Kennesaw State University Mixed Chamber Ensembles

The Mixed Chamber Ensembles present a concert featuring various string chamber pieces throughout the musical repertoire. There are two concerts: 5:30 PM and 8:00 PM. Presented virtually from Morgan Concert Hall of the Bailey Performance Center.https://digitalcommons.kennesaw.edu/musicprograms/2347/thumbnail.jp

Mixed Chamber Ensembles

Program for Mixed Chamber Ensembles performance on November 17, 2021.https://digitalcommons.kennesaw.edu/musicprograms/2462/thumbnail.jp

Faculty Recital: John Warren, clarinet

KSU School of Music presents John Warren, clarinet.https://digitalcommons.kennesaw.edu/musicprograms/1269/thumbnail.jp

Impact of Insulin Degludec/Liraglutide Fixed Combination on the Gut Microbiomes of Elderly Patients With Type 2 Diabetes: Results From A Subanalysis of A Small Non-Randomised Single Arm Study

In elderly Type 2 Diabetes (T2D) patients the relationship between the destabilization of gut microbiome and reversal of dysbiosis via glucose lowering drugs has not been explored. We investigated the effect of 6 months therapy with a fixed combination of Liraglutide and Degludec on the composition of the gut microbiome and its relationship with Quality of Life, glucose metabolism, depression, cognitive function, and markers of inflammation in a group of very old T2D subjects (n=24, 5 women, 19 men, mean age=82 years). While we observed no significant differences in microbiome biodiversity or community among study participants (N = 24, 19 men, mean age 82 years) who responded with decreased HbA1c (n=13) versus those who did not (n=11), our results revealed a significant increase in Gram-negative Alistipes among the former group (p=0.013). Among the responders, changes in the Alistipes content were associated directly with cognitive improvement (r=0.545, p=0.062) and inversely with TNF alpha levels (r=-0.608, p=0.036). Our results suggest that this combination drug may have a significant impact on both gastrointestinal microbes and cognitive function in elderly T2D individuals

Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue front NIDDM patients

Insulin/IGF-I hybrid receptors composed of an insulin receptor (IR) alpha beta-hemireceptor and a type 1 IGF receptor (IGF-IR) alpha beta-hemireceptor are formed in tissues expressing both molecules. To date there is a limited information about the proportion of hybrids in tissues of normal or diabetic subjects. In this study, we determined the abundance of hybrids in fat from control and NIDDM subjects by using a microwell-based immunoassay. Microwells coated with MA-20 anti-IR or alpha-IGF-IR-PA anti-IGF-IR antibody were incubated with tissue extracts. Immunoadsorbed receptors were incubated with I-125-insulin or I-125-IGF-I in the presence or absence of unlabeled ligands, and hybrids were quantitated as the fraction of I-125-IGF-I binding immunoadsorbed with MA-20. Abundance of hybrids was increased in NIDDM patients as compared with controls (B/T = 1.29 +/- 0.18 and 0.52 +/- 0.06%; P < 0.008, respectively), and it was inversely correlated with both IR number (r = -0.65; P < 0.002), and in vivo insulin sensitivity measured by insulin tolerance test (r = -0.75; P < 0.005), whereas it was positively correlated with insulinemia (r = 0.63: P < 0.003). Insulin binding affinity was lower in NIDDM subjects than in controls (ED50 = 1.87 +/- 0.32 and 0.54 +/- 0.20 nmol/l; P < 0.009, respectively), and was correlated with the percentage of hybrids. Maximal IGF-I binding was significantly greater in NIDDM patients than controls and was positively correlated with the percentage of hybrids whereas IGF-I binding affinity did not differ between the two groups. Results show that expression of hybrids is increased in fat of NIDDM patients compared to control subjects and is correlated with in vivo insulin sensitivity thus raising the possibility that alterations in expression of hybrids which bind IGF-I with higher affinity than insulin may contribute, at least in part, to insulin resistance. (C) 1997 Elsevier Science Ireland Ltd

Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. Am J Physiol Endocrinol Metab 2007;292:E347–E352

artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. Am J Physiol Endocrinol Metab 292: E347-E352, 2007. First published September 12, 2006; doi:10.1152/ajpendo.00291.2006.-The aim of this study was to investigate whether insulin resistance is independently associated with early manifestations of atherosclerosis. To this end, 176 normotensive offspring of type 2 diabetic patients were subjected to euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Early atherosclerosis was studied by ultrasonography of the common carotid artery. Of the total 176 subjects, 145 were glucose tolerant, 18 had impaired fasting glucose, and 13 had impaired glucose tolerance. Univariate correlations showed that age, body mass index, waist, blood pressure, 2-h postchallenge glucose, fasting insulin, triglycerides, interleukin-6, fibrinogen, and white blood cell count were significantly correlated with carotid intimamedia thickness (IMT), whereas HDL cholesterol and glucose disposal showed a negative correlation. A stepwise multivariate regression analysis including sex, age, waist circumference, smoking status, systolic blood pressure, diastolic blood pressure, triglyceride, HDL cholesterol, 2-h postchallenge glucose, plasma IL-6, fibrinogen, white blood cell count, insulin-stimulated glucose disposal, and fasting insulin showed that the four variables that remained significantly associated with carotid IMT were waist circumference, insulin-stimulated glucose disposal, white blood cell count, and diastolic blood pressure, accounting for 33.7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients. insulin sensitivity; atherosclerosis; plasma insulin levels; inflammation; white blood cell count THE METABOLIC SYNDROME is a constellation of interrelated risk factors that confer an increased risk to develop type 2 diabetes and atherosclerotic cardiovascular disease (37). According to the definition of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III), the metabolic syndrome is diagnosed when at least three of five risk factors are present, including an increased waist circumference, blood pressure (BP) elevation, low HDL cholesterol, high triglycerides, and hyperglycemia (30). Although there is still some debate about the nature of the metabolic syndrome (22), hyperinsulinemia and/or insulin resistance are thought to play a major pathogenetic role in clustering these risk factors. Many Accumulating evidence suggests that inflammation plays a role in the pathogenesis of insulin resistance, type 2 diabetes, and atherosclerosis Nondiabetic offspring of type 2 diabetic patients have become a valuable model for studying the pathogenic mechanism(s) responsible for the susceptibility of the metabolic syndrome, without the confounding effect of hyperglycemia. In fact, family history of type 2 diabetes is associated with both increased cardiovascular risk factors, including increased abdominal fat content, higher plasma levels of insulin, triglyceride and cholesterol, insulin resistance, elevated systolic BP (SBP), and lower HDL cholesterol, and increased risk of developing metabolic syndrom

Polymorphisms of the insulin receptor subtrate-2 in patients with type 2 diabetes

We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy). The allelic frequency of Gly1057Asp variant did not differ between diabetics (32.9%) and nondiabetic subjects, whatever their ethnicity was (35.8% and 33.7% from Lazio and Sicily, respectively). As compared with Gly/Gly subjects within each group, Asp/Asp individuals showed no differences in quantitative traits, including fasting insulin and C-peptide, and several indices of insulin sensitivity and secretion. Only one of the diabetic patients was heterozygous for the Leu647Val variant, and none of the control subjects carried this variant. This patient had three children who were also heterozygous for this variant. They were glucose tolerant, and their insulin sensitivity and insulin secretion indices were within the range of age-matched controls. We also analyzed IRS-2 function in fibroblasts from carriers of Gly1057Asp or Leu647Val variant. No defects in IRS-2 expression, insulin-stimulated phosphorylation, or binding to the p85 subunit of phosphatidylinositol 3-kinase were observed. These results strongly argue against a major role of IRS-2 polymorphisms in the pathogenesis of type 2 diabetes