainted maps for a Gaussian
isotropic model of CMB data, suggesting that the resulting angular trispectrum
may exhibit small but non-negligible deviations from isotropy.Comment: 18 pages, 6 figures. v3: matches version published in JCAP;
formatting changes and single typo correction only. Code available from
http://zuserver2.star.ucl.ac.uk/~smf/code.htm
A framework for testing isotropy with the cosmic microwave background
We present a new framework for testing the isotropy of the Universe using
cosmic microwave background data, building on the nested-sampling ANICOSMO
code. Uniquely, we are able to constrain the scalar, vector and tensor degrees
of freedom alike; previous studies only considered the vector mode (linked to
vorticity). We employ Bianchi type VII cosmologies to model the anisotropic
Universe, from which other types may be obtained by taking suitable limits. In
a separate development, we improve the statistical analysis by including the
effect of Bianchi power in the high-, as well as the low-,
likelihood. To understand the effect of all these changes, we apply our new
techniques to WMAP data. We find no evidence for anisotropy, constraining shear
in the vector mode to (95% CL). For the
first time, we place limits on the tensor mode; unlike other modes, the tensor
shear can grow from a near-isotropic early Universe. The limit on this type of
shear is (95% CL).Comment: 11 pages, 6 figures, v3: minor modifications to match version
accepted by MNRA
Functional Screening of the Cronobacter sakazakii BAA-894 Genome reveals a role for ProP (ESA_02131) in carnitine uptake
Cronobacter sakazakii is a neonatal pathogen responsible for up to 80% of fatalities in infected infants. Low birth weight infants and neonates infected with C. sakazakii suffer necrotizing enterocolitis, bacteraemia and meningitis. The mode of transmission most often associated with infection is powdered infant formula (PIF) which, with an aw of ∼0.2, is too low to allow most microorganisms to persist. Survival of C. sakazakii in environments subject to extreme hyperosmotic stress has previously been attributed to the uptake of compatible solutes including proline and betaine. Herein, we report the construction and screening of a C. sakazakii genome bank and the identification of ProP (ESA_02131) as a carnitine uptake system
Hierarchical Bayesian Detection Algorithm for Early-Universe Relics in the Cosmic Microwave Background
A number of theoretically well-motivated additions to the standard
cosmological model predict weak signatures in the form of spatially localized
sources embedded in the cosmic microwave background (CMB) fluctuations. We
present a hierarchical Bayesian statistical formalism and a complete data
analysis pipeline for testing such scenarios. We derive an accurate
approximation to the full posterior probability distribution over the
parameters defining any theory that predicts sources embedded in the CMB, and
perform an extensive set of tests in order to establish its validity. The
approximation is implemented using a modular algorithm, designed to avoid a
posteriori selection effects, which combines a candidate-detection stage with a
full Bayesian model-selection and parameter-estimation analysis. We apply this
pipeline to theories that predict cosmic textures and bubble collisions,
extending previous analyses by using: (1) adaptive-resolution techniques,
allowing us to probe features of arbitrary size, and (2) optimal filters, which
provide the best possible sensitivity for detecting candidate signatures. We
conclude that the WMAP 7-year data do not favor the addition of either cosmic
textures or bubble collisions to the standard cosmological model, and place
robust constraints on the predicted number of such sources. The expected
numbers of bubble collisions and cosmic textures on the CMB sky within our
detection thresholds are constrained to be fewer than 4.0 and 5.2 at 95%
confidence, respectively.Comment: 34 pages, 18 figures. v3: corrected very minor typos to match
published versio
Stock Market Indices: A Principal Components Analysis
This paper investigates a widely quoted stock market index, the Dow Jones Industrial Average (hereafter DJI), and constructs some alternative indices. Their performances are compared to the DJI. The question of applying the indices to problems of portfolio selection is explored when investors’ utility functions are quadratic in the rate of return. By constructing indices from data collected in different time periods, some conclusions are drawn about the constancy of price and rate of return covariance and correlation matrices of the 30 Dow Jones Industrial stocks over time
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