Methylprednisolone-induced toxic hepatitis after intravenous pulsed therapy for multiple sclerosis relapses

High-dose, intravenous methylprednisolone (MP) is the only recommended first-line treatment for multiple sclerosis relapses. However, there are increasing reports on liver toxicity induced by this treatment regimen. We report of 4 multiple sclerosis patients with no history of viral/metabolic liver disorders or alcohol/hepatotoxic drug intake, who developed hypertransaminasaemia following intravenous MP. In 2 of the patients, liver biopsy showed periportal fibrosis, piecemeal necrosis, and inflammatory cell infiltrates. A rechallenge test confirmed a causal association in 1 case. MP-induced liver toxicity may be more frequent than commonly thought and it is important to report this adverse reaction, which is potentially lethal, and to raise awareness on the potential hepatotoxicity of corticosteroid pulses

Dal passato al futuro: carte storiche, sicurezza idraulica, progettazione territoriale

Il poster propone metodologie di utilizzazione della cartografia storica nell'ambito della mitigazione del rischio idraulic

Il paesaggio dei tecnici. Attualità della cartografia storica per la gestione delle acque,

Il volume presenta studi interdisciplinari comparativi alla scala internazione che, dlala cartografia storica, portano ad applicativi GIS e alla partecipazione alla pianificazione territoriale e alla governo, conoscenza e mitigazione del rischio ambiental

Co-crystallization of paprika oleoresin and storage stability study

Paprika oleoresin was co-crystallized to formulate a natural and hydrophilic dye for use in food applications. The color stabilities of the co-crystallized and free oleoresins were evaluated at different temperatures (25 and 35 degrees C, 70% RH) and light exposures (light 70 watts and dark, 25 degrees C, 70% RH). Co-crystallization from supersaturated sucrose syrup (S = 1.32) was found to be optimum for the formation of sugar agglomerates in a few minutes, with the paprika oleoresin entrapped inside. With time, decreases in the values of the a(star) parameter and the beta-carotene content were observed with increasing temperature and with the incidence of light. The color degradation kinetics were dependent on both factors. The loss of color was greater for the free oleoresin as compared to the co-crystallized, suggesting that the co-crystallization process improves oleoresin retention in the sugar matrix, making it less susceptible to losses due to color degradation.39118218

Frequent early multiple sclerosis relapses during treatment with fingolimod: a paradoxical effect?

This is the case report of a multiple sclerosi patient who presented frequent relapses early after beginning a treatment with fingolimo

Recurrent varicella following steroids and fingolimod in a Multiple Sclerosis patient

This is the case report of a multiple sclerosis patient who presented recurrent varicella following steroid and fingolimod therap