Modern treatment methods of primary childhood dental caries

The uniqueness of tooth enamel focal demineralization (primary caries) is that it is the only form of tooth decay, which can be treated conservatively without any surgical treatment and filling. Therefore, the integral task in dentistry is to study all the possibilities of diagnosis and to increase the effectiveness of conservative treatment. To determine the dental health of children in Omsk we carried out a dental check-up of 1682 schoolchildren from 7 to 12 years of ag

On the principles of the formation of anti-corruption world view of the personality of cadets of departmental educational institute

The article analyzes the principles of the formation of the anticorruption outlook of cadets of higher education institutions of the Ministry of Internal Affairs. Estimated importance of each of the principles and forms of its implementationВ статье анализируются принципы формирования антикоррупционного мировоззрения курсантов вузов МВД. Оценивается значимость каждого из принципов и формы его реализаци

Analysis of approaches to the formation of world outlook of students

The article analyzes the problem of the formation of the world outlook of students in higher educational institutions. The main approaches to the formation of the world outlook are considered. The importance of each of the approaches in the formation of the worldview is evaluatedВ статье анализируется проблема формирования мировоззрения обучающихся в высших учебных заведениях. Рассматриваются основные подходы к формированию мировоззрения. Оценивается значимость каждого из подходов в формировании мировоззрени

Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson's Disease

Intracellular quality control regulated by autophagy process is important for maintenance of cellular homeostasis. Deregulation of autophagy and more specifically mitophagy leads to accumulation of the misfolded proteins and damaged mitochondria that in turn leads to the cell loss. Alteration of autophagy and mitophagy has shown to be involved in the number of disorders including neurodegenerative diseases. Autophagy and mitophagy could be activated by short-time acidification of the cytosol; however, most of the compounds which can induce it are toxic. Here, we tested several organic compounds which are involved in cellular metabolism on their ability to change intracellular pH and induce mitophagy/autophagy. We have found that lactate and pyruvate are able to reduce intracellular pH in non-toxic concentrations. Short-term (2 h) and long-term (24 h) incubation of the cells with lactate and pyruvateinduced mitophagy and autophagy. Incubation of the SH-SY5Y cells or primary neurons and astrocytes with lactate or pyruvate also activated mitophagy and autophagy after MPP + treatment that led to recovery of mitochondrial function and protection of these cells against apoptotic and necrotic death. Thus, pyruvate- or lactate-induced acidification of cytosol activates cell protective mitophagy and autophagy

Semantic transformations of maritime historicisms in modern English

The article is dedicated to the study of English maritime historicisms in the modern English language. The author conducts research of English maritime historicisms aiming to prove that, firstly, they are actively used in modern English, secondly they changed their meanings and thirdly, their functions are not limited to the nominative one. Moreover, the author singles out numerous transformations that affect the meaning of maritime historicisms. The methods used by the author include: descriptive, comparative, systematizing methods and method of contextual analysis. The choice of maritime vocabulary as the material for analysis accounts for by two factors: 1) maritime affairs have always been closely associated with human activities of the British, hence, the English maritime vocabulary includes a large number of historicisms that were used to denote objects and events not existing now; 2) a considerable amount of written records where historicisms are used are still available, and on their basis maritime dictionaries which include historical terms have been compiled. The factual materials comprise numerous marine dictionaries, news columns, literary works, articles and encyclopedias. Conclusions reached by the author are as follows: English maritime historicisms form part of active vocabulary in the English language; four ways how they can change their meaning have been singled out and; apart from nominative function they perform expressive and evaluative functions as well. Theoretical and practical significance of the article consists not only in contributing to the knowledge about English maritime historicisms but also in tracing the association between Maritime History and its reflection in the English language. Moreover, the article can provide the basis for future research in discourse studies (e.g. studying the functional characteristics of historicisms in professional and non-professional communication) and terminological studies, translation of historicisms etc

Kinetics of Redox Reactions on Ti02 and NiO Single Crystals and Oxidized Metal Surfaces

Kinetics of Fe(CN) :· /Fe(CN) :- redox reaction couple on oxidized Ti, Ni and on Ti02 and NiO single crystals has been studied by fast methods of polarization and current measurements. From experimental values of the exchange-currents and transfer coefficients a and ~. and knowing the reaction mechanism, the potential distribution in the metal-oxide film - electrolyte system for Ti has been evaluated. It has been shown, that the main difference in properties of passive oxide films on Ni and Ti lies in the character of potential distribution at the oxide-solution interface

MODEL FORMING ANTI-CORRUPTION WORLDWIDE OF CADETS STUDYING AT THE UNIVERSITIES OF THE MINISTRY OF INTERNAL AFFAIRS

The article describes the ideas of building a model for the formation of an anti-corruption worldview among cadets studying at universities of the Ministry of Internal Affairs of the Republic of Kazakhstan, in the conditions of the educational processВ статье описываются идеи построения модели формирования антикоррупционного мировоззрения у курсантов, обучающихся в вузах МВД РК, в условиях образовательного процесса

Structure and Phase Composition of Zirconium Fuel Claddings in Initial State and after Creep Tests

The article's abstract is no available

Generation of recombinant adenoviral vectors encoding neural cell adhesion molecules ncam1, ncam2 and l1cam

To succed in gene therapy it is necessary to observe few basic conditions, such as targeted delivery of the therapeutic gene into the target organ and its effective expression. Nowadays targeted delivery of therapeutic genes is one of the critical problems of gene therapy. Delivery of recombinant genes using cell carriers (vectors), expressing tissue-specific cell adhesion molecules, allows us to move toward solving this problem. Using Gateway cloning technology (Invitrogen) we have created recombinant expression constructs pAd-NCAM1, pAd-NCAM2 and pAd-L1CAM, encoding neural cell adhesion molecules. Expression of recombinant proteins has been confirmed by immunofluorescent analysis. Based on these genetic constructs recombinant adenoviruses (serotype 5) were generated and titered. Obtained viral vectors encoding neural cell adhesion molecules may be subsequently used to modify cells carrying additional therapeutic genes to increase the efficiency of gene-cell therapeutics delivery to target organ. © Human stem cells institute, 2013