Eyelid skin metastasis as first sign of breast cancer recurrence.

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An uncommon onychomadesis in adults

Onychomadesis can be attributed to a wide variety of causes, including allergic contact dermatitis, paronychia,pustular psoriasis, and trauma, and most cases are considered to be idiopathic. Onychomadesis at the same level involving several nails suggests a systemic cause, such as fever, erythroderma, use of drugs such as anti-tumoral chemotherapeutics, carbamazepine, lithium salts, retinoids and, at the infantile age, viral infections such as Kawasaki disease, and hand, foot, and mouth disease (HFMD). HFMD generally affects children younger than 10 years old and in adults has minor manifestations and thereby easily goes unrecognized

In-transit melanoma metastases

In-transit (IT) metastases refer to cutaneous or subcutaneous melanoma spread or recurrence, more than 2 cm away from the primary tumor but not beyond the draining regional lymph nodes. IT metastases treatment is challenging, owing to a wide range of clinical presentations, and the overall prognosis is quite poor (the 5-year survival ranges between 20 and 60%), since their appearance preludes systemic involvemen