5 research outputs found
Vascular pathology of an eye and the threat of developing age-related macular degeneration after radiation exposure
On the contrary to the previous expectations, the most common Chornobyl catastrophe victim’s pathology was the vascular
pathology of an eye. The work is devoted to the assessment of changes in capillary tubes, arterioles and venules, which were irradiated
as a result of Chornobyl catastrophe and those who have been exposed to radiation while working in the Chornobyl exclusion zone.
The results of eye vascular system examination is presented by 615 persons: 358 Chornobyl clean-up workers, inspected in
1993–1994, 2007–2008 and 257 participants of works at the «Shelter» object, that were inspected in 2007–2008 and in 2017.
Microcirculatory damages in conjunctiva are the most early ionizing radiation induced eye damage. Dose dependence
from microcirculatory damages in conjunctiva has been proved. The conjunctiva index, which characterizes the evaluation degree
of microcirculatory abnormalities value for individuals irradiated at a dose of up to 10 mSv was 5.33±0.34, at a dose of 10 to
30 mSv – 9.71±0.93. Thus, a significant (t=4.42, p<0.05) increase in the display of microcirculatory abnormalities in conjunctiva
was revealed with an increase in the dose load. In the correlation analysis, there was found a direct connection, r=0.48, between the
conjunctiva index and the dose of irradiation.
The expressive tendency to correlate the negative dynamics of the macular zone with the degree of deterioration of microcirculation
shows the effect of microcirculatory disorders on the development of age-related macular degeneration. At the correlation
analysis, there was found a direct connection of significant decreased number of functioning capillaries with the deterioration of the
macular zone of the retina (r=0.37). It is also advisable to appoint prophylactic complexes of lutein and zeoxanthine to patients in the
case of microcirculatory disorders
Radiation-Induced Cerebro-Ophthalmic Effectsin Humans
: Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both
cognitive and visual impairments. The aim of this paper was to review and analyze the current
literature, and to comment on the ensuing findings in the light of our personal contributions in this
field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus,
Embase, PsycINFO and Google Scholar English papers published from January 2000 to January
2020. The results showed that prenatally or childhood-exposed individuals are a particular target
group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood
and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include
cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with
specific neurocognitive deficits. According to available information that eye alterations may induce
or may be associated with brain dysfunctions and vice versa, we propose to label this relationship
“eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable
markers of possible low dose IR-induced brain damage
Convergence and Divergence in Europe: Polish and Ukrainian Cases
The all-round aspects of bilateral relations are considered in the common Ukrainian-Polish monograph. Authors uncover important features of social-andeconomic systems convergence under conditions of globalization and European integration, as well as the further transformation of Central- and East European countries. The focus of the monograph is to analyze the characteristic features of the evolution of Polish and Ukrainian economic models.
The research interest of the authors of the monograph has been concentrated on the diversification of bilateral economic relations and subject to the fundamental objective – the co-integration of Ukraine and the EU, as well as the possibility of adapting the Polish experience of systemic transformation of the national social and economic model.
The monograph is addressed to scientists, politicians, public activists, diplomats, international experts, and to all those, who are not indifferent to the European prospect of Ukraine
Convergence and Divergence in Europe: Polish and Ukrainian Cases
The all-round aspects of bilateral relations are considered in the common Ukrainian-Polish monograph. Authors uncover important features of social-andeconomic systems convergence under conditions of globalization and European integration, as well as the further transformation of Central- and East European countries. The focus of the monograph is to analyze the characteristic features of the evolution of Polish and Ukrainian economic models.
The research interest of the authors of the monograph has been concentrated on the diversification of bilateral economic relations and subject to the fundamental objective – the co-integration of Ukraine and the EU, as well as the possibility of adapting the Polish experience of systemic transformation of the national social and economic model.
The monograph is addressed to scientists, politicians, public activists, diplomats, international experts, and to all those, who are not indifferent to the European prospect of Ukraine
VASCULAR PATHOLOGY OF AN EYE AND THE THREAT OF DEVELOPING AGE-RELATED MACULAR DEGENERATION AFTER RADIATION EXPOSURE
On the contrary to the previous expectations, the most common Chornobyl catastrophe victim’s pathology was the vascular pathology of an eye. The work is devoted to the assessment of changes in capillary tubes, arterioles and venules, which were irradiated as a result of Chornobyl catastrophe and those who have been exposed to radiation while working in the Chornobyl exclusion zone.The results of eye vascular system examination is presented by 615 persons: 358 Chornobyl clean-up workers, inspected in 1993–1994, 2007–2008 and 257 participants of works at the «Shelter» object, that were inspected in 2007–2008 and in 2017.Microcirculatory damages in conjunctiva are the most early ionizing radiation induced eye damage. Dose dependence from microcirculatory damages in conjunctiva has been proved. The conjunctiva index, which characterizes the evaluation degree of microcirculatory abnormalities value for individuals irradiated at a dose of up to 10 mSv was 5.33±0.34, at a dose of 10 to 30 mSv – 9.71±0.93. Thus, a significant (t=4.42, p<0.05) increase in the display of microcirculatory abnormalities in conjunctiva was revealed with an increase in the dose load. In the correlation analysis, there was found a direct connection, r = 0.48, between the conjunctiva index and the dose of irradiation.The expressive tendency to correlate the negative dynamics of the macular zone with the degree of deterioration of microcirculation shows the effect of microcirculatory disorders on the development of age-related macular degeneration. At the correlation analysis, there was found a direct connection of significant decreased number of functioning capillaries with the deterioration of the macular zone of the retina (r=0.37). It is also advisable to appoint prophylactic complexes of lutein and zeoxanthine to patients in the case of microcirculatory disorders